Psychosocial risks in Metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Hanne Åström, Christine Takami Lageborn, Hannes Hagström

et al.

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly becoming more prevalent in the general population. MASLD common persons with low socioeconomic status (SES), yet little known about psychosocial challenges associated this disease, and clinical recommendations on how to approach are lacking.

Language: Английский

Influence of metabolic state and body composition on the action of pharmacological treatment of migraine DOI Creative Commons
Noor Bruijn,

Romy van Lohuizen,

Malgorzata Boron

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Feb. 12, 2024

Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in fertile years, and women. impacts quality life affected individuals tremendously and, addition, it associated highly prevalent metabolic diseases, such as obesity, diabetes mellitus thyroid dysfunction. Also, clinical response to drugs might be patients disease due body composition change. Therefore, efficacy antimigraine could altered both migraine disease. However, knowledge pharmacology related effects are limited. given relevance, this article provides comprehensive overview current research hypotheses influence state on action drugs. In functioning vice versa, diseases its hormonal modulating medication activity outlined. Future exploration personalizing treatment individual characteristics necessary enhance therapeutic strategies, especially increasing significance recent decades.

Language: Английский

Citations

11
Lab-on-chip technologies for exploring the gut–immune axis in metabolic disease DOI Creative Commons
Alexandra Wheeler, Verena Stoeger, Róisı́n M. Owens

et al.

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1266 - 1292

Published: Jan. 1, 2024

Further development of lab-on-chip platforms is required to create an environment capable hosting more complex microbiota and immune cells.

Language: Английский

Citations

10
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila DOI Creative Commons

Miaomiao Pan,

Chenhao Qian,

Shaoye Huo

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 9, 2025

The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized from tryptophan metabolism, has been identified as key mediator. However, it remains unclear whether specific microbial factors regulate metabolism to influence 5-HT production regulation. In this study, we analyzed 110 athletes undergoing closed training found that fecal lactate levels were significantly associated with indicators. We observed significant negative correlation between Akkermansia abundance athletes. Co-supplementation muciniphila (A. muciniphila) modulated by increasing enzyme TPH1 reducing IDO1, thus shifting kynurenine (Kyn) 5-HT. addition, enhanced the propionate capacity of A. muciniphila, potentially contributing reduction mice. Taken together, these findings suggest enteric collaboratively restore imbalance leading increased activity alleviating phenotypes. This study highlights intricate interplay metabolites regulation, offering potential avenues for microbiota-targeted therapeutic strategies anxiety.

Language: Английский

Citations

2
Persistent pollutant exposure impacts metabolomic profiles in polar bears and ringed seals from the High Arctic and Hudson Bay, Canada DOI
Anaïs Remili, Adam D. Morris, Derek C. G. Muir

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120862 - 120862

Published: Jan. 1, 2025

Language: Английский

Citations

1
Psychosocial risks in Metabolic dysfunction-associated steatotic liver disease DOI Creative Commons
Hanne Åström, Christine Takami Lageborn, Hannes Hagström

et al.

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 15, 2025

Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly becoming more prevalent in the general population. MASLD common persons with low socioeconomic status (SES), yet little known about psychosocial challenges associated this disease, and clinical recommendations on how to approach are lacking.

Language: Английский

Citations

1