
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: April 3, 2025
Life's Crucial 9 (LC9) is the latest indicator of cardiovascular health (CVH), and estimated glucose disposal rate (eGDR) a non-invasive insulin resistance (IR). However, relationships between LC9 eGDR congestive heart failure (CHF) remain unknown. In this cross-sectional study, participants aged ≥20 years in NHANES database from 2005 to 2018 were analyzed. Weighted linear regression, logistic subgroup analysis, restricted cubic spline (RCS) analysis employed analyze associations among LC9, eGDR, CHF. Mediation was used explore mediating role association A total 22,699 adult included, whom 661 suffered The mean age 47.52 (0.26) old, with 11186 (48.68%) males 11513 (51.32%) females. average value 71.16 (0.22), that 7.91 (0.04). After adjusting for confounding factors, regression showed independently positively associated (β: 1.11, 95%CI: 1.07 - 1.14, P < 0.0001). Logistic indicated both (OR: 0.76, 0.65 0.88, 0.001) 0.81, 0.76 0.86, 0.0001) negatively prevalence revealed CHF mainly mediated by proportion 66%. This study suggests higher scores values imply lower Meanwhile, main intermediate factor CHF, indicating good CVH may reduce improving IR.
Language: Английский