Recent discoveries of oral substances’ effects on osteoporosis treatment - novel markers and pathways DOI Creative Commons

Roksana Judek,

Emilia Latour, Marianna Latour

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 19, P. 54329 - 54329

Published: Aug. 30, 2024

The search for optimal osteoporosis treatments continues, as the medications currently used in clinical therapy carry a risk of rare but acute side effects. New knowledge about etiopathogenetic pathways and biomarkers enabled exact examination various oral substances, often previously recognised their positive impact on bone mass growth. A cross-section novel reports from this year applications many orally administered substances is presented. Diet, gut microbiota aspect, functional food, diabetes drug – empagliflozin variety known Chinese traditional medicine are now characterized context possible mechanism treating or preventing osteoporosis. progress density quality-regulating recognition led to finding multiple with favorable mediation properties. precise diagnosis substances' working mechanisms approves potential use new formulations treatments. Presently only diet supplementation, administrated antiosteoporotic core ingredients modernized medications, provided presumptive adverse effects ruled out.

Language: Английский

Multi-omics and Bioinformatics for the Investigation of Therapeutic Mechanism of Roucongrong Pill against Postmenopausal Osteoporosis DOI
Tao Jiang, Chenhao Li, Yufen Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118873 - 118873

Published: Oct. 1, 2024

Language: Английский

Citations

5
Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Jan. 3, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its troubling impact parathormone (PTH) Gut further complicates this. A model addressing seemingly contradictory reports regarding calcium, magnesium, efficacy among disparate groups presented. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) D3 Ca:Mg, facilitated by incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Jan. 10, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its troubling impact parathormone (PTH) Gut further complicates this. A model addressing seemingly contradictory reports regarding calcium, magnesium, efficacy among disparate groups presented. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) D3 Ca:Mg, facilitated by incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Jan. 21, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Feb. 2, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed.

Language: Английский

Citations

0
Vitamin D, Calcium to Magnesium Ratio, and the Gut Microbiome DOI Creative Commons
Patrick Chambers

Published: Feb. 11, 2025

The gut microbiome has been the subject of increasing interest as integral to our health. Few realize that enormous benefits vitamin D (VD) and magnesium (Mg) are highly dependent on a healthy microbiome. Short chain fatty acids, especially butyrate, reflect not only but also VD status. Suboptimal VD, Mg, or butyrate translates some degree dysbiosis vice versa. Mg secondary bile indoles, tryptophan, all microbial metabolites longevity agents, discussed. is indispensable synthesis active form 7-dehydrocholesterol (7-DHC) from acetate. 7-DHC substrate for solar conversion D3. steadily Ca:Mg in Western diet its ironic impact parathormone (PTH) Gut further complicates this. Biochemical physiologic interlinkages legion most remain hidden. This limited mini review exposes insight into tight linkage between 25(OH) Ca:Mg, facilitated by A model incorporating physiologically discordant reinforcing effects this based genes, culture, socioeconomic status, addresses seemingly contradictory reports regarding calcium (Ca), efficacy proposed. balance Ca at heart global epidemic insulin resistance. reliable method estimating intracellular Mg++ primary goal paper awaken public inadequacy RDA RDAs Ca. Using generally accepted serum reference ranges, difference RBC plasma basic physiology, one can both uncover serious shortfall involving three unequivocally demonstrate significant health risks linked an out range Ca:Mg. Conclusions observational experimental.

Language: Английский

Citations

0
Cross-talks between osteoporosis and gut microbiome DOI
Shiva Shankar Jha, Naveen Jeyaraman,

Madhan Jeyaraman

et al.

World Journal of Orthopedics, Journal Year: 2025, Volume and Issue: 16(3)

Published: March 12, 2025

Language: Английский

Citations

0
Recent discoveries of oral substances’ effects on osteoporosis treatment - novel markers and pathways DOI Creative Commons

Roksana Judek,

Emilia Latour, Marianna Latour

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 19, P. 54329 - 54329

Published: Aug. 30, 2024

The search for optimal osteoporosis treatments continues, as the medications currently used in clinical therapy carry a risk of rare but acute side effects. New knowledge about etiopathogenetic pathways and biomarkers enabled exact examination various oral substances, often previously recognised their positive impact on bone mass growth. A cross-section novel reports from this year applications many orally administered substances is presented. Diet, gut microbiota aspect, functional food, diabetes drug – empagliflozin variety known Chinese traditional medicine are now characterized context possible mechanism treating or preventing osteoporosis. progress density quality-regulating recognition led to finding multiple with favorable mediation properties. precise diagnosis substances' working mechanisms approves potential use new formulations treatments. Presently only diet supplementation, administrated antiosteoporotic core ingredients modernized medications, provided presumptive adverse effects ruled out.

Language: Английский

Citations

0