Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents DOI Creative Commons
Kara M. Duraccio,

Sarah Kamhout,

Isabella D. Wright

et al.

Frontiers in Sleep, Journal Year: 2023, Volume and Issue: 2

Published: Nov. 28, 2023

Introduction Aspects of circadian sleep health including alignment, phase, or chronotype may be related to mental outcomes in adolescents. Using novel and robust data collection methods, this study explored the relationship between adolescents' traits depression, anxiety, stress, emotional regulation. Methods Fifty-two healthy 14–18-year-olds (58% female; 94% European American) participated study. Across a 10-day period, participants completed wrist-worn actigraphy. Next, dim-light melatonin onset (DLMO) protocol where 12 saliva samples were collected over 6-h period measure phase. Circadian phase was calculated as duration time DMLO average across monitoring period. Social jetlag measured discrepancy times from weekday weekend. Participants Depression Anxiety Stress Scales (DASS-21), Emotion Regulation Questionnaire (ERQ), Morningness-Eveningness for Adolescents (MEQ). Following dichotomizing into clinically relevant groups (late vs. early aligned misaligned rhythms, minimal social presence jetlag, intermediate morningness eveningness chronotype), we conducted general linear models determine group differences (depression, expressive suppression, cognitive reappraisal) while controlling gender pubertal development. Results had large effect on depression symptoms adolescents, with adolescents later DLMO having significantly higher scores than those earlier ( p = 0.031). Chronotype medium but non-significant anxiety stress eveningness-tendencies morningness-tendencies 's 0.140 0.111, respectively). Conclusions In first ever using gold-standard methodologies examine observed that increased depressive compared Furthermore, who endorsed behaviors suggest tendencies have heightened stress/anxiety. These conclusions encourage future experimental research regarding topic help inform interventions aimed decrease

Language: Английский

Circadian immunity from bench to bedside: a practical guide DOI Creative Commons

Huram Mok,

Elaine Ostendorf,

Alex Ganninger

et al.

Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 134(3)

Published: Feb. 1, 2024

The immune system is built to counteract unpredictable threats, yet it relies on predictable cycles of activity function properly. Daily rhythms in are an expanding area study, and many originate from a genetically based timekeeping mechanism known as the circadian clock. challenge how harness these biological improve medical interventions. Here, we review recent literature documenting clocks organize fundamental innate adaptive activities, immunologic consequences rhythm sleep disruption, persisting knowledge gaps field. We then consider evidence linking vaccination, important clinical realization function. Finally, discuss practical steps translate immunity patient's bedside.

Language: Английский

Citations

7
Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents DOI Creative Commons
Kara M. Duraccio,

Sarah Kamhout,

Isabella D. Wright

et al.

Frontiers in Sleep, Journal Year: 2023, Volume and Issue: 2

Published: Nov. 28, 2023

Introduction Aspects of circadian sleep health including alignment, phase, or chronotype may be related to mental outcomes in adolescents. Using novel and robust data collection methods, this study explored the relationship between adolescents' traits depression, anxiety, stress, emotional regulation. Methods Fifty-two healthy 14–18-year-olds (58% female; 94% European American) participated study. Across a 10-day period, participants completed wrist-worn actigraphy. Next, dim-light melatonin onset (DLMO) protocol where 12 saliva samples were collected over 6-h period measure phase. Circadian phase was calculated as duration time DMLO average across monitoring period. Social jetlag measured discrepancy times from weekday weekend. Participants Depression Anxiety Stress Scales (DASS-21), Emotion Regulation Questionnaire (ERQ), Morningness-Eveningness for Adolescents (MEQ). Following dichotomizing into clinically relevant groups (late vs. early aligned misaligned rhythms, minimal social presence jetlag, intermediate morningness eveningness chronotype), we conducted general linear models determine group differences (depression, expressive suppression, cognitive reappraisal) while controlling gender pubertal development. Results had large effect on depression symptoms adolescents, with adolescents later DLMO having significantly higher scores than those earlier ( p = 0.031). Chronotype medium but non-significant anxiety stress eveningness-tendencies morningness-tendencies 's 0.140 0.111, respectively). Conclusions In first ever using gold-standard methodologies examine observed that increased depressive compared Furthermore, who endorsed behaviors suggest tendencies have heightened stress/anxiety. These conclusions encourage future experimental research regarding topic help inform interventions aimed decrease

Language: Английский

Citations

1