Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue DOI Creative Commons
Bernardo Aguzzoli Heberle, Kevin Fox, Lucas Lobraico Libermann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Objective To systematically review and meta-analyze bulk RNA sequencing studies comparing Alzheimer’s disease (AD) patients with controls in human brain tissue, assessing study quality identifying key genes pathways. Methods We searched PubMed, Web of Science, Scopus on September 23, 2023, for using RNAseq primary tissue from AD controls. Excluded were non-primary re-analyses without new data, limited types gene panels. Quality was assessed a 10-category tool. Meta-analysis used high-quality datasets. Results From 3,266 records, 24 met criteria. found 571 differentially expressed (DEGs) temporal lobe 189 frontal lobe; overlapping pathways included "Tube morphogenesis" "Neuroactive ligand-receptor interaction." Limitations Study heterogeneity data tables constrained the review. Conclusions Rigorous methods are vital transcriptomic studies. Findings enhance understanding changes, aiding biomarker therapeutic development. Registration PROSPERO (CRD42023466522).

Language: Английский

Perioperative Biomarkers: Updates, Utility, and Future Directions DOI
Emmanuelle Duceppe, George Tewfik,

Angela F. Edwards

et al.

International Anesthesiology Clinics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

0
Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models DOI Creative Commons
Edna Grünblatt, Cristine Marie Yde Ohki,

G Angelika Schmitt-Böhrer

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

Citations

0
Diagnostic performance of S100B assay for intracranial hemorrhage detection in patients with mild traumatic brain injury under antiplatelet or anticoagulant therapy DOI Creative Commons

Paul-André Poislane,

Mathilde Papin,

Damien Masson

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 17, 2025

The sampling of S100B protein has been proposed as a screening tool to identify patients with low risk post-traumatic intracranial hemorrhage. Its performance for on antiplatelet agents or anticoagulants is still debatable. This exploratory study evaluates the diagnostic accuracy concentrations, measured within 3 h head trauma, rule out hemorrhage in adults anticoagulant therapy. prospective enrolled adult presenting trauma last and under antiplatelets anticoagulants. We hypothesized that concentration 0,100 µg.L-1 negative predictive value over 0,99. Sensitivity, specificity, positive were analyzed. From June 2020 January 2023, 155 included. 119 had level at over. 8 an sensitivity was 1 (95%CI 0,68-1), specificity 0,25 0,18 - 0,32), 0,07 0.03-0.13), 0,90 1). suggests when performed 3-hour period after mild measurement accurate treated

Language: Английский

Citations

0
Author Response: Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis DOI
Sarah Holper, Paula Loveland, Leonid Churilov

et al.

Neurology, Journal Year: 2025, Volume and Issue: 104(6)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Editors' Note: Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis DOI
James E. Siegler, Steven Galetta

Neurology, Journal Year: 2025, Volume and Issue: 104(6)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Reader Response: Blood Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-Analysis DOI
Xinyi Jiao, Xudong Liu, Guoqing Tian

et al.

Neurology, Journal Year: 2025, Volume and Issue: 104(6)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Short sleep and obesity in midlife and the risk of cognitive decline and incident dementia in later life: the Whitehall II cohort study DOI Creative Commons
Hee Kyung Park, Philipp Frank, Longbing Ren

et al.

Wellcome Open Research, Journal Year: 2025, Volume and Issue: 10, P. 91 - 91

Published: Feb. 21, 2025

Obesity and short sleep duration have both been associated with an increased risk of dementia, but their combined impact the underlying mechanisms are not yet fully understood. Our aim is to investigate separate associations obesity cognitive decline dementia risk, whether these mediated by neuroinflammatory responses metabolic disturbances, as indicated blood-based biomarkers. This a prospective cohort study adults who were free had data on BMI at baseline in 1997-1999, tracked for diagnoses until 2023 via linkage electronic health records. Participants will be divided into four groups: (1) reference group (2) (≤6 hours) non-obese weight; (3) normal (≥30kg/m2); (4) obesity, main exposure group. Baseline biomarkers include glial fibrillary acidic protein (GFAP), chitinase-3-like (YKL-40), triggering receptor expressed myeloid cells 2 (TREM2), neurofilament-light chain (NfL), brain-derived neurotrophic factor (BDNF), measured from EDTA plasma, well insulin resistance fasting serum samples. Cognitive status, using tests executive function, memory, phonemic fluency semantic fluency, was assessed 2002-2004, 2007-2009, 2012-2013, 2015-2016. We use linear mixed-effects models Cox proportional hazard examine change functioning respectively. To partially mediate associations, formal mediation analyses performed, estimating proportion excess individually combination. The results this may shed light pathomechanisms terms neuroinflammation.

Language: Английский

Citations

0
Systematic review and meta‐analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue DOI Creative Commons
Bernardo Aguzzoli Heberle, Kevin Fox, Lucas Lobraico Libermann

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

We systematically reviewed and meta-analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients to controls in human brain tissue. searched PubMed, Web of Science, Scopus for RNAseq studies, excluding re-analyses limited small RNAs or gene panels. developed 10 criteria quality assessment performed a meta-analysis on three high-quality datasets. Of 3266 records, 24 qualified the systematic review, one study with datasets meta-analysis. The identified 571 differentially expressed genes (DEGs) temporal lobe 189 frontal lobe, including CLU GFAP. Pathway analysis suggested reactivation developmental processes adult AD brain. Limited data availability constrained These findings underscore need rigorous methods transcriptomic research better identify changes advance biomarker therapeutic development. This review is registered PROSPERO (CRD42023466522). Comprehensive review: Conducted first non-demented using primary Identified AD, revealing potential targets. discovery: Highlighted key overlapping pathways such as "tube morphogenesis" "neuroactive ligand-receptor interaction" that may play critical roles AD. Emphasized importance methodological rigor tools guide future Acknowledged access complete tables lack diversity existing datasets, which some analysis.

Language: Английский

Citations

0
Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue DOI Creative Commons
Bernardo Aguzzoli Heberle, Kevin Fox, Lucas Lobraico Libermann

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract Objective To systematically review and meta-analyze bulk RNA sequencing studies comparing Alzheimer’s disease (AD) patients with controls in human brain tissue, assessing study quality identifying key genes pathways. Methods We searched PubMed, Web of Science, Scopus on September 23, 2023, for using RNAseq primary tissue from AD controls. Excluded were non-primary re-analyses without new data, limited types gene panels. Quality was assessed a 10-category tool. Meta-analysis used high-quality datasets. Results From 3,266 records, 24 met criteria. found 571 differentially expressed (DEGs) temporal lobe 189 frontal lobe; overlapping pathways included "Tube morphogenesis" "Neuroactive ligand-receptor interaction." Limitations Study heterogeneity data tables constrained the review. Conclusions Rigorous methods are vital transcriptomic studies. Findings enhance understanding changes, aiding biomarker therapeutic development. Registration PROSPERO (CRD42023466522).

Language: Английский

Citations

0