Ouabain Ameliorates Alzheimer’s Disease-Associated Neuropathology and Cognitive Impairment in FAD4T Mice

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3558 - 3558

Published: Oct. 20, 2024

Alzheimer's disease (AD) is a common clinical neurodegenerative disorder, primarily characterized by progressive cognitive decline and behavioral abnormalities. The hallmark pathological changes of AD include widespread neuronal degeneration, plaques formed the deposition amyloid β-protein (Aβ), neurofibrillary tangles (NFTs). With acceleration global aging, incidence rising year year, making it major public health concern. Due to complex pathology AD, finding effective interventions has become key focus research. Ouabain (OUA), cardiac glycoside, well-known for its efficacy in treating heart disease. Recent studies have also indicated potential therapy, although exact mechanism action remains unclear.

Language: Английский

The impact of 3-sulfo-taurolithocholic acid on ATPase activity in patients’ colorectal cancer and normal colon tissues, and its hepatic effects in rodents

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 5, 2024

Colorectal cancer is influenced by genetic mutations, lifestyle factors, and diet, particularly high fat intake, which raises bile acid levels in the intestinal lumen. This study hypothesized that acids contribute to tumorigenesis disrupting ion transport ATPase activity mucosa. The effects of 3-sulfo-taurolithocholic (TLC-S) on were investigated colorectal samples from 10 patients, using adjacent healthy tissue as controls, rodent liver function. was measured spectrophotometrically determining inorganic phosphorus (P

Language: Английский