bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: March 16, 2025
Abstract During the regeneration of injured or lost tissues, blastema serves as a hub for robust growth. Drosophila imaginal discs are genetically tractable and simple model system study organization this regrowth. Key signals that contribute to regenerative growth in these discs, such ROS, Wnt/Wg, JNK, p38, JAK/STAT, Hippo pathway, have been identified. However, detailed exploration spatial regrowth, factors directly drive growth, consequences activating drivers has not undertaken. Here, we find is controlled by transcription factor Myc Tor signaling, which additively proliferation translation blastema. The arranged into concentric zones defined expression, elevated activity, translation. In addition, increased expression innermost zone induced Xrp1-independent cell competition-like death adjacent zones, revealing delicate balance between driving inducing regenerating tissue. Summary statement wing disc characterized factor, signaling Myc-induced competition .
Language: Английский