Stem cell-based models of early human development DOI
Lizhong Liu, Jun Wu

Development, Journal Year: 2025, Volume and Issue: 152(8)

Published: April 15, 2025

ABSTRACT Stem cell-based embryo models (SCBEMs) are structures generated from three-dimensional (3D) culture of pluripotent stem cells and their derivatives, utilizing mechanical and/or chemical cues to facilitate lineage differentiation, self-organization morphogenesis. These partially mimic early embryos, which would otherwise be difficult access. SCBEMs have been established in mice, livestock, nonhuman primates humans. Here, we focus on recently developed human models, with an emphasis the peri-implantation stage aspects development these recapitulate.

Language: Английский

Stem cell-based models of early human development DOI
Lizhong Liu, Jun Wu

Development, Journal Year: 2025, Volume and Issue: 152(8)

Published: April 15, 2025

ABSTRACT Stem cell-based embryo models (SCBEMs) are structures generated from three-dimensional (3D) culture of pluripotent stem cells and their derivatives, utilizing mechanical and/or chemical cues to facilitate lineage differentiation, self-organization morphogenesis. These partially mimic early embryos, which would otherwise be difficult access. SCBEMs have been established in mice, livestock, nonhuman primates humans. Here, we focus on recently developed human models, with an emphasis the peri-implantation stage aspects development these recapitulate.

Language: Английский

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