Food insecurity promotes adiposity in mice

Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract Objective The obesity epidemic, driven by a complex interplay of environmental and biological factors, remains significant global health challenge. Herein, we investigate the impact food insecurity, characterized unpredictable access, on regulation body weight composition in mice. Methods Male female C57BL/6J mice were subjected to combination intermittent fasting calorie restriction simulate insecurity. Results Our new model demonstrates that insecurity increases fat mass decreases lean both sexes standard chow diet. Additionally, high‐fat diet‐fed male exposed paradigm show decreased despite being positive energy balance. Transcriptomic analysis white adipose tissue from food‐insecure revealed upregulation metabolic pathways associated with expansion downregulation immune response‐related transcripts. Conclusions These findings underscore role driving adaptations favor storage. Understanding this paradoxical link between adiposity is crucial for developing targeted interventions address disproportionate incidence socioeconomically disadvantaged populations.

Language: Английский

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A Syndemic Perspective on Food Insecurity, Gestational Diabetes, and Mental Health Disorders during Pregnancy

Social Science & Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 117994 - 117994

Published: March 1, 2025

Language: Английский

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Cognitive Decline and Food Insecurity in Older Brazilian Adults Registered with Primary Health Care: A Cross-sectional Study

Salud Mental, Journal Year: 2025, Volume and Issue: 48(2), P. 91 - 98

Published: March 3, 2025

Introduction: Cognitive decline (CD) is the deterioration of intellectual abilities, damaging areas such as memory, language, and learning. An insufficient diet, common among those facing food insecurity (FI), can contribute to CD in older adults by affecting nutrient intake, maintenance nutritional health status. Objective: To determine association between FI enrolled Primary Health Care (PHC). Method: This a cross-sectional study people aged 60 or over living private households municipality Northeast Brazil, registered with Family Strategy (FHS). The dependent variable was assessed using Mini Mental State Examination (MMSE). evaluated Brazilian Food Insecurity Scale (EBIA). Descriptive analysis, Pearson’s chi-squared test, logistic regression were used analyze data. Results: Three hundred sixteen assessed, 63.3% whom faced 59.8% presented CD. Bivariate analysis revealed an (p-value = .026). results only showed statistically significant moderate/severe (OR 1.878; 95% CI: 1.002 - 3.521). There no mild 1.529; 0.888 2.634). Discussion conclusion: PHC patients. Restricted dietary habits regard both quantity quality may make this population more susceptible

Language: Английский

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Translational science approaches for food insecurity research

Appetite, Journal Year: 2024, Volume and Issue: 200, P. 107513 - 107513

Published: May 23, 2024

Language: Английский

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