Serum miR-122 levels correlate with diabetic retinopathy

Clinical and Experimental Medicine, Journal Year: 2019, Volume and Issue: 19(2), P. 255 - 260

Published: Jan. 23, 2019

Language: Английский

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Post-Myocardial Infarction Ventricular Remodeling Biomarkers—The Key Link between Pathophysiology and Clinic

Biomolecules, Journal Year: 2020, Volume and Issue: 10(11), P. 1587 - 1587

Published: Nov. 23, 2020

Studies in recent years have shown increased interest developing new methods of evaluation, but also limiting post infarction ventricular remodeling, hoping to improve function and the further evolution patient. This is point where biomarkers proven effective early detection remodeling phenomena. There are six main processes that promote each them has specific can be used predicting (myocardial necrosis, neurohormonal activation, inflammatory reaction, hypertrophy fibrosis, apoptosis, mixed processes). Some such as creatine kinase–myocardial band (CK-MB), troponin, N-terminal-pro type B natriuretic peptide (NT-proBNP) were so convincing they immediately found their place patient evaluation protocol. Others related more complex biomarkers, atheroma plaque destabilization microRNA still being studied, results far promising. article aims review markers far, existing data on could considered, taking into consideration most important studies been conducted far.

Language: Английский

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Circular RNAs as potential biomarkers and therapeutics for cardiovascular disease

PeerJ, Journal Year: 2019, Volume and Issue: 7, P. e6831 - e6831

Published: May 8, 2019

Circular RNAs (circRNAs) are genetic regulators that were earlier considered as "junk". In contrast to linear RNAs, they have covalently linked ends with no polyadenylated tails. CircRNAs can act RNA-binding proteins, sequestering agents, transcriptional regulators, well microRNA sponges. addition, it is reported some selected circRNAs transformed into functional proteins. These RNA molecules always circularize through covalent bonds, and their presence has been demonstrated across species. They usually abundant stable evolutionarily conserved in tissues (liver, lung, stomach), saliva, exosomes, blood. Therefore, proposed the "next big thing" molecular biomarkers for several diseases, particularly cancer. Recently, investigated cardiovascular diseases (CVD) play important roles heart failure, coronary artery disease, myocardial infarction. Here, we review recent literature discuss impact diagnostic prognostic values of CVD.

Language: Английский

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A systematic review of miRNAs as biomarkers for chemotherapy-induced cardiotoxicity in breast cancer patients reveals potentially clinically informative panels as well as key challenges in miRNA research

Cardio-Oncology, Journal Year: 2022, Volume and Issue: 8(1)

Published: Sept. 7, 2022

Abstract Breast cancer patients are at a particularly high risk of cardiotoxicity from chemotherapy having detrimental effect on quality-of-life parameters and increasing the mortality. Prognostic biomarkers would allow management therapies to mitigate risks in vulnerable key potential candidate for such microRNAs (miRNA). miRNAs post-transcriptional regulators gene expression which can also be released into circulatory system have been associated with progression many chronic diseases including types cancer. In this review, evidence application as chemotherapy-induced (CIC) breast patientsis evaluated simple meta-analysis is performed confirm replication status each reported miRNA. Further selection by reviewing associations miRNA other cardiovascular conditions. Based research, most representative panels targeting specific agents treatment regimens suggested, that contain several informative miRNAs, both general markers cardiac damage well those treatments.

Language: Английский

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MiRroring the Multiple Potentials of MicroRNAs in Acute Myocardial Infarction

Frontiers in Cardiovascular Medicine, Journal Year: 2017, Volume and Issue: 4

Published: Nov. 19, 2017

At present, cardiovascular diseases are depicted to be the leading cause of death worldwide according World Health Organization. In future, projections predict that ischemic heart disease will persist in top main causes illness. Within this alarming context, some tiny master regulators gene expression programs, namely microRNAs carry three promising potentials. fact, miRNAs can prove useful terms biomarkers allowing injury detection, but also therapeutics overcome limitations past strategies and treat lesions. a more creative approach, they even used area human engineered cardiac tissues as maturation tools for cardiomyocytes derived from pluripotent stem cell. Very not only patient-specific cell-based therapies develop biomimetic microsystems modelling drug screening, these cells greatly contribute personalized medicine. To get into matter, focus review lies primarily on acute myocardial infarction biomarkers. Only large cohort studies comprising over one hundred individuals reach potent statistical value were considered. Certain appeared possibly complement protein-based classical risk factors. Some described bear potential discrimination similar symptomatic pathologies. However, differences between pre-analytical analytical approaches substantially influenced miRNA data. Further supported by meta-analysis studies, problematic had addressed. A detailed critical analysis each step define biomarker is provided inspire future improved universal strategy. Interestingly, recurrent set cardiomyocyte-enriched was found, miR-1; miR-133; miR-208a/b miR-499a. Each member myomiRs group displayed roles either individually or combination diagnostic prognostic Furthermore, precise combo shown powerful enough transdifferentiate fibroblasts opening doors therapeutics. Following discoveries, emerged optional transfect order mature cells. Ultimately, multiple potentials carried miR-499a still remain fully unveiled.

Language: Английский

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