Impact of an Intensive Lipid-Lowering Therapy Protocol on Achieving Target Low-Density Lipoprotein Cholesterol Levels in Patients With Acute Coronary Syndrome

Circulation Reports, Journal Year: 2025, Volume and Issue: 7(2), P. 131 - 138

Published: Jan. 10, 2025

Background: Intensive lipid-lowering therapy (ILLT) is crucial for preventing secondary acute coronary syndrome (ACS). However, achieving target low-density lipoprotein cholesterol (LDL-C) levels remains challenging in clinical practice.

Language: Английский

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Characteristics of Patients With Acute Coronary Syndrome and Lipid Management Status Insights From the Optimal Therapy for All Kagoshima Acute Coronary Syndrome (OK-ACS) Registry

Circulation Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

With aging of the population, atherosclerotic diseases have increased in Japan, with acute coronary syndrome (ACS) a significant cause morbidity and mortality. In Kagoshima Prefecture, ACS mortality rates exceed national average, reflecting challenges lipid management access to care. The Optimal Therapy for All Acute Coronary Syndrome (OK-ACS) Registry, initiated April 2022, enrolled 2,328 patients across Kagoshima. This study evaluated impact standardized pathway, "Kagoshima Style," on low-density lipoprotein cholesterol (LDL-C) control guideline adherence, as well regional profile pathway was implemented at all percutaneous intervention facilities optimize secondary prevention. LDL-C levels decreased significantly (P<0.0001) from admission discharge 3 months (113.3±39.9, 74.6±28.0, 69.2±25.9 mg/dL, respectively), no difference according place residence. proportion <70 mg/dL 12% 59% months. Maximum tolerated doses high-intensity statin use 7% baseline 9.3% after implementation. Geographic disparities were evident, isolated islands experiencing delayed treatment access. Style improved management, reducing enhancing adherence. interim analysis provides insights into prefecture.

Language: Английский

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Pericoronary adipose tissue: potential for pathological diagnosis and therapeutic applications

Cardiovascular Intervention and Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 5, 2025

Language: Английский

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Do You Prescribe PCSK9 Inhibitors Properly?

Circulation Journal, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Language: Английский

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