The relationship between Ribosome-associated Quality Control and neurological disorders DOI
Juan Wang, Jianhua Wang,

Hanshuai Cao

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 80(4)

Published: Dec. 25, 2024

Abstract Ribosome-associated quality control (RQC), a ubiquitous process essential for maintaining protein homeostasis in eukaryotes, acts as critical surveillance system translation. By identifying and eliminating stalled ribosomes, RQC prevents aberrant translation the production of potentially toxic misfolded proteins. The review focuses on role mammals, where its complete functionality remains to be elucidated. This study delves into mechanisms through which dysfunction plays development neurological disorders, focusing neurodegenerative neurodevelopmental diseases. We explore underlying by contributes pathogenesis particularly Further research is crucial unravel intricate governing RQC’s influence function. knowledge will pave way exploring therapeutic avenues targeting factors potential interventions these debilitating shedding light contribution this opens doors developing targeted therapies interventions.

Language: Английский

Cytoplasmic mRNA decay and quality control machineries in eukaryotes DOI
Megan E. Dowdle, Jens Lykke‐Andersen

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

Citations

1
Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress DOI Creative Commons
Austin Maduka, Sandhya Manohar, Matthew W. Foster

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

ABSTRACT Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate supporting defenses at several subcellular compartments. However, the rules driving ubiquitin localization these concerted response mechanisms remain understudied. Here, we show that K63-linked chains, known proteasome-independent pathways, accumulate primarily in non-cytosolic compartments induced by sodium arsenite mammalian cells. Our proteomic analyses of expanded 10-fold pool proteins be ubiquitinated (2,046) revealed involvement pathways related immune translation control. Moreover, proteome are recruited under including a significant enrichment helper ubiquitin-binding adaptors ATPase VCP processes substrates for downstream signaling. We further recruitment occurs ubiquitin-dependent manner mediated its adaptor NPLOC4. Additionally, NPLOC4 activities critical sustain low levels cyclical model conjugation removal disrupted cellular exposure reactive oxygen species. This work deepens our understanding role localized basic highlights new players essential reshape composition function human dynamic environments.

Language: Английский

Citations

0
The relationship between Ribosome-associated Quality Control and neurological disorders DOI
Juan Wang, Jianhua Wang,

Hanshuai Cao

et al.

The Journals of Gerontology Series A, Journal Year: 2024, Volume and Issue: 80(4)

Published: Dec. 25, 2024

Abstract Ribosome-associated quality control (RQC), a ubiquitous process essential for maintaining protein homeostasis in eukaryotes, acts as critical surveillance system translation. By identifying and eliminating stalled ribosomes, RQC prevents aberrant translation the production of potentially toxic misfolded proteins. The review focuses on role mammals, where its complete functionality remains to be elucidated. This study delves into mechanisms through which dysfunction plays development neurological disorders, focusing neurodegenerative neurodevelopmental diseases. We explore underlying by contributes pathogenesis particularly Further research is crucial unravel intricate governing RQC’s influence function. knowledge will pave way exploring therapeutic avenues targeting factors potential interventions these debilitating shedding light contribution this opens doors developing targeted therapies interventions.

Language: Английский

Citations

0