The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007–2016 DOI Creative Commons
Huichun Xu, Yiming Ding, Ye Zhang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Objective Serum klotho protein is a with anti-aging effects. Since the relationship between serum and Stroke remains rather ambiguous, this research probed into potential correlation concentration Stroke. Methods This study employed cross-sectional design incorporated population data from NHANES 2007 to 2016. Weighted univariate multivariate logistic regression models were utilized inspect Stratified analyses interaction tests carried out explore latent Finally, fitted smooth curve was adopted depict non-linear relationship. Results In study, after excluding all missing data, total of 12,414 participants encompassed, including 450 individuals. After adjusting for covariates, higher associated lower prevalence According subgroup tests, age, gender, race, BMI, hypertension, diabetes mellitus, family members, drinker smoker not significantly correlated influence stroke [OR: 0.68, 95% CI: 0.47–0.99]. Conclusion disclosed negative levels Further prospective studies are requisite investigate impact on determine causal

Language: Английский

Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults DOI Creative Commons
Xinliang Zheng,

Wenxin Zhou,

Zhuoying Jiang

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 237 - 237

Published: March 24, 2025

α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on levels remains unclear. This study investigated the relationship between urinary concentrations serum using data from National Health Nutrition Examination Survey (NHANES) 2007–2016 cycles. A total of 4071 adults aged 40 79 years were included in analysis. After adjusting for potential confounders, positive associations found barium (Ba), cesium (Cs), molybdenum (Mo), while tungsten (W) uranium (U) negatively correlated levels. The combined effects multiple metals further analyzed qgcomp model, which demonstrated a negative correlation increased mixtures Specifically, U, arsenic (t-As), W, cadmium (Cd), antimony (Sb), lead (Pb) contributed reduction levels, Ba, Cs, dimethylarsinic acid (DMA), Mo, thallium (Tl), cobalt (Co) positively These findings suggest that certain metals, particularly combination, may reduce potentially accelerating aging processes. Further studies should investigate underlying mechanisms responsible these associations.

Language: Английский

Citations

0
The association between serum klotho protein and stroke: a cross-sectional study from NHANES 2007–2016 DOI Creative Commons
Huichun Xu, Yiming Ding, Ye Zhang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Objective Serum klotho protein is a with anti-aging effects. Since the relationship between serum and Stroke remains rather ambiguous, this research probed into potential correlation concentration Stroke. Methods This study employed cross-sectional design incorporated population data from NHANES 2007 to 2016. Weighted univariate multivariate logistic regression models were utilized inspect Stratified analyses interaction tests carried out explore latent Finally, fitted smooth curve was adopted depict non-linear relationship. Results In study, after excluding all missing data, total of 12,414 participants encompassed, including 450 individuals. After adjusting for covariates, higher associated lower prevalence According subgroup tests, age, gender, race, BMI, hypertension, diabetes mellitus, family members, drinker smoker not significantly correlated influence stroke [OR: 0.68, 95% CI: 0.47–0.99]. Conclusion disclosed negative levels Further prospective studies are requisite investigate impact on determine causal

Language: Английский

Citations

0