Disease Markers,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 10
Published: June 24, 2022
The
eye
is
one
of
the
most
important
organs
human
body.
Eye
diseases
are
closely
related
to
other
systemic
diseases,
both
which
influence
each
other.
Numerous
lead
special
clinical
manifestations
and
complications
in
eyes.
Typical
include
diabetic
retinopathy,
hypertensive
thyroid
associated
ophthalmopathy,
optic
neuromyelitis,
Behcet’s
disease.
Systemic
disease-related
ophthalmopathy
usually
a
chronic
disease,
analysis
imaging
markers
helpful
for
comprehensive
diagnosis
these
diseases.
Recently,
artificial
intelligence
(AI)
technology
based
on
deep
learning
has
rapidly
developed,
leading
numerous
achievements
arousing
widespread
concern.
Presently,
AI
made
significant
progress
research
ophthalmopathy;
however,
there
also
many
limitations
challenges.
This
article
reviews
achievements,
limitations,
future
prospects
image
ophthalmopathy.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 21, 2025
Background
Zhilong
Huoxue
Tongyu
Capsule
(ZLHXTY)
has
been
used
in
clinical
treatment
of
vascular
diseases
caused
by
hypertension
over
20
years.
However,
the
specific
mechanisms
ZLHXTY
alleviate
hypertensive
retinopathy
(HR)
needs
to
be
further
explored.
Materials
and
methods
HR
mouse
model
was
established
infusing
Ang
II
via
subcutaneously
implanted
osmotic
mini-pumps,
followed
oral
administration
(0.35,
0.7,
1.4
g/kg/day)
28
days
for
treatment.
To
assess
impacts
on
retinal
neurodegeneration
injury,
multiple
experiments
such
as
OCTA,
ERG
HE
staining
were
performed.
Subsequently,
network
pharmacological
4D-label-free
proteomics
clarify
potential
targets
alleviated
HR.
Finally,
Western
blot,
ELISA,
IF,
other
techniques
utilized
detect
expression
proteins
related
inflammation,
oxidative
stress,
NLRP3
inflammasome
activation.
Results
significantly
dysfunction,
increased
blood
flow,
mitigated
pathological
changes
tissues
edema
mice.
Network
pharmacology
indicated
that
might
exert
anti-inflammatory
anti-oxidative
stress
effects
through
TNF
NF-κB.
Proteomic
analysis
showed
differential
between
ZL
group
mainly
enriched
immune-inflammatory
response,
main
mechanism
which
assembly
inflammasome.
Subsequent
vivo
corroborated
remarkably
attenuated
inflammation
damage
tissues.
Further
demonstrated
inhibited
NLRP3/Caspase-1/GSDMD
signaling
pathway
protein
expression.
TEM
results
also
verified
pyroptosis
cells.
Conclusion
Our
suggest
regulating
axis,
inhibiting
pyroptosis,
thereby
relieving
dysfunction
injury
Disease Markers,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 10
Published: June 24, 2022
The
eye
is
one
of
the
most
important
organs
human
body.
Eye
diseases
are
closely
related
to
other
systemic
diseases,
both
which
influence
each
other.
Numerous
lead
special
clinical
manifestations
and
complications
in
eyes.
Typical
include
diabetic
retinopathy,
hypertensive
thyroid
associated
ophthalmopathy,
optic
neuromyelitis,
Behcet’s
disease.
Systemic
disease-related
ophthalmopathy
usually
a
chronic
disease,
analysis
imaging
markers
helpful
for
comprehensive
diagnosis
these
diseases.
Recently,
artificial
intelligence
(AI)
technology
based
on
deep
learning
has
rapidly
developed,
leading
numerous
achievements
arousing
widespread
concern.
Presently,
AI
made
significant
progress
research
ophthalmopathy;
however,
there
also
many
limitations
challenges.
This
article
reviews
achievements,
limitations,
future
prospects
image
ophthalmopathy.
