Chronobiotic and cytoprotective activity of melatonin in the cardiovascular system. Doses matter

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 9, 2024

Language: Английский

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Exploring potential biomarkers for acute myocardial infarction by combining circadian rhythm gene expression and immune cell infiltration

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression identify highly specific Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes-JUN, NAMPT, S100A8, SERPINA1, VCAN identified contributors this process. Functional enrichment analyses suggest these significantly influence cytokine chemokine production responses. Immune assessments using ssGSEA indicated elevated levels neutrophils, macrophages, eosinophils patients. Additionally, we potential therapeutic implications 13 pivotal miRNAs 10 candidate drugs targeting genes. The Benjamini-Hochberg method was employed adjust multiple testing, retained statistical significance. RT-qPCR analysis further confirmed upregulation hypoxic conditions, compared controls. Collectively, our findings highlight critical role CRGs AMI, providing a foundation improved approaches novel targets.

Language: Английский

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Circadian Disruptions and Their Impact on Inflammatory Pathways, Neuroendocrine Dysregulation, and Cardiovascular Risk: A Systematic Review and Meta-Analysis

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(2), P. 674 - 681

Published: March 11, 2025

Background: Circadian disruptions, such as shift work, sleep irregularity, and chronic circadian misalignment, have been increasingly linked to adverse health outcomes, particularly affecting cardiovascular health. These disruptions alter inflammatory neuroendocrine pathways, which may accelerate disease risk. This meta-analysis aimed synthesize evidence on the association between markers, dysregulation, outcomes. Methods: A systematic literature search was conducted using PubMed, Web of Science, PsycINFO, Cochrane Library, Scopus databases, covering studies published 2015 2024. Eligible included observational experimental designs assessing impact documented markers (CRP, IL-6, TNF-α), biomarkers (cortisol, melatonin), outcomes (coronary heart disease, events, metabolic risk). Quality assessment performed Risk Bias Tool for Newcastle-Ottawa Scale (NOS) studies. Due substantial heterogeneity across studies, a narrative synthesis supported by descriptive statistics, correlation analysis, visual comparative techniques applied, rather than formal pooled effect size calculation. Results: Eight (n=744) reported increased TNF-α) in (p < 0.05–0.01). Misalignment altered cortisol rhythms secretion 0.05). Correlation analysis showed moderate positive dysregulation Shift work misalignment had highest risk, with stronger effects longer Most low-to-moderate bias. Conclusions: contribute inflammation, Maintaining stability is crucial, workers. High-quality are needed targeted interventions.

Language: Английский

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Endothelial Dysfunction in Acute Myocardial Infarction: A Complex Association With Sleep Health, Traditional Cardiovascular Risk Factors and Prognostic Markers

Clinical Cardiology, Journal Year: 2025, Volume and Issue: 48(1)

Published: Jan. 1, 2025

ABSTRACT Background Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). Hypothesis AMI patients experience endothelial dysfunction (EndDys), associated traditional CV risk factors sleep patterns. EndFx may also predict short mid‐term outcomes. Methods was assessed in 63 (56.2 ± 7.6 years) using the Endothelium Quality Index (EQI). Sleep quality quantity were evaluated objective (actigraphy) subjective (Pittsburgh questionnaire) measures. Cardiorespiratory fitness quantified through 6‐min walking test. Cardiac left ventricular ejection fraction. Results Following AMI, tended to EndDys (EQI = 1.4 0.7). A severe observed 23.8% ( n 15), while mild present 63.49% 40). Furthermore, significantly (i.e., low physical activity level [12.8%], age [−4.2%], smoking [−0.7%]) (R 2 adjusted 0.50, p < 0.001). Patients had poor 0.001) efficiency 0.016) compared healthy persons. exhibited lower cardiorespiratory those 0.017). during follow‐up period (nearly 4 months) PCI, major adverse cardiac events four EndDys. Conclusions Our results emphasize importance adequate an active lifestyle, notably practice, as modifiable elements enhance EndFx, which regarded predictive tool AMI. However, other remain be elucidated predictors risk. Trial Registration The study protocol registered Pan African Clinical Registry under trial ID: PACTR202208834230748.

Language: Английский

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The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study

Journal of Medical Internet Research, Journal Year: 2025, Volume and Issue: 27, P. e63897 - e63897

Published: Feb. 4, 2025

Background Myocardial infarction (MI) is a medical emergency resulting from coronary artery occlusion. Patients with acute MI often experience disturbed sleep and circadian rhythm. Most previous studies assessed the premorbid rhythm of patients their correlations cardiovascular disease. However, little known about post-MI impacts on prognosis. The use actigraphy different algorithms to evaluate after has potential for predicting outcomes preventing future disease progression. Objective We aimed how patterns disrupted affect prognosis MI, using heart rate variability (HRV). Nonparametric analysis data was performed examine patients. Methods in intensive care unit (ICU) were enrolled alongside age- gender-matched healthy controls. Actigraphy used rhythm, while HRV monitored 24 hours assess autonomic nerve function. indicators calculated quantify active-rest patterns, including interdaily stability, intradaily variability, most active 10 consecutive (M10), least 5 (L5), relative amplitude, actigraphic dichotomy index. Follow-ups conducted at 3 6 months discharge prognosis, duration current admission, number readmission ICU catheterization. Independent sample t tests covariance compare group differences. Pearson correlation explore parameters Results study included 34 (mean age 57.65, SD 9.03 years) 17 had significantly more wake onset, an increased awakenings, lower efficiency than Circadian revealed daytime activity Moreover, these amplitude index higher midpoint M10, suggesting less changes, fragmentation rest-activity delayed Furthermore, significant found between analysis, nighttime activity, time M10 L5, activitySD, patient Conclusions experienced worse compared Our actigraphy-based reduced activities, greater fluctuation hourly weak which correlated evaluation can serve as valuable indicator should be further studied.

Language: Английский

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Seasonal Stability of the Circadian Rhythm in Patients with Type I Myocardial Infarction

Reviews in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 25(7)

Published: July 10, 2024

Background: A circadian rhythm of myocardial infarction has been described but there is little data on its relation with seasons and months. Methods: From June 2013 to 2018, we analyzed the alerts for acute ST-segment elevation (STEMI) in a Spanish region 6.64 million inhabitants, universal health coverage, an organized STEMI reperfusion network. We selected those patients which identifiable culprit plaque. Results: recruited 6765 cases due type I (type-I AMI), mean age 63.2 years (range 17–101, standard deviation [SD] 13.7), 5238 were males (77.4%) 2801 (41.9%) 65 or older. The hourly distribution followed fixed pattern all months, most events occurring between 6:00 AM 4:00 PM, peak at approximately 01:00 PM valley 10:00 06:00 AM. No significant difference was found when comparing time first medical contact July (the month more daylight hours) December shortest days). differences male female patients, aged older younger patients. There close correlation number per during day (6 6 r = 0.988, p 0.001) night AM, 0.944, < 0.001), different slopes regression lines (t-test, so that day-night occurrences increased total incidence. Conclusions: presentation not influenced by sex age. incidence times year does affect terms shape curve presentation, although diurnal increase than nocturnal events, suggesting triggers are likely act vulnerable periods as determined circadian-based rhythm.

Language: Английский

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Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 28, 2024

Long-term consumption of Western Diet (WD) is a well-established risk factor for the development cardiovascular disease (CVD); however, there paucity studies on long-term effects WD pathophysiology CVD and sex-specific responses. Our study aimed to investigate pathophysiological changes in left ventricular (LV) function using transthoracic echocardiography (ECHO) LV tissue transcriptomics WD-fed C57BL/6 J mice 125 days, starting at age 300 through 425 days. In female mice, diet showed structure possible HFpEF-like phenotype with compensatory cardiac structural later life. male ECHO revealed an HFrEF-like life without detectable alterations. The transcriptomic profile sex-associated dichotomy function. Specifically, 530-day, exhibited differentially expressed genes (DEGs), which were overrepresented pathways associated endocrine function, signal transduction, cardiomyopathies. At 750 dysregulation several involved various lipid, glucagon, glutathione metabolic pathways. 530 most distinctive set DEGs abundance related circadian rhythms. 640 altered energy metabolism remodeling. demonstrated distinct age-associated differences structure, transcriptome signature between mice.

Language: Английский

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Causal Effects of Air Pollution, Noise, and Shift Work on Unstable Angina and Myocardial Infarction: A Mendelian Randomization Study

Toxics, Journal Year: 2024, Volume and Issue: 13(1), P. 21 - 21

Published: Dec. 28, 2024

Cardiovascular disease continues to be a major contributor global morbidity and mortality, with environmental occupational factors such as air pollution, noise, shift work increasingly recognized potential contributors. Using two-sample Mendelian randomization (MR) approach, this study investigates the causal relationships of these risk risks unstable angina (UA) myocardial infarction (MI). Leveraging single nucleotide polymorphisms (SNPs) genetic instruments, comprehensive MR was used assess influence four pollutants (PM2.5, PM10, NO2, NOx), on infarction. Summary statistics were derived from large genome-wide association studies (GWASs) UK Biobank FinnGen consortium (Helsinki, Finland), replication using an independent GWAS data source for The inverse-variance weighted (IVW) approach demonstrated significant positive correlation between increased both (OR 95% CI: 1.62 [1.12–2.33], p = 0.010) 1.46 [1.00–2.14], 0.052). MR-PRESSO analysis identified outliers, after correction, strengthened 1.58 [1.11–2.27], 0.017). No notable associations pollution or noise either outcome. findings supported possible link 1.41 [1.08–1.84], 0.012). These results provide novel evidence supporting likely factor infarction, underscoring need targeted public health strategies mitigate its cardiovascular impact. However, further investigation is necessary elucidate role in outcomes.

Language: Английский

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Alterações pressóricas circadianas na Apneia Obstrutiva do Sono na população pediátrica

Revista Eletrônica Acervo Saúde, Journal Year: 2024, Volume and Issue: 24(7), P. e16889 - e16889

Published: July 31, 2024

Objetivos: Avaliar a relação das medidas pressóricas circadianas em crianças com apneia obstrutiva do sono (AOS) e as consequências que sua desregulação pode provocar longo prazo. Métodos: Foram utilizadas bases de dados BVS, PubMed, MEDLINE, LILACS Uptodate, incluindo estudos publicados partir janeiro 2019, inglês português. Para definir AOS, os artigos utilizaram critérios da polissonografia para diagnóstico monitorização ambulatorial pressão arterial (MAPA) o registro dos valores PA ao dia. Resultados: Em 9 AOS estava associada à alteração nos 24 horas, sendo pico ocorre no início manhã noite durante REM. Essa população também apresenta uma diminuição descenso noturno. variabilidade está mais fortemente piores desfechos cardiovasculares quando comparada elevada isoladamente. Considerações finais: Os confirmam alterações na faixa etária pediátrica, destacando necessidade investigar sintomas consultas pediátricas, realizar um tratamento precoce assim, evitar complicações indesejadas futuro.

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Combining Circadian Rhythm-Related Gene Expression and Immune Infiltration to Identify Diagnostic Biomarkers in Acute Myocardial Infarction

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Current diagnostic biomarkers for acute myocardial infarction (AMI), such as troponins, often lack specificity, leading to false positives under non-cardiac conditions. Recent studies have implicated circadian rhythm and immune infiltration in the pathogenesis of AMI. This study hypothesizes that analyzing interplay between rhythm-related gene expression can pinpoint more accurate Our results demonstrated differential 15 genes (CRGs) AMI patients healthy individuals, with five key genes—JUN, NAMPT, S100A8, SERPINA1, VCAN—emerging central this process. Functional enrichment analyses suggest these significantly influence cytokine chemokine production responses. Immune assessments using ssGSEA indicated elevated levels neutrophils, macrophages, eosinophils patients. Additionally, we identified potential therapeutic implications 13 pivotal miRNAs 10 candidate drugs targeting genes. RT-qPCR analysis further confirmed upregulation hypoxic conditions, compared controls. Collectively, our findings highlight critical role CRGs AMI, offering new insights into its diagnosis targets.

Language: Английский

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