Key Insights into Respiratory Virus Testing: Sensitivity and Clinical Implications

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 63 - 63

Published: Jan. 2, 2025

Acute respiratory infections are a significant challenge in primary care and hospital settings. Viruses the most common etiology overlapping symptomatology among major viruses, such as influenza, severe acute syndrome coronavirus 2, syncytial virus, requires use of diagnostic tests that deliver early accurate results. With increasing availability rapid antigen (RATS), it is tempting to prefer them over polymerase chain reaction (PCR) tests. However, compelling arguments support existing recommendations some European countries maintain PCR testing for patient management throughout year. RATs show sensitivities below 30% with lower viral loads, which can have clinical implications. perform well at cycle threshold (Ct) values, sensitivity reaching 97.9% Ct values 20, drops significantly above 25. Factors affecting load include disease stage, vaccination status, variants, all compromise accuracy Multi-target effectively overcome these issues, ensuring reliable diagnosis. Additionally, detection paucisymptomatic cases essential settings facilitate isolation prevent secondary infections. Economic analyses comprehensive tests, triplex-type detecting SARS-CoV-2, influenza RSV, first-line approach, they reduce case numbers healthcare resource utilization. Maintaining year-round therefore crucial effective

Language: Английский

Unraveling the Impact of COVID-19 on Rheumatoid Arthritis: Insights from Two Romanian Hospitals—Preliminary Results

Biomedicines, Journal Year: 2024, Volume and Issue: 12(9), P. 2145 - 2145

Published: Sept. 21, 2024

Rheumatoid arthritis (RA) patients are at heightened risk of Coronavirus Disease-19 (COVID-19) complications due to immune dysregulation, chronic inflammation, and treatment with immunosuppressive therapies. This study aims characterize the clinical laboratory parameters RA diagnosed COVID-19, identify predictive factors for severe forms this infection patients, determine if any therapy is associated worse COVID-19 outcomes.

Language: Английский