Gene Expression After Exercise Is Disrupted by Early‐Life Stress

Developmental Psychobiology, Journal Year: 2025, Volume and Issue: 67(1)

Published: Jan. 1, 2025

ABSTRACT Exercise can be leveraged as an important tool to improve neural and psychological health, either on its own or bolster the efficacy of evidence‐based treatment modalities. Research in both humans animal models shows that positive experiences, such exercise, promote neuroprotection while, contrast, aversive particularly those early development, are often neurologically psychologically disruptive. In current study, we employed a preclinical model investigate therapeutic benefits exercise gene expression brains adult rats. Long Evans rats were exposed maltreatment stress nurturing care during infancy, with some later given voluntary running wheels aerobic intervention from Postnatal Days 70 90. Our results showed irisin expression, which promotes neuroprotection, was differentially affected by exposure stress. We add rapidly growing area research neuroprotective shed light molecular mechanisms may affect different individuals.

Language: Английский

The role of epigenetic mechanisms in the long‐term effects of early‐life adversity and mother–infant relationship on physiology and behavior of offspring in laboratory rats and mice

Developmental Psychobiology, Journal Year: 2024, Volume and Issue: 66(3)

Published: March 12, 2024

Abstract Maternal care during the early postnatal period of altricial mammals is a key factor in survival and adaptation offspring to environmental conditions. Natural variations maternal experimental manipulations with maternal–child relationships modeling early‐life adversity (ELA) laboratory rats mice have strong long‐term influence on physiology behavior mice. This literature review devoted latest research role epigenetic mechanisms these effects ELA mother–infant relationship, focus regulation hypothalamic–pituitary–adrenal axis brain‐derived neurotrophic factor. An important part this dedicated pharmacological interventions editing as tools for studying causal development physiological behavioral profiles. A special section manuscript will discuss translational potential discussed research.

Language: Английский