Neurotoxic reactive astrocytes are induced by activated microglia

Nature, Journal Year: 2017, Volume and Issue: 541(7638), P. 481 - 487

Published: Jan. 1, 2017

Language: Английский

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Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

Immunity, Journal Year: 2014, Volume and Issue: 41(1), P. 14 - 20

Published: July 1, 2014

Language: Английский

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The biology and function of fibroblasts in cancer

Nature reviews. Cancer, Journal Year: 2016, Volume and Issue: 16(9), P. 582 - 598

Published: Aug. 23, 2016

Language: Английский

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Macrophage Polarization

Annual Review of Physiology, Journal Year: 2016, Volume and Issue: 79(1), P. 541 - 566

Published: Nov. 4, 2016

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as are sufficiently plastic integrate multiple signals, such those from microbes, damaged tissues, the normal tissue environment. Three broad pathways control polarization: epigenetic cell survival that prolong or shorten macrophage development viability, microenvironment, extrinsic factors, microbial products cytokines released inflammation. A plethora of advances provided framework for rationally purifying, describing, manipulating polarization. Here, I assess current state knowledge about enumerate major questions regulate physiology tissues.

Language: Английский

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NF-κB, inflammation, immunity and cancer: coming of age

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(5), P. 309 - 324

Published: Jan. 22, 2018

Language: Английский

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity, Journal Year: 2017, Volume and Issue: 47(3), P. 566 - 581.e9

Published: Sept. 1, 2017

Language: Английский

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Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Nature Reviews Neurology, Journal Year: 2020, Volume and Issue: 17(3), P. 157 - 172

Published: Dec. 14, 2020

Language: Английский

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Reactive Astrocytes: Production, Function, and Therapeutic Potential

Immunity, Journal Year: 2017, Volume and Issue: 46(6), P. 957 - 967

Published: June 1, 2017

Language: Английский

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Immune attack: the role of inflammation in Alzheimer disease

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(6), P. 358 - 372

Published: May 20, 2015

Language: Английский

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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

Frontiers in Immunology, Journal Year: 2014, Volume and Issue: 5

Published: Oct. 17, 2014

Studies on monocyte and macrophage biology differentiation have revealed the pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain integrity by eliminating/repairing damaged cells matrices. In this M2-like mode they can also promote tumor growth. Conversely, M1-like macrophages key effector for elimination pathogens, virally infected, cancer Macrophage from monocytes occurs in concomitance with acquisition a functional phenotype depends microenvironmental signals, thereby accounting many apparently opposed functions. Many questions arise. When differentiate into (concomitantly adopting specific program, M1 or M2), do all die during inflammatory reaction, some them survive? Do those survive become quiescent macrophages, able to react as naïve new challenge? Or, monocyte-derived conserve “memory” their past activation? This review will address important under general framework role initiation, development, resolution chronicization inflammation.

Language: Английский

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