The use of stem cells in the treatment of diabetes mellitus and its complications - review DOI Creative Commons
Łukasz Ochyra, Anna Łopuszyńska

Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 74, P. 51736 - 51736

Published: June 11, 2024

Introduction and purpose Diabetes is a disease resulting from impaired action or secretion of insulin. The number patients currently amounts to approximately 422 million, 1.5 million deaths per year are directly attributed this disease. significantly reduces the quality life and, if poorly controlled, can lead serious complications. Mesenchymal stem cells multipotent capable differentiation. They have ability self-renew modulating function. There reports that they be used in treatment aim review was present new method therapy their possible effects. Material methods based on articles obtained PubMed scientific database years 2015-2023, using following keywords: diabetes mellitus, cells, Results Implanted able transform into produce secrete insulin, also enable better glycemic control. alleviate chronic inflammation reduce fibrosis. Taking account complications occur during long-term diabetes, use may associated with improving function specific organs tissues such as kidneys, heart, eyes nerves. Studies report positive effect these healing process wounds ulcers. Conclusions Stem promising object analysis. control glycemia functioning nerves, accelerate wound healing, but further, extensive research needed assess effectiveness safety therapy.

Language: Английский

Targeting the tumor microenvironment: Potential strategy for cancer therapeutics DOI Creative Commons
Quratulain Babar, Ayesha Saeed, Tanveer A. Tabish

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2023, Volume and Issue: 1869(6), P. 166746 - 166746

Published: May 7, 2023

Cellular and stromal components including tumor cells, immune mesenchymal cancer-linked fibroblasts, extracellular matrix, constituent microenvironment (TME). TME plays a crucial role in reprogramming initiation, uncontrolled proliferation, invasion metastasis as well response to therapeutic modalities. In recent years targeting the has developed potential strategy for treatment of cancer because its life-threatening functions restricting development modulating responses standard-of-care medicines. Cold atmospheric plasma, oncolytic viral therapy, bacterial nano-vaccine, repurposed pharmaceuticals with combination antiangiogenic drugs, immunotherapies are among most effective therapies directed by that have either been clinically authorized or currently being studied. This article discusses above-mentioned light TME. We also cover problems related TME-targeted therapies, future insights practical uses this rapidly growing field.

Language: Английский

Citations

54
The use of stem cells in the treatment of diabetes mellitus and its complications - review DOI Creative Commons
Łukasz Ochyra, Anna Łopuszyńska

Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 74, P. 51736 - 51736

Published: June 11, 2024

Introduction and purpose Diabetes is a disease resulting from impaired action or secretion of insulin. The number patients currently amounts to approximately 422 million, 1.5 million deaths per year are directly attributed this disease. significantly reduces the quality life and, if poorly controlled, can lead serious complications. Mesenchymal stem cells multipotent capable differentiation. They have ability self-renew modulating function. There reports that they be used in treatment aim review was present new method therapy their possible effects. Material methods based on articles obtained PubMed scientific database years 2015-2023, using following keywords: diabetes mellitus, cells, Results Implanted able transform into produce secrete insulin, also enable better glycemic control. alleviate chronic inflammation reduce fibrosis. Taking account complications occur during long-term diabetes, use may associated with improving function specific organs tissues such as kidneys, heart, eyes nerves. Studies report positive effect these healing process wounds ulcers. Conclusions Stem promising object analysis. control glycemia functioning nerves, accelerate wound healing, but further, extensive research needed assess effectiveness safety therapy.

Language: Английский

Citations

1