Ambient particulate air pollution and the intestinal microbiome; a systematic review of epidemiological, in vivo and, in vitro studies

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 162769 - 162769

Published: March 11, 2023

A healthy indigenous intestinal microbiome is indispensable for intra- and extra-intestinal human health. Since well-established factors such as diet antibiotic use only explain 16 % of the inter-individual variation in gut composition, recent studies have focused on association between ambient particulate air pollution microbiome. We systematically summarize discuss all evidence concerning effect bacterial diversity indices, specific taxa, potential underlying mechanisms. To this end, possibly relevant publications published February 1982 January 2023 were screened, eventually, 48 articles included. The vast majority (n = 35) these animal studies. exposure periods investigated epidemiological 12) ranged from infancy through elderly. This systematic review found that indices generally negatively associated with studies, an increase taxa belonging to Bacteroidetes (two studies), Deferribacterota (one study), Proteobacteria (four a decrease Verrucomicrobiota no consensus Actinobacteria (six studies) Firmicutes (seven studies). There was unequivocal Only one study humans examined possible mechanism; yet, included vitro depicted higher damage, inflammation, oxidative stress, permeability exposed versus unexposed animals. Overall, population-based showed dose-related continuum short- long-term lower shifts over entire life course.

Language: Английский

---

The importance of the gut microbiome and its signals for a healthy nervous system and the multifaceted mechanisms of neuropsychiatric disorders

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 5, 2024

Increasing evidence links the gut microbiome and nervous system in health disease. This narrative review discusses current views on interaction between microbiota, intestinal epithelium, brain, provides an overview of communication routes signals bidirectional interactions microbiota including circulatory, immunological, neuroanatomical, neuroendocrine pathways. Similarities differences healthy humans mice exist that are relevant for translational gap non-human model systems patients. There is increasing spectrum metabolites neurotransmitters released and/or modulated by both homeostatic pathological conditions. Dysbiotic disruptions occur as consequences critical illnesses such cancer, cardiovascular chronic kidney disease but also neurological, mental, pain disorders, well ischemic traumatic brain injury. Changes (dysbiosis) a concomitant imbalance release mediators may be cause or consequence diseases central increasingly emerging to disruption physiological function, alterations nutrition intake, exposure hypoxic conditions others, observed disorders. Despite generally accepted importance microbiome, not fully understood. Elucidating these signaling pathways more detail offers novel mechanistic insight into pathophysiology multifaceted aspects

Language: Английский

---

A systematic review of the association between environmental risk factors and the development of irritable bowel syndrome

Journal of Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 39(9), P. 1780 - 1787

Published: May 3, 2024

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with roots in genetic, immune, psychological, and dietary factors. Recently, the potential correlation between environmental exposures, such as air pollution, IBS has gained attention. This review aimed to systematically examine existing studies on factors associated IBS, elucidating this interplay guiding future research.

Language: Английский

---

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 18, 2025

ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized

Language: Английский

---

The gut microbiome and the brain

Current Opinion in Supportive and Palliative Care, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Purpose of review The importance the gut microbiome for human health and well-being is generally accepted, elucidating signaling pathways between host offers novel mechanistic insight into (patho)physiology multifaceted aspects healthy aging brain functions. Recent findings tightly linked with nervous system, microbiota are increasingly emerging as important regulators emotional cognitive performance. They send receive signals bidirectional communication via immunological, neuroanatomical, humoral pathways. composition spectrum metabolites neurotransmitters that they release changes increasing age, nutrition, hypoxia, other pathological conditions. Changes in (dysbiosis) associated critical illnesses such cancer, cardiovascular, chronic kidney disease but also neurological, mental, pain disorders, well chemotherapies antibiotics affecting development function. Summary Dysbiosis a concomitant imbalance mediators both causes consequences diseases brain. Understanding microbiota’s role pathogenesis these disorders will have major clinical implications offer new opportunities therapeutic interventions.

Language: Английский

---

The relationship between prenatal drought exposure and the diversity and composition of gut microbiome in pregnant women and neonates

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

---

Sex differences in the association between long-term ambient particulate air pollution and the intestinal microbiome composition of children

Environment International, Journal Year: 2025, Volume and Issue: 199, P. 109457 - 109457

Published: April 12, 2025

Language: Английский

---

Altered Gut Microbiota Composition Is Associated with Difficulty in Explicit Emotion Regulation in Young Children

Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2245 - 2245

Published: Sept. 6, 2023

Executive function (EF) consists of explicit emotion regulation (EER) and cognitive control (CC). Childhood EER in particular predicts mental physical health adulthood. Identifying factors affecting development has implications for lifelong health. Gut microbiota (GM) attracted attention as a potential biomarker risk problems Furthermore, GM is related to brain function/structure, which plays crucial role emotional processing. However, little known about how compositions are associated with the early childhood. Therefore, this study, we examined 257 children aged 3-4 investigate links between EF. EF was measured using Mother-Reported Behavior Rating Inventory Function-Preschool version. composition (alpha/beta diversity genus abundance) evaluated 16S rRNA gene sequencing compared EF-risk non-risk groups. Our results show that EER-risk (an index inhibitory self-control) had higher abundance genera Actinomyces Sutterella. Although have not established direct link CC risk, our findings indicate preschoolers closely processing EERrisk more inflammation-related bacteria.

Language: Английский

---

Newborn glomerular function and gestational particulate air pollution

EBioMedicine, Journal Year: 2024, Volume and Issue: 107, P. 105253 - 105253

Published: Aug. 23, 2024

Nephron number variability may hold significance in the Developmental Origins of Health and Disease hypothesis. We explore impact gestational particulate pollution exposure on cord blood cystatin C, a marker for glomerular function, as an indicator health at birth.

Language: Английский

---

In vitro-simulated intestinal flora fermentation of Porphyra haitanensis polysaccharides obtained by different assisted extractions and their fermented products against HT-29 human colon cancer cells

Food & Function, Journal Year: 2023, Volume and Issue: 14(24), P. 10747 - 10758

Published: Jan. 1, 2023

Herein, we studied the in vitro-simulated intestinal flora fermentation of Porphyra haitanensis polysaccharides (PHPs) with microwave, ultrasonic, ultra-high pressure-assisted extraction and protective effect their fermented products against HT-29 human colon cancer cells. The results showed that PHPs were largely degraded at 18 h stage ascending fermentation, further greatly increasing contents reducing sugars short-chain fatty acids (p < 0.05). Particularly, subjected to (UHP-PHP) highest sugar content 1.68 ± 0.01 mg mL-1 butyric acid 410.77 7.99 mmol mL-1. Moreover, UHP-PHP a better ratio Bacteroidetes/Firmicutes decreasing abundance Proteobacteria Escherichia coli. could protect cells by ROS levels concentration-dependent manner, especially descending for 24 h. This was related up-regulated apoptosis-related genes (Bax Bak), down-regulated protein expression Bcl-2 activation p-AKT protein, thereby promoting apoptosis Our can facilitate modification practical application development health improving products.

Language: Английский

---