Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(10)
Published: Oct. 1, 2023
Language: Английский
Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332523
Published: Aug. 23, 2024
Epidemiological and translational data increasingly implicate environmental pollutants in inflammatory bowel disease (IBD). Indeed, the global incidence of IBD has been rising, particularly developing countries, parallel with increased use chemicals synthetic materials daily life escalating pollution levels. Recent nationwide ecological studies have reported associations between agricultural pesticides IBD, Crohn’s disease. Exposure to other chemical categories also linked an risk IBD. To synthesise available identify knowledge gaps, we conducted a systematic review human that on impact outcomes. Furthermore, summarised vitro animal investigating mechanisms underlying these associations. The 32 included corroborate heavy transition metals, except zinc, air pollutants, per- polyfluorinated substances, are associated exposure being disease-related adverse outcomes as well. narrative preclinical suggests several overlapping associations, including intestinal permeability, systemic inflammation dysbiosis. A consolidated understanding exposures is key identification potentially modifiable factors inform strategies towards prediction, prevention mitigation
Language: Английский
Citations
10
Toxics, Journal Year: 2024, Volume and Issue: 12(3), P. 228 - 228
Published: March 21, 2024
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic worldwide. At same time, relationship between air pollution and likelihood of developing NAFLD has been a subject debate due to conflicting findings in previous observational research. Our objective was examine potential correlation pollutant levels risk European population by employing two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided summary statistics for various indicators (PM2.5, PM2.5 absorbance, PM2.5–10, PM10, NO2, NOx). Additionally, information on obtained from three studies, including one derivation set two validation sets. Heterogeneity, pleiotropy, sensitivity analyses were performed under different MR frameworks, instrumental variables associated with confounders (such as education, smoking, alcohol, BMI) detected tools. In set, causal relationships PM2.5, observed univariable (UVMR) (Odds Ratio (OR) = 1.99, 95% confidence interval (95% CI) [1.22–3.22], p 0.005; OR 2.08, CI [1.27–3.40], 0.004, respectively). After adjustment pollutants or alcohol intake frequency multivariable (MVMR), above genetic correlations disappeared. sets, null associations remained UVMR. analysis using data did not provide evidence association population. epidemiological studies could be partly attributed confounders.
Language: Английский
Citations
5
Environmental Research, Journal Year: 2024, Volume and Issue: 258, P. 119415 - 119415
Published: June 19, 2024
Language: Английский
Citations
5
International Journal of Surgery, Journal Year: 2024, Volume and Issue: unknown
Published: March 25, 2024
Background: Although the beneficial properties of vitamin D in anti-inflammation and immunity-modulation are promising management inflammatory bowel disease (IBD), data were limited for critical IBD prognosis. The association between serum levels risk resection individuals with remains largely unknown. Materials Methods: We performed a longitudinal cohort study among 5474 UK Biobank. Serum 25-hydroxyvitamin [25(OH)D] was measured using direct competitive chemiluminescent immunoassay. Bowel events ascertained via national inpatient data. Multivariable-adjusted Cox proportional hazard regression used to examine 25(OH)D risk, presented ratios (HRs) 95% confidence intervals (CIs). Restricted cubic spline (RCS) evaluate dose-response associations. Results: During mean follow-up 13.1 years, we documented 513 incident cases. Compared participants deficiency, non-deficient showed significantly reduced (HR 0.72, CI 0.59-0.87, P =0.001), Crohn’s (CD, HR 0.74, 0.56-0.98, =0.038), ulcerative colitis (UC, 0.73, 0.57-0.95, =0.020). When comparing extreme quintiles level, 34% (95% 11%-51%, =0.007) UC 46% 19%-64%, =0.003), while this not significant CD 0.93, 0.59-1.45, =0.740). Linear associations observed RCS curve (all P-nonlinearity>0.05). Conclusion: Increased level is independently associated IBD. This but may be stable CD. Vitamin deficiency factor IBD, an effective metric predicting risk-screening surgical events.
Language: Английский
Citations
4
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 13, 2025
Liver is an important target organ of ambient fine particulate matter (PM2.5). Numerous studies have shown that PM2.5 exposure can cause liver lipid metabolism disorders and other damage in mammals. However, the impact on health during pregnancy, a sensitive life stage, remains understudied, underlying mechanisms are also unknown. Given critical role adenosine 5'-monophosphate activated protein kinase (AMPK) regulating inflammation, we hypothesize AMPK activation may mitigate maternal hepatic disorders, reduce attenuate fibrosis induced by pregnancy. To test this hypothesis, pregnant C57BL/6 mice were randomly assigned to 4 groups: filtered air (FA) + NS (normal saline), PM2.5+NS, FA AICAR (acadesine, activator), PM2.5+AICAR. PM2.5+NS PM2.5+AICAR groups continuously exposed with whole-body chamber, while two chamber. Simultaneously, received intraperitoneal injections agonist (200 mg/kg∙bw per day) from gestational day 13 (GD13) GD17, administered normal saline injection. We found dyslipidemia mice, which was alleviated treatment. Histopathological analysis showed pregnancy deposition biochemical assays revealed triglyceride cholesterol levels significantly increased after PM2.5, whereas treatment ameliorated Furthermore, disrupted expression key genes proteins associated synthesis, fibrosis, mitigated these effects. These findings demonstrated ameliorates reduces attenuates caused be action for injury
Language: Английский
Citations
0
Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(6), P. 1861 - 1868
Published: April 25, 2024
Language: Английский
Citations
3
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 16, 2025
Air pollution, especially particulate matter (PM), is one of the most common risk factors for global burden disease. However, its effect on digestive diseases unclear. Herein, we attempt to explore this issue by reviewing existing evidence from published meta-analyses. We conducted a systematic literature search identify all relevant meta-analyses regarding association air pollution with diseases, and summarize their major findings. assessed methodological quality included using AMSTAR-2 GRADE tools, respectively, overlap primary studies was GROOVE tool. Nine were in our analysis, containing 43 high overlap. In meta-analyses, critically low moderate, very moderate. The exposure primarily PM2.5. Seven, four, meta-analysis investigated liver gastrointestinal pancreatic respectively. PM2.5 significantly associated dysfunction, chronic cancer, colorectal but not oesophagus gastric or cancer. Based moderate may contribute development some diseases.
Language: Английский
Citations
0
International Journal of Biometeorology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Language: Английский
Citations
0
The Lancet Regional Health - Europe, Journal Year: 2025, Volume and Issue: 52, P. 101264 - 101264
Published: March 14, 2025
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 14, 2025
Air pollution poses significant risks to human health, but its impact on gastrointestinal (GI) health remains underexplored. This study assesses the long-term effects of air GI diseases using data from China Health and Retirement Longitudinal Study (CHARLS). nationwide cohort utilized CHARLS participants recruited in 2011, followed by surveys 2013, 2015, 2018, 2020. Long-term exposure PM2.5, PM10, SO2, NO2, CO, O3 was assessed geocoded residential addresses linked quality data. Cox proportional hazards models subgroup interaction analyses were used evaluate associations between pollutants disease incidence, adjusting for demographic behavioral confounders. The incidence 21.4% among participants. PM2.5 (HR = 1.38, 95% CI: 1.33–1.44), PM10 1.31, 1.26–1.36), SO2 1.74, 1.68–1.81), NO2 1.21, 1.17–1.25), CO 1.48, 1.42–1.54), 0.56, 0.54–0.59) significantly associated with disease. Interaction showed that varied region, residence, smoking, alcohol use. Urban residents those living specific regions experienced stronger associations, likely due higher levels different environmental factors. Smokers users also more susceptible adverse pollutants. multiple increases risk diseases, while ozone may potentially offer some protective effects. Public measures reduce pollution, especially urban areas, protect high-risk groups are urgently needed.
Language: Английский
Citations
0