Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(10)
Published: Oct. 1, 2023
Language: Английский
JGH Open, Journal Year: 2025, Volume and Issue: 9(5)
Published: May 1, 2025
ABSTRACT Background Recent shifts in the global epidemiology of inflammatory bowel disease (IBD), particularly emerging industrialized nations like China, underscore need for in‐depth analysis. Methods Utilizing Global Burden Of Disease (GBD) 2021 database, we systematically examined IBD incidence, prevalence, death rates, and disability‐adjusted life years (DALYs) across Global, different social development index (SDI) regions, countries from 1990 to 2021. Age‐standardized rates (ASR) statistical metrics (APC, EAPC, AAPC) were employed assess trends development, a Bayesian age‐period‐cohort (BAPC) model was used forecast future scenarios. Results In 2021, highest incidence observed Canada (26.83/100000), Greenland (24.57/100000), New Zealand (23.69/100000), markedly contrasting China's rate 1.4/100000. Globally, increased modestly 4.22/100000 4.45/100000 (EAPC = 0.29%). China experienced more pronounced rise, with jumping 0.74/100000 1.4/100000 2.93%). Notably, also witnessed substantial declines deaths (56.00%) DALYs (58.22%). The Middle SDI region exhibited greater magnitude change than other regions. temporal prevalence are predominantly influenced by period up year 2015. between ages 15 49, projected remain consistent current standards, while predicted exhibit sustained decline. Conclusion Despite notable increase significant reductions mortality morbidity demonstrate effectiveness medical interventions health system improvements.
Language: Английский
Citations
0
Frontline Gastroenterology, Journal Year: 2024, Volume and Issue: 15(e1), P. e19 - e26
Published: April 26, 2024
The healthcare sector is a significant producer of greenhouse gas emissions. Gases that contribute to climate change include carbon dioxide, methane, nitrous oxide and chlorofluorocarbons. Climate will impact the types prevalence diseases seen in clinical practice. Practising preventive medicine gastroenterology can protect population health reduce need for services, thus reducing footprint sector. Increasing patient empowerment, making care pathways leaner minimising environmental treatments interventions could also make more sustainable.
Language: Английский
Citations
2
Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124694 - 124694
Published: Aug. 9, 2024
Micro-LiNiCoMnO
Language: Английский
Citations
2
Journal of Xenobiotics, Journal Year: 2024, Volume and Issue: 14(4), P. 1595 - 1612
Published: Oct. 21, 2024
Growing evidence suggests physiological and pathological functions of lung gut microbiomes in various pathologies. Epidemiological experimental data associate air pollution exposure with host microbial dysbiosis the lungs gut. Air through increased reactive oxygen species generation, disruption epithelial barrier integrity, systemic inflammation modulates imbalance. Microbiome balance is crucial regulating metabolic pathways to maintain health. proposed as a potential mechanism for air-pollution-induced modulation pulmonary disorders. Microbiome-based therapeutic approaches are increasingly gaining attention could have added value promoting This review summarizes discusses air-pollution-mediated microbiome alterations humans mice elaborates on their role health disease. We discuss summarize current literature, highlight important mechanisms that lead dysbiosis, elaborate potentially link context environmental exposures. Finally, we lung-liver-gut axis its pathophysiological implications pathologies dysbiosis.
Language: Английский
Citations
2
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(7), P. 167326 - 167326
Published: July 2, 2024
Language: Английский
Citations
1
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: March 28, 2024
In recent years, an increasing number of observational studies have reported the impact air pollution on autoimmune diseases (ADs). However, no Mendelian randomization (MR) been conducted to investigate causal relationships. To enhance our understanding causality, we examined relationships between particulate matter (PM) and nitrogen oxides (NO
Language: Английский
Citations
1
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(35), P. 15511 - 15521
Published: Aug. 15, 2024
Poor air quality is increasingly linked to gastrointestinal diseases, suggesting a potential correlation with human intestine health. However, this relationship remains largely unexplored due limited research. This study used controlled mouse model exposed cooking oil fumes (COFs) and metagenomics, transcriptomics, metabolomics elucidate interactions between microbiota host metabolism under environmental stress. Our findings reveal that short-term COF inhalation induces pulmonary inflammation within 3 days leads disturbances, elucidating pathway connecting respiratory exposure intestinal dysfunction. The intensity significantly correlates changes in tissue integrity, microbial composition, metabolic function. Extended of 7 disrupts alters tryptophan metabolism, further observed after 14 days, highlighting an adaptive response. These results highlight the vulnerability health airborne pollutants suggest through which inhaled may affect distant organ systems.
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Abstract Importance Evidence on physical activity recommendations for inflammatory bowel disease (IBD) patients is limited, with concerns about high-intensity activity. Objective To investigate the associations of accelerometer-measured moderate-to-vigorous (MVPA) resection risk and mortality among individuals IBD. Design, setting, participants This longitudinal cohort study collected data from 1,303 UK Biobank IBD diagnosis device-measured 2013 to 2015, follow-up examined until 2022. Exposures MVPA was classified based measured by wrist-worn accelerometers over a 7-day period. patterns were defined as inactive (< 150 minutes/week), active weekend warrior (≥ minutes/week, ≥50% total achieved in 1-2 days), regularly not warrior). Main Outcomes Measures The identified through operational records hospital inpatient National Health Service. Deaths documented linkage national death register. Associations estimated using multivariable Cox regression models nonlinearity assessed restricted cubic spline. Results During median 7.8 years, 56 incident cases 86 deaths documented. After adjustment, highest tertile duration had lower risks (HR, 0.44; 95% CI, 0.22-0.86) 0.49; 0.27-0.89) compared those lowest tertile. linearly associated (P non-linear = 0.13) while its dose-response relationship plateaus at approximately 58 min/day 0.02). Regarding patterns, pattern inversely 0.28; 0.12-0.65), both 0.37; 0.19-0.69) 0.53; 0.31-0.91) inactive. Conclusion relevance Longer reduced mortality. may be optimal choice IBD, still provides health benefits being
Language: Английский
Citations
1
Journal of Education Health and Sport, Journal Year: 2024, Volume and Issue: 60, P. 76 - 89
Published: Feb. 15, 2024
Introduction and objective Intense industrial development is contributing to increased emissions of air pollutants. Numerous studies indicate a link between pollution higher risk pulmonary cardiovascular diseases. Our goal analyze available scientific demonstrate the relationship developing complicating inflammatory bowel disease, colorectal cancer appendicitis. Brief description state knowledge Air global health challenge. Particles such as PM, nitrogen oxides, sulfur oxides or ozone have significant impact on health. Studies suggest intestinal diseases (IBD, CRC, appendicitis). pollutants can affect gut by causing inflammation, oxidative stress disruption microbiota. Exposure PM2.5 increase IBD, PM10 UC. There correlation rate hospitalization for IBD. In addition, exposure increases mortality. Short-term associated with more hospitalizations Summary real risk. Reducing could potentially reduce these their complications. Despite potential links, further research required better understand mechanisms action Urgent coordinated local needed protect public.
Language: Английский
Citations
0
Frontline Gastroenterology, Journal Year: 2023, Volume and Issue: 15(e1), P. e37 - e48
Published: Nov. 22, 2023
Trainee research networks are a collaborative effort to enable high-quality multicentre audits or that is more widely accessible trainees. Such lead, design and deliver at far higher scale than could be achieved locally carried out solely by There an increasing focus on delivering not only environmentally sustainable but also focuses areas can reduce the carbon footprint of service provision in gastroenterology hepatology. In this manuscript, we performed scoping review understand current evidence base impact hepatology services environment as well exploring any association between pollution climate change with gastrointestinal liver disease. We further discuss barriers researchers face research, limitation clinical guidelines related practicing how trainee ideally placed initiate developing, disseminating implementing best practice ‘green Gastroenterology’.
Language: Английский
Citations
1