Interference Mechanisms of Endocrine System and Other Systems of Endocrine‐Disrupting Chemicals in Cosmetics—In Vitro Studies DOI Creative Commons
Y Zhang, Lihong Tu,

Jian Chen

et al.

International Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Endocrine-disrupting chemicals (EDCs), found in various cosmetic products, interfere with the normal functioning of endocrine system, impacting hormone regulation and posing risks to human health. Common EDCs, such as ultraviolet (UV) filters, parabens, triclosan, can enter body through different routes, including skin absorption. Their presence has been linked adverse effects on reproduction, immune function, development. High-throughput vitro assays, using cell lines, were employed assess common EDCs ethylhexyl methoxycinnamate (EHMC), benzophenone-3 (BP-3), homosalate, parabens. Despite ongoing regulatory efforts, gaps persist understanding their long-term impacts, particularly when they are present mixtures or degradation products environment. This study focuses recent research investigate mechanisms which cosmetic-related disrupt system other physiological systems. The findings highlight broader systemic impact these chemicals, extending beyond include immune, reproductive, cardiovascular effects. underscores importance developing safer formulations enhancing public health protection, emphasizing need for stricter regulations.

Language: Английский

Mitochondrial malfunction-initiated Leydig cell premature senescence partially participates in 1-nitropyrene-evoked downregulation of steroidogenic synthases in testes DOI

Jian Li,

Xin Dong,

Lan Gao

et al.

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 225, P. 456 - 468

Published: Oct. 18, 2024

Language: Английский

Citations

1

Synergy under the Sun? Nanoplastics Enhance Estrogenicity of Common UV-Blocker DOI Creative Commons

Charles W. Schmidt

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(6)

Published: June 1, 2024

Human cells and zebrafish coexposed to nanoplastics the sunscreen ingredient homosalate showed more plastics in tissues, estrogenic activity, relevant gene expression changes than they after either exposure alone.

Language: Английский

Citations

0

P21-41 Deciphering sex-specific disruption in the nervous and reproductive systems through interactions of 4-methylbenzylidene camphor and nanoplastics in adult zebrafish DOI
Zhenlie Huang, Xian Huang, Zhongyi Li

et al.

Toxicology Letters, Journal Year: 2024, Volume and Issue: 399, P. S321 - S322

Published: Sept. 1, 2024

Language: Английский

Citations

0

Interference Mechanisms of Endocrine System and Other Systems of Endocrine‐Disrupting Chemicals in Cosmetics—In Vitro Studies DOI Creative Commons
Y Zhang, Lihong Tu,

Jian Chen

et al.

International Journal of Endocrinology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Endocrine-disrupting chemicals (EDCs), found in various cosmetic products, interfere with the normal functioning of endocrine system, impacting hormone regulation and posing risks to human health. Common EDCs, such as ultraviolet (UV) filters, parabens, triclosan, can enter body through different routes, including skin absorption. Their presence has been linked adverse effects on reproduction, immune function, development. High-throughput vitro assays, using cell lines, were employed assess common EDCs ethylhexyl methoxycinnamate (EHMC), benzophenone-3 (BP-3), homosalate, parabens. Despite ongoing regulatory efforts, gaps persist understanding their long-term impacts, particularly when they are present mixtures or degradation products environment. This study focuses recent research investigate mechanisms which cosmetic-related disrupt system other physiological systems. The findings highlight broader systemic impact these chemicals, extending beyond include immune, reproductive, cardiovascular effects. underscores importance developing safer formulations enhancing public health protection, emphasizing need for stricter regulations.

Language: Английский

Citations

0