Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants DOI Creative Commons

Clémence Rives,

Anne Fougerat,

Sandrine Ellero‐Simatos

et al.

Biomolecules, Journal Year: 2020, Volume and Issue: 10(12), P. 1702 - 1702

Published: Dec. 21, 2020

Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity insulin-resistance. NAFLD involves a large spectrum clinical conditions. These range from steatosis, benign disorder characterized by accumulation fat in hepatocytes, to non-alcoholic steatohepatitis (NASH), which inflammation, hepatocyte damage, fibrosis. NASH can further progress cirrhosis hepatocellular carcinoma. The etiology both genetic environmental factors, including an unhealthy lifestyle. Of note, eating clearly associated with development progression NASH. Both macronutrients (sugars, lipids, proteins) micronutrients (vitamins, phytoingredients, antioxidants) affect pathogenesis. Furthermore, some evidence indicates disruption homeostasis food contaminants, are risk factor candidates NAFLD. At molecular level, several models have been proposed for pathogenesis Most importantly, oxidative stress mitochondrial damage reported be causative initiation progression. aim this review provide overview contribution nutrients especially pesticides, how they may influence

Language: Английский

The Lancet Commission on pollution and health DOI Creative Commons
Philip J. Landrigan, Richard Fuller,

Nereus J R Acosta

et al.

The Lancet, Journal Year: 2017, Volume and Issue: 391(10119), P. 462 - 512

Published: Oct. 20, 2017

Language: Английский

Citations

4177
Global trends in pesticides: A looming threat and viable alternatives DOI

Akanksha Sharma,

Ananya Shukla,

Kriti Attri

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2020, Volume and Issue: 201, P. 110812 - 110812

Published: June 5, 2020

Language: Английский

Citations

431
A worldwide survey of neonicotinoids in honey DOI
Edward A. D. Mitchell, Blaise Mulhauser, Matthieu Mulot

et al.

Science, Journal Year: 2017, Volume and Issue: 358(6359), P. 109 - 111

Published: Oct. 5, 2017

Growing evidence for global pollinator decline is causing concern biodiversity conservation and ecosystem services maintenance. Neonicotinoid pesticides have been identified or suspected as a key factor responsible this decline. We assessed the exposure of pollinators to neonicotinoids by analyzing 198 honey samples from across world. found at least one five tested compounds (acetamiprid, clothianidin, imidacloprid, thiacloprid, thiamethoxam) in 75% all samples, 45% contained two more these compounds, 10% four five. Our results confirm bees their food throughout The coexistence other may increase harm pollinators. However, concentrations detected are below maximum residue level authorized human consumption (average ± standard error positive samples: 1.8 0.56 nanograms per gram).

Language: Английский

Citations

425
Pesticides: formulants, distribution pathways and effects on human health – a review DOI Creative Commons
Valeriya P. Kalyabina, Elena N. Esimbekova,

K. V. Kopylova

et al.

Toxicology Reports, Journal Year: 2021, Volume and Issue: 8, P. 1179 - 1192

Published: Jan. 1, 2021

Pesticides are commonly used in agriculture to enhance crop production and control pests. Therefore, pesticide residues can persist the environment agricultural crops. Although modern formulations relatively safe non-target species, numerous theoretical experimental data demonstrate that produce long-term negative effects on health of humans animals stability ecosystems. Of particular interest molecular mechanisms mediate start a cascade adverse effects. This is review latest literature consequences contamination crops by residues. In addition, we address issue implicit risks associated with formulations. The pesticides considered context Adverse Outcome Pathway concept.

Language: Английский

Citations

330
A critical review on the potential impacts of neonicotinoid insecticide use: current knowledge of environmental fate, toxicity, and implications for human health DOI
Darrin A. Thompson, Hans‐Joachim Lehmler, Dana W. Kolpin

et al.

Environmental Science Processes & Impacts, Journal Year: 2020, Volume and Issue: 22(6), P. 1315 - 1346

Published: Jan. 1, 2020

The review examines literature relevant to environmental fate, transformation, and toxicity, human exposure health risks of neonicotinoid insecticides.

Language: Английский

Citations

319
Environmental Chemical Contaminants in Food: Review of a Global Problem DOI Creative Commons
Lesa A. Thompson, Wageh Sobhy Darwish

Journal of Toxicology, Journal Year: 2019, Volume and Issue: 2019, P. 1 - 14

Published: Jan. 1, 2019

Contamination by chemicals from the environment is a major global food safety issue, posing serious threat to human health. These belong many groups, including metals/metalloids, polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs), perfluorinated compounds (PFCs), pharmaceutical and personal care products (PPCPs), radioactive elements, electronic waste, plastics, nanoparticles. Some of these occur naturally in environment, whilst others are produced anthropogenic sources. They may contaminate our food—crops, livestock, seafood—and drinking water exert adverse effects on It important perform assessments associated potential risks. Monitoring contamination levels, enactment control measures remediation, consideration sociopolitical implications vital provide safer globally.

Language: Английский

Citations

311
Occurrence of Neonicotinoid Insecticides in Finished Drinking Water and Fate during Drinking Water Treatment DOI Creative Commons

Kathryn L. Klarich,

Nicholas C. Pflug,

Eden M. DeWald

et al.

Environmental Science & Technology Letters, Journal Year: 2017, Volume and Issue: 4(5), P. 168 - 173

Published: April 5, 2017

Neonicotinoid insecticides are widespread in surface waters across the agriculturally intensive Midwestern United States. We report for first time presence of three neonicotinoids finished drinking water and demonstrate their general persistence during conventional treatment. Periodic tap grab samples were collected at University Iowa over 7 weeks 2016 (May–July) after maize/soy planting. Clothianidin, imidacloprid, thiamethoxam ubiquitously detected concentrations ranging from 0.24 to 57.3 ng/L. Samples along treatment train indicate no apparent removal clothianidin or with modest (∼50%). In contrast, all substantially lower City facility using granular activated carbon (GAC) filtration. Batch experiments investigated potential losses. Thiamethoxam losses due base-catalyzed hydrolysis under high-pH conditions lime softening. GAC rapidly nearly completely removed neonicotinoids. Clothianidin is susceptible reaction free chlorine may undergo least partial transformation chlorination. Our work provides new insights into distribution, while also identifying as a potentially effective management tool decreasing neonicotinoid water.

Language: Английский

Citations

245
Pollution and children's health DOI
Philip J. Landrigan, Richard Fuller,

Samantha Fisher

et al.

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 650, P. 2389 - 2394

Published: Oct. 2, 2018

Language: Английский

Citations

240
Neonicotinoid Residues in Fruits and Vegetables: An Integrated Dietary Exposure Assessment Approach DOI
Chensheng Lu, Chi-Hsuan Chang,

Cynthia Palmer

et al.

Environmental Science & Technology, Journal Year: 2018, Volume and Issue: 52(5), P. 3175 - 3184

Published: Jan. 30, 2018

Neonicotinoids have become the most widely used insecticides in world since introduced mid 1990s, yet extent of human exposure and health impacts is not fully understood. In this study, residues were analyzed seven neonicotinoids fruit vegetable samples collected from two cross-sectional studies: U.S. Congressional Cafeteria study (USCC) Hangzhou China (HZC) study. We then employed a relative potency factor method to integrate all each food sample using respective reference dose values as basis for summation. The findings compared with data published by Department Agriculture Pesticide Data Program (USDA/PDP). Imidacloprid thiamethoxam commonly detected fruits vegetables 66 51% detection HZC 52 53% USCC respectively. overall frequency USDA/PDP was much lower than those reported here or studies, imidacloprid being frequently neonicotinoid at 7.3%. high frequencies studies give us snapshot ubiquity use global agriculture make it clear that part dietary staple, possible implications individuals.

Language: Английский

Citations

232
Trends in neonicotinoid pesticide residues in food and water in the United States, 1999–2015 DOI Creative Commons
Hillary A. Craddock, Dina Huang, Paul C. Turner

et al.

Environmental Health, Journal Year: 2019, Volume and Issue: 18(1)

Published: Jan. 11, 2019

Neonicotinoids are a class of systemic insecticides widely used on food crops globally. These pesticides may be found in “off-target” items and persist the environment. Despite potential for extensive human exposure, there limited studies regarding prevalence neonicotinoid residues foods sold consumed United States. Residue data seven collected between 1999 2015 by US Department Agriculture’s Pesticide Data Program (PDP) were collated summarized year across various commodities, including fruit, vegetable, meat, dairy, grain, honey, baby food, as well water to qualitatively describe examine trends contamination frequency residue concentrations. The highest detection frequencies (DFs) neonicotinoids all commodities generally below 20%. Average DFs over entire study period, 1999–2015, domestic imported similar at 4.5%. For samples (both imported) imidacloprid was with overall 12.0%. However, higher observed specific commodity-neonicotinoid combinations such as: cherries (45.9%), apples (29.5%), pears (24.1%) strawberries (21.3%) acetamiprid; cauliflower (57.5%), celery (20.9%), (26.3%), cilantro (30.6%), grapes (28.9%), collard greens (24.9%), kale (31.4%), lettuce (45.6%), potatoes (31.2%) spinach (38.7%) imidacloprid. also detected organic (DF < 6%). Individual least 5% testing positive two or more included apples, celery, cherries. Generally, did not exceed Environmental Protection Agency tolerance levels. Increases both finished untreated from 2004 2011. Analysis PDP indicates that low levels present commonly-consumed fruits vegetables US. Trends suggest an increase use acetamiprid, clothianidin thiamethoxam replacements Given these findings, surveillance supply is warranted, biomonitoring assessment cumulative daily intake high risk groups, pregnant women infants.

Language: Английский

Citations

206