Cellular and molecular roles of reactive oxygen species in wound healing

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 19, 2024

Abstract Wound healing is a highly coordinated spatiotemporal sequence of events involving several cell types and tissues. The process wound requires strict regulation, its disruption can lead to the formation chronic wounds, which have significant impact on an individual’s health as well worldwide healthcare expenditure. One essential aspect within cellular molecular regulation pathogenesis that reactive oxygen species (ROS) oxidative stress. Wounding significantly elevates levels ROS, array various are involved in modulating process, such through antimicrobial activities signal transduction. However, many pathologies, ROS play antagonistic pleiotropic role healing, be pathogenic factor wounds. Whilst advances targeting stress led development novel pre-clinical therapeutic methods, due complex nature gaps knowledge remain concerning specific functions healing. In this review, we highlight current these functions, discuss potential future direction new studies, how pathways may targeted studies.

Language: Английский

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M.O.I.S.T. Concept for the Local Therapy of Chronic Wounds: An International Update

The International Journal of Lower Extremity Wounds, Journal Year: 2024, Volume and Issue: unknown

Published: April 4, 2024

Chronic wounds remain a significant clinical challenge both for those affected and healthcare systems. The treatment is often comprised complex. All patients should receive wound care that integrated into holistic approach involving local management addresses the underlying etiology provides gold standard therapy to support healing, avoid complications be more cost effective. There have been advances in medicine over last few decades. development of new technologies therapeutics also constantly increasing. To help standardize practice with regard multitude products, M.O.I.S.T. concept was developed by multidisciplinary expert group. M stands moisture balance, O oxygen I infection control, S supporting strategies, T tissue management. Since concept, which originated German-speaking countries, now intended provide professionals an adapted instrument used practice, recent update has undertaken group interdisciplinary experts align it international standards. can internationally as educational tool practical implementation modern concepts chronic routine practice.

Language: Английский

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Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 16, 2024

Abstract Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied developed as replacement red blood cells (RBCs) transport due to their similar oxygen-carrying capacities. However, applications HBOCs are hindered by vasoactivity, oxidative toxicity, relatively short circulatory half-life. With advancements nanotechnology, Hb encapsulation, absorption, bioconjugation, entrapment, attachment nanomaterials used prepare nanomaterial-related address these challenges pend application several biomedical therapeutic contexts. This review focuses on the progress this class fields hemorrhagic shock, ischemic stroke, cancer, wound healing, speculates future research directions. The expected lead significant breakthroughs substitutes, enabling widespread use treatment clinical Graphical

Language: Английский

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Negative-pressure wound therapy compared with advanced moist wound therapy: A comparative study on healing efficacy in diabetic foot ulcers

Surgery, Journal Year: 2025, Volume and Issue: 180, P. 109098 - 109098

Published: Jan. 9, 2025

Language: Английский

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Remote assessment and monitoring with advanced wound therapy to optimise clinical outcomes, access and resources

Journal of Wound Care, Journal Year: 2024, Volume and Issue: 33(2), P. 90 - 101

Published: Feb. 2, 2024

Objective: Patients in rural communities may have limited access to wound care; however, this be mitigated by using a shared care approach. This study assessed the impact of remote assessment and monitoring tool combination with adjunctive continuous topical oxygen therapy (cTOT) patients diabetes hard-to-heal wounds. Method: wounds (defined as no visible improvement previous four weeks) were enrolled 12-week pilot validate approach an Advanced Digital Wound Care Platform-telehealth (ADWCPt) system (eKare Inc., US) coupled cTOT. Patient assessments reviewed clinician either remotely, via telehealth calls, or at clinic, number face-to-face clinic visits was recorded. health status scores captured before after study, along feedback on usability platform cTOT device. Results: The all eight studied reduced size over 12 weeks (mean percentage area reduction 92.0%), two completely re-epithelialised. Another almost healed (99.2% reduction). Clinical interactions consisted self-assessments (n=80, 50.0%), video (n=27, 16.9%), (n=53, 33.1%). Operational efficiencies encompassed 54.0% increase clinical interactions, whereas time 25.8%. Health improved across device favourable. Conclusion: A model ADWCPt innovative saved resources, improving patient engagement, marked healing trajectory.

Language: Английский

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Systematik der Sauerstoffbehandlung in der Wundbehandlung

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 331 - 339

Published: Jan. 1, 2024

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The role of continuous topical oxygen therapy as an adjunctive treatment in non-healing chronic wounds: a South African perspective

Wound healing, Journal Year: 2024, Volume and Issue: 17(1), P. 15 - 21

Published: June 1, 2024

Language: Английский

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Impact of continuous topical oxygen therapy on biofilm gene expression in a porcine tissue model

Journal of Wound Care, Journal Year: 2024, Volume and Issue: 33(9), P. 702 - 707

Published: Sept. 2, 2024

Objective: The effect of continuous topical oxygen therapy (cTOT) on Pseudomonas aeruginosa biofilm gene transcription profiles following inoculation onto porcine skin, using a customised molecular assay was determined. Method: Sterilised skin explants were inoculated with in triplicate: 0 hours as negative control; 24 cTOT device on; off. delivery system the applied to tissue and covered semi-occlusive dressing. All samples incubated at 37±2°C for hours, control recovered immediately. Planktonic suspensions biopsy taken hours. Samples processed quantifiably assessed specific reverse transcription-quantitative polymerase chain reaction assays panel eight genes (16S, pelA, pslA, rsaL, pcrV, pscQ, acpP, cbrA) associated formation, quorum sensing, protein secretion/translocation metabolism. Results: Transcriptional upregulation pcrV responsible intracellular adhesion, needletip production type-3 secretion systems fatty acid synthesis during proliferation, respectively, observed when switched compared Data suggest increased metabolic activity within bacterial cells treatment. Conclusion: is an adjunctive that supports faster healing pain reduction non-healing hypoxic wounds. Oxygen has previously been shown increase susceptibility biofilms antibiotics through enhancing Observed expression changes highlighted impact biofilms, potentially influencing antimicrobial treatment success Further vitro clinical investigations are warranted.

Language: Английский

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Selected possibilities of physical medicine versus cancer diseases

Polski Merkuriusz Lekarski, Journal Year: 2024, Volume and Issue: 52(5), P. 598 - 603

Published: Jan. 1, 2024

Aims: This review aims to synthesize the latest literature on physical treatments for wounds, focusing use of ozone therapy, topical oxygen pulsed electromagnetic field and red light therapy in oncology patients. It evaluates indications, benefits, contraindications these therapies, especially concerning cancer. Materials Methods: A search was conducted publicly available online databases, covering publications English Polish from 2010 2024. The inclusion criteria comprised clinical trials, systematic reviews, meta-analyses, articles wounds selection process involved pre-selection, title abstract review, full-text ensure compliance with criteria. Data were analyzed identify mechanisms action, therapeutic efficacy, potential risks associated therapies Ozone showed reducing bacterial load tumor hypoxia, enhancing chemotherapy efficacy. Topical effective chronic careful application near sites. Pulsed demonstrated promising anticancer effects, inducing apoptosis cancer cells. Red while beneficial managing side effects treatments, contraindicated areas active tumors due risk stimulating cell proliferation. Conclusions: Physical offer benefits wound management but require consideration Personalized evaluation further research are essential establish safe protocols patients, maximizing minimizing risks.

Language: Английский

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