Cardiovascular toxicities associated with chimeric antigen receptor T-cell therapy DOI Creative Commons
Jiahui Liu, K Liu, Xiang Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a groundbreaking immunotherapeutic approach, particularly for oncohematological patients who are refractory to conventional treatments. As clinical trials expand the applications of CAR beyond hematologic malignancies, critical understanding its associated toxicities, cardiovascular complications, becomes imperative. This review synthesizes current literature on interplay between cytokine release syndrome (CRS) and cardiotoxicity related therapy, emphasizing potential severity these adverse events. While significant progress been made in managing CRS, cardiac manifestations-ranging from mild events life-threatening complications-remain underreported pivotal studies. We explore incidence nature real-world trial settings, identify risk factors contributing events, propose guidelines pre-therapy evaluations, post-infusion monitoring, management strategies. By highlighting urgent need heightened awareness proactive care, this aims enhance patient safety optimize outcomes evolving landscape therapy.

Language: Английский

Bridging Cancer and Cardiovascular Health: A Comprehensive Review of Cardiotoxicity in Modern Oncology DOI Creative Commons

Anjali Rajpoot,

Veena Sharma

Heart and Mind, Journal Year: 2025, Volume and Issue: 9(2), P. 115 - 135

Published: March 1, 2025

Abstract As survival rates for cancer patients improve due to advancements in treatment modalities, there is an increasing prevalence of cardiovascular complications, necessitating a comprehensive understanding this intersection. This review aims elucidate the intricate relationship between and disease, highlighting growing concern toxicity associated with therapies. It explores various treatments, including chemotherapy, targeted therapies, radiation, their risks, such as heart failure ischemic disease. In addition, it discusses importance proactive risk assessments ongoing monitoring mitigate adverse outcomes. Strategies prevention management, lifestyle modifications pharmacologic interventions, are also examined support health survivors. Unlike previous reviews, work integrates insights from multidisciplinary collaborations, emphasizing underexplored mechanisms role innovative tools. highlights emerging therapeutic strategies tailored these providing forward-looking perspective critical area research. The need collaborative method that includes oncologists, cardiologists, primary care providers emphasized ensure integrated addresses both health. serves resource healthcare professionals seeking long-term outcomes survivors by recognizing managing risks.

Language: Английский

Citations

0
Cardiovascular toxicities associated with chimeric antigen receptor T-cell therapy DOI Creative Commons
Jiahui Liu, K Liu, Xiang Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a groundbreaking immunotherapeutic approach, particularly for oncohematological patients who are refractory to conventional treatments. As clinical trials expand the applications of CAR beyond hematologic malignancies, critical understanding its associated toxicities, cardiovascular complications, becomes imperative. This review synthesizes current literature on interplay between cytokine release syndrome (CRS) and cardiotoxicity related therapy, emphasizing potential severity these adverse events. While significant progress been made in managing CRS, cardiac manifestations-ranging from mild events life-threatening complications-remain underreported pivotal studies. We explore incidence nature real-world trial settings, identify risk factors contributing events, propose guidelines pre-therapy evaluations, post-infusion monitoring, management strategies. By highlighting urgent need heightened awareness proactive care, this aims enhance patient safety optimize outcomes evolving landscape therapy.

Language: Английский

Citations

0