A brief molecular insight of COVID-19: epidemiology, clinical manifestation, molecular mechanism, cellular tropism and immuno-pathogenesis

Molecular and Cellular Biochemistry, Journal Year: 2021, Volume and Issue: 476(11), P. 3987 - 4002

Published: June 30, 2021

In December 2019, the emergence and expansion of novel infectious respiratory virus SARS-CoV-2 originated from Wuhan, China caused an unprecedented threat to public health became a global pandemic. is enveloped, positive sense single stranded RNA belonging genera betacoronavirus, Coronaviridae family. The viral genome sequencing studies revealed 75–80% similarity with SARS-CoV. mainly affects lower system may progress pneumonia Acute Respiratory Distress Syndrome (ARDS). Apart life-threatening situations burden on healthcare system, COVID-19 pandemic has imposed several challenges worldwide economics livelihood. pathogen highly virulent, rapidly mutating tendency cross species boundaries such as bats humans through evolution natural selection intermediate host. this review we tried summarize overall picture including origin/ emergence, epidemiology, pathogenesis, organization, comparative analysis other CoVs, infection replication mechanism along cellular tropism immunopathogenesis which will provide brief panoramic view about disease.

Language: Английский

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Impact of nonalcoholic fatty liver disease on clinical outcomes in patients with COVID-19 among persons living with HIV: A multicenter research network study

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(5), P. 673 - 679

Published: Feb. 13, 2023

People living with human immunodeficiency virus (PLWH) are at an increased risk of nonalcoholic fatty liver disease (NAFLD) but how these patients react to COVID-19 infection is unclear. We examined the clinical characteristics and outcomes without among people diagnosed COVID-19.

Language: Английский

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Academic self-efficacy as a protective factor for the mental health of university students during the COVID-19 pandemic

Interacciones Revista de Avances en Psicología, Journal Year: 2022, Volume and Issue: unknown, P. e289 - e289

Published: Dec. 28, 2022

Background: University students are vulnerable to developing mental health problems due constant exposure academic demands. A situation that has been exacerbated by the COVID-19 pandemic and observed in several recent studies. Therefore, current practices require further research identification of potentially protective factors for health. Objective: This study aimed analyze self-efficacy as a factor against depression, anxiety, stress university students. Methods: cross-sectional design was used with 3525 from Lima, Peru. The prevalence measured using DASS-21. Academic EPAESA defined predictor three conditions. Structural equation modeling test model, together multigroup analysis gender working status. Results: One-third sample had severe extremely symptoms stress. moderately statistically significant Relationships were invariant Conclusions: Self-efficacy can be considered Interventions promote may effective reducing findings discussed studies on topic.

Language: Английский

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Pharmaconutrition strategy to resolve SARS-CoV-2-induced inflammatory cytokine storm in non-alcoholic fatty liver disease: Omega-3 long-chain polyunsaturated fatty acids

World Journal of Clinical Cases, Journal Year: 2021, Volume and Issue: 9(31), P. 9333 - 9349

Published: Oct. 29, 2021

Inflammation is one of the primary factors associated with causation and/or progression several lifestyle disorders, including obesity, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD).NAFLD a spectrum starts simple steatosis, progresses to steatohepatitis, then advances fibrosis, cirrhosis finally, hepatocellular carcinoma, due perpetual cycles insults caused by inflammation other cellular stress.Emerging evidence has documented that patients NAFLD have severe coronavirus 2019 (COVID-19), COVID-19 higher injury mortality.Although exact cause or mechanism not known, inflammatory cytokine storm characteristic feature acute respiratory syndrome (SARS-CoV-2) infection known be mortality among patients.Therefore, pandemic seems major concern in patients, who contracted SARS-CoV-2 develop COVID-19.This evident at any stage spectrum, as may aggravate severity NAFLD.Thus, there need for resolution these patients.A large body demonstrated efficacy omega-3 long-chain polyunsaturated acids (ω-3 LCPUFA) conditions, their anti-inflammatory, immunomodulatory anti-viral properties.Therefore, intervention ω-3 LCPUFA, an effective pharmaconutrient along standard treatment useful management pre-existing conditions resolving thereby attenuating its progression.Although are challenges implementation, optimistically they can circumvented

Language: Английский

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Factors Associated with Severe COVID-19 in an Epidemic Treatment Center at Dakar

Journal of Infectious Diseases and Epidemiology, Journal Year: 2021, Volume and Issue: 7(4)

Published: April 30, 2021

Coronavirus infectious disease 2019 (COVID-19) pandemic is a global public health issue due to new coronavirus called severe acute respiratory syndrome virus 2 (SARS-Cov-2). It very contagious with often benign symptoms. However, some patients present clinical signs and are more at risk die. The aim of this study was assess the factors associated COVID-19 in an Epidemic Treatment Center (ETC) Dakar, Senegal.

Language: Английский

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