Exploration of the Potential and Mechanisms of Diabetic Cognitive Disorder Modulation by Daehwangmokdanpi-tang through a Network Pharmacological Approach DOI Open Access
Yebin Lim, Bitna Kweon,

Dong-Uk Kim

et al.

Journal of Korean Medicine, Journal Year: 2024, Volume and Issue: 45(2), P. 23 - 40

Published: June 1, 2024

Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds DHMDPT their target genes were obtained from OASIS PubChem databases. These putative compared with known targets DCD identify correlations. Using Cytoscape 3.10.2, was constructed highlight key genes. To further elucidate mechanisms, functional enrichment analysis performed using Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Finally, CB-DOCK used assess binding affinities confirm interactions.Results: results showed that total 27 439 related identified DHMDPT. Among these, 373 interacted gene set, indicating close relationship between DCD. Through GO KEGG pathways, ‘Regulation Apoptotic Process’, ‘Cytokine-Mediated signaling pathway’, ‘AGE-RAGE pathway complications’ as pathways 18 on Additionally, molecular docking six most highly associated active compounds.Conclusions: approach, which included docking, found be relevant could serve foundation for research enhancement

Language: Английский

Exploration of the Potential and Mechanisms of Diabetic Cognitive Disorder Modulation by Daehwangmokdanpi-tang through a Network Pharmacological Approach DOI Open Access
Yebin Lim, Bitna Kweon,

Dong-Uk Kim

et al.

Journal of Korean Medicine, Journal Year: 2024, Volume and Issue: 45(2), P. 23 - 40

Published: June 1, 2024

Objectives: This study utilized a network pharmacology approach to investigate the potential therapeutic effects and underlying mechanisms of Daehwangmokdanpi-tang (DHMDPT) in diabetic cognitive disorder (DCD).Methods: The compounds DHMDPT their target genes were obtained from OASIS PubChem databases. These putative compared with known targets DCD identify correlations. Using Cytoscape 3.10.2, was constructed highlight key genes. To further elucidate mechanisms, functional enrichment analysis performed using Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Finally, CB-DOCK used assess binding affinities confirm interactions.Results: results showed that total 27 439 related identified DHMDPT. Among these, 373 interacted gene set, indicating close relationship between DCD. Through GO KEGG pathways, ‘Regulation Apoptotic Process’, ‘Cytokine-Mediated signaling pathway’, ‘AGE-RAGE pathway complications’ as pathways 18 on Additionally, molecular docking six most highly associated active compounds.Conclusions: approach, which included docking, found be relevant could serve foundation for research enhancement

Language: Английский

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