A 0.57 mm2 Platform with 70.7% Efficient 4 mA 3.2 V Charge Pump and a Current-Input Ramp ADC for Implantable Optical Sensing of Tumors DOI

Md. Shahrul Islam,

Zephan M. Enciso,

Sunghoon Rho

et al.

2022 IEEE Biomedical Circuits and Systems Conference (BioCAS), Journal Year: 2023, Volume and Issue: unknown, P. 1 - 5

Published: Oct. 19, 2023

Continuous and real-time in vivo monitoring of solid tumors using implanted sensors would be transformative for precision health cancer research treatment. Optical techniques such as spectroscopy offer a path towards realizing treatments, but require additional miniaturization efforts. To address this need, we have designed prototyped an integrated circuit (IC) implantable in-vivo optical sensing tumors. Our prototype, fabricated 65nm CMOS technology, occupies 0.57mm 2 active area comprises high-efficiency cross-coupled charge pump two current-input ramp analog-to-digital converters (ADCs). The pump, with peak efficiency 70.7%, delivers 12.8 mW to power the off-chip light sources necessary spectroscopy. We validate our approach through measurements on tissue simulating phantom demonstrate prototypes suitability sensing.

Language: Английский

Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury DOI Creative Commons
Austen T. Lefebvre, Nicole Steiner,

Carissa L. Rodriguez

et al.

Neurotherapeutics, Journal Year: 2025, Volume and Issue: unknown, P. e00520 - e00520

Published: Jan. 1, 2025

Language: Английский

Citations

1
Neural Plasticity Changes Induced by Motor Robotic Rehabilitation in Stroke Patients: The Contribution of Functional Neuroimaging DOI Creative Commons
Lilla Bonanno, Antonio Cannuli, Loris Pignolo

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(8), P. 990 - 990

Published: Aug. 21, 2023

Robotic rehabilitation is one of the most advanced treatments helping people with stroke to faster recovery from motor deficits. The clinical impact this type treatment has been widely defined and established using scales. neurofunctional indicators following conventional have already identified by previous meta-analytic investigations. However, a clear definition neural correlates associated robotic neurorehabilitation never performed. This systematic review assesses (fMRI, fNIRS) cutting-edge therapies in enhancing populations accordance PRISMA standards. A total 7, initial yield 150 articles, included review. Lessons these studies suggest that plasticity within ipsilateral primary cortex, contralateral sensorimotor premotor cortices are more sensitive compensation strategies reflecting upper lower limbs’ despite high heterogeneity devices, status, neuroimaging procedures. Unfortunately, paucity RCT prevents us understanding neurobiological differences induced devices respect traditional approaches. Despite technology dating early 1990s, there need translate functional markers settings since they provide unique opportunity examine, in-depth, brain changes rehabilitation.

Language: Английский

Citations

15
Influence of Tissue Curvature on the Absolute Quantification in Frequency-Domain Diffuse Optical Spectroscopy DOI Open Access
Giovani Grisotti Martins, Rodrigo M. Forti, Rickson C. Mesquita

et al.

Spectroscopy Journal, Journal Year: 2025, Volume and Issue: 3(2), P. 14 - 14

Published: April 13, 2025

Accurate estimation of optical properties and hemodynamic parameters is critical for advancing frequency-domain diffuse spectroscopy (FD-DOS) techniques in clinical neuroscience. However, conventional FD-DOS models often assume planar air–tissue interfaces, introducing errors anatomically curved regions such as the forehead or infant heads. This study evaluates impact incorporating tissue curvature into forward analysis. Using simulations phantoms, we demonstrate that reduce absorption coefficient from 20% to less than 10% high-curvature scenarios. Within curvatures tested, even minor mismatches resulted significantly lower those observed approximations (p < 0.001). In low-curvature regions, yielded comparable (<5% both cases). When applied human data, our proposed model increased hemoglobin concentration estimates by 10–15% compared standard semi-infinite models, closer physiological expectations. Overall, these results quantitatively accounting improves accuracy property estimation. We propose a numerical framework achieves this fast reliable manner, robust tool research applications complex regions.

Language: Английский

Citations

0
Frequency domain broadband short-wave infrared spectroscopy for measurement of tissue optical properties from 685 to 1300 nm DOI Creative Commons

D. SUCIU,

Thao Pham,

Lina Lin Wei

et al.

Journal of Biomedical Optics, Journal Year: 2025, Volume and Issue: 30(04)

Published: April 25, 2025

Extending frequency domain diffuse optical spectroscopy (FD-DOS) into the short-wave infrared (SWIR) region has potential to improve measurements of key biological tissue chromophores such as water and lipids, given their higher absorption in SWIR compared with near-infrared wavelengths. Few studies have explored FD-DOS range. We present first demonstration a broadband (FD-Bb-SWIRS) system measure properties from 685 1300 nm. A custom hybrid was developed, combining discrete 980 nm continuous wave 900 This setup provided absolute ( μa ) spectra Validation performed using mineral oil-based solid phantoms, deuterium oxide D2O liquid desiccating porcine tissue. The FD-Bb-SWIRS sensitive changes varying concentrations absorbers phantoms. Ex vivo indicated differences content across different samples during baseline desiccation. is highly range enables precise quantification tissues. It represents significant step forward advancing SWIR-based for clinical applications.

Language: Английский

Citations

0
Aortic arch branch-prioritized reconstruction for type A aortic dissection surgery DOI Creative Commons
Jianfeng Gao,

Jie Yan,

Yanyu Duan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 10

Published: Jan. 23, 2024

Background Acute Stanford type A aortic dissection (STAAD) is a fatal condition requiring urgent surgical intervention. Owing to the complexity of process, various complications, such as neurological disorders, are common. In this study, we prioritized reconstruction arch branches during surgery and investigated association between prioritizing postoperative outcomes patients with STAAD. Methods Ninety-seven were included in observational study underwent total replacement frozen elephant trunk technique January 2018 June 2021. Of these, 35 branch-priority technique, 62 classic technique. By analyzing perioperative outcomes, compared differences two techniques. Results The branch priority group had significantly shorter cardiopulmonary bypass ventilator times earlier wake-up than group. Additionally, ICU stay time was shorter, significant decrease complications 24 h drainage Conclusion can effectively provide better brain protection, resulting awakening after surgery, reduced ventilation decreased hospitalization time. Therefore, it recommended for use surgeries.

Language: Английский

Citations

1
Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy DOI Creative Commons
Thao Pham,

Lina Lin Wei,

Darren Roblyer

et al.

Biomedical Optics Express, Journal Year: 2024, Volume and Issue: 15(8), P. 4963 - 4963

Published: July 22, 2024

Frequency-domain diffuse optical spectroscopy (FD-DOS) is a powerful non-invasive technique for assessing tissue properties, with applications ranging from basic research to clinical diagnosis. In this study, we introduce and validate novel approach termed the cross-wavelength calibrating (CWC) method within framework of TrackDOSI, real-time FD-DOS imaging system characterization. The CWC aims mitigate effects changing coupling motion artifacts encountered during probe scanning, thus enhancing accuracy reliability property measurements. Notably, also allows simpler geometry fewer sources than traditional self-calibrating (SC) methods, reducing instrumental complexity cost while maintaining robustness in estimating properties. We first on solid silicone phantoms, demonstrating strong agreement gold standard SC an error -10% 1% absorption reduced scattering coefficients, respectively. Furthermore, experiments phantom human reveal approach's ability suppress variations, thereby improving measurement repeatability, signal fidelity, artifact correction dynamic scenarios. Our findings underscore potential enhance utility DOSI techniques by enabling

Language: Английский

Citations

1
Modified Beer-Lambert algorithm to measure pulsatile blood flow, critical closing pressure, and intracranial hypertension DOI Creative Commons
Wesley B. Baker, Rodrigo M. Forti, Pascal Heye

et al.

Biomedical Optics Express, Journal Year: 2024, Volume and Issue: 15(9), P. 5511 - 5511

Published: Aug. 13, 2024

We introduce a frequency-domain modified Beer-Lambert algorithm for diffuse correlation spectroscopy to non-invasively measure flow pulsatility and thus critical closing pressure (CrCP). Using the same optical measurements, CrCP was obtained with new traditional nonlinear diffusion fitting. Results were compared invasive determination of intracranial (ICP) in piglets (n = 18). The better predicted ICP elevations; area under curve (AUC) from logistic regression analysis 0.85 ≥ 20 mmHg. corresponding AUC 0.60. Improved diagnostic performance likely results filtering extra-cerebral tissue contamination measurement noise.

Language: Английский

Citations

1
Comparing NIRS and Pulse Oximetry for Cerebral Oxygen Saturation During Hypoxia Testing DOI Creative Commons
Vasilios Alevizakos, A. Werner,

L. Schiller

et al.

Medical Sciences, Journal Year: 2024, Volume and Issue: 12(4), P. 59 - 59

Published: Oct. 24, 2024

This study evaluates the suitability of cerebral oximetry using near-infrared spectroscopy (NIRS) compared to traditional pulse (SpO2) for measuring oxygen saturation during hypoxia testing, aiming enhance safety flight operations and training.

Language: Английский

Citations

1
Replacement of raw materials in the formulation of industrial products based on near-infrared spectroscopy and particle swarm optimization DOI
Zhongda Zeng, Hui Lin Jiang,

Liliang Wen

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: 201, P. 110704 - 110704

Published: May 9, 2024

Language: Английский

Citations

0
Assessing Image Reproducibility in Free-Form Raster Scan fdNIRS Imaging DOI

Gerardo Silva-Oelker,

Roy A. Stillwell,

Eric W. Sheeder

et al.

Published: Jan. 1, 2024

This study develops reliable and reproducible imaging practices using a free-form raster scan based on fdNIRS. We propose investigate the reproducibility of images, finding minimum correlation coefficient 0.789 between scans.

Language: Английский

Citations

0