Nature, Journal Year: 2024, Volume and Issue: 630(8017), P. 571 - 573
Published: June 5, 2024
Language: Английский
Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(4), P. 424 - 436
Published: April 1, 2021
Language: Английский
Citations
185
Trends in Biochemical Sciences, Journal Year: 2021, Volume and Issue: 46(10), P. 790 - 804
Published: May 27, 2021
Language: Английский
Citations
150
Nature Cell Biology, Journal Year: 2022, Volume and Issue: 24(4), P. 415 - 423
Published: April 1, 2022
Language: Английский
Citations
130
Nature, Journal Year: 2024, Volume and Issue: 630(8017), P. 720 - 727
Published: June 5, 2024
Abstract Spermatozoa harbour a complex and environment-sensitive pool of small non-coding RNAs (sncRNAs) 1 , which influences offspring development adult phenotypes 1–7 . Whether spermatozoa in the epididymis are directly susceptible to environmental cues is not fully understood 8 Here we used two distinct paradigms preconception acute high-fat diet dissect epididymal versus testicular contributions sperm sncRNA health. We show that spermatozoa, but developing germ cells, sensitive environment identify mitochondrial tRNAs (mt-tRNAs) their fragments (mt-tsRNAs) as sperm-borne factors. In humans, mt-tsRNAs correlate with body mass index, paternal overweight at conception doubles obesity risk compromises metabolic Sperm sequencing mice mutant for genes involved function, phenotyping wild-type offspring, suggest upregulation downstream dysfunction. Single-embryo transcriptomics genetically hybrid two-cell embryos demonstrated sperm-to-oocyte transfer mt-tRNAs fertilization suggested involvement control early-embryo transcription. Our study supports importance health metabolism, shows diet-induced demonstrates, physiological setting, father-to-offspring fertilization.
Language: Английский
Citations
58
Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(5), P. 359 - 378
Published: Jan. 5, 2024
Language: Английский
Citations
25
Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216701 - 216701
Published: Feb. 16, 2024
A new class of noncoding RNAs, tsRNAs are not only abundant in humans but also have high tissue specificity. Recently, an increasing number studies explored the correlations between and tumors, showing that can affect biological behaviors tumor cells, such as proliferation, apoptosis metastasis, by modulating protein translation, RNA transcription or posttranscriptional regulation. In addition, widely distributed stably expressed, which endows them with broad application prospects diagnosing predicting prognosis they expected to become biomarkers. However, notably, current research on still faces problems need be solved. this review, we describe characteristics well their unique features functions tumors. Moreover, discuss potential opportunities challenges clinical applications tsRNAs.
Language: Английский
Citations
22
Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 16, 2025
Recent studies support the influence of paternal lifestyle and diet before conception on health offspring via epigenetic inheritance through sperm DNA methylation, histone modification, small non-coding RNA (sncRNA) expression regulation. Smoking may induce hypermethylation in genes related to anti-oxidation insulin resistance. Paternal obesity are associated with greater risks metabolic dysfunction alterations sperm. Metabolic changes, such as high blood glucose levels increased body weight, commonly observed fathers subjected chronic stress, addition an enhanced risk depressive-like behaviour sensitivity stress both F0 F1 generations. methylation is correlated quality ability fertilise oocytes, possibly a differentially regulated MAKP81IP3 signalling pathway. exposure toxic endocrine-disrupting chemicals (EDCs) also linked transgenerational transmission predisposition disease, infertility, testicular disorders, obesity, polycystic ovarian syndrome (PCOS) females changes during gametogenesis. As success assisted reproductive technology (ART) affected by diet, BMI, alcohol consumption, its outcomes could be improved modifying factors that dependent male choices environmental factors. This review discusses importance signatures sperm—including retention, sncRNA—for functionality, early embryo development, health. We discuss mechanisms which (obesity, smoking, EDCs, stress) impact epigenome.
Language: Английский
Citations
2
Obesity Reviews, Journal Year: 2020, Volume and Issue: 22(1)
Published: July 23, 2020
Summary The present updated systematic review and meta‐analysis aims to summarize the evidence from published studies with low risk for any important bias (based on methodological quality assessment) investigating potential associations of adiposity sperm reproductive hormones. We conducted a search literature in MEDLINE‐PubMed EMBASE through June 2019. Based criteria our review, 169 eligible publications were used data abstraction. Finally, 60 articles included qualitative analysis 28 quantitative analysis. Our results indicated that overweight and/or obesity associated semen parameters (i.e., volume, count concentration, vitality normal morphology) some specific hormones (e.g., inhibin B, total testosterone sex hormone‐binding globulin). Overweight also positively high estradiol concentrations. Meta‐analysis categories lower vitality, motility morphology), underweight category was likewise morphology. In conclusion, suggest maintaining healthy body weight is increasing potentially male fertility.
Language: Английский
Citations
106
Science Advances, Journal Year: 2021, Volume and Issue: 7(7)
Published: Feb. 10, 2021
Depressive phenotypes induced by paternal stress can be transferred from one generation to the next via small RNAs in sperm.
Language: Английский
Citations
94
Nature Metabolism, Journal Year: 2020, Volume and Issue: 2(9), P. 858 - 872
Published: Sept. 14, 2020
Language: Английский
Citations
92