Frontiers in Pharmacology,
Journal Year:
2020,
Volume and Issue:
11
Published: Sept. 17, 2020
Transfer
RNAs
(tRNAs)
are
abundantly
expressed,
small
non-coding
that
have
long
been
recognized
as
essential
components
of
the
protein
translation
machinery.
The
tRNA-derived
(tsRNAs),
including
tRNA
halves
(tiRNAs),
and
fragments
(tRFs),
were
unexpectedly
discovered
implicated
in
a
variety
important
biological
functions
such
cell
proliferation,
differentiation,
apoptosis.
Mechanistically,
tsRNAs
regulate
mRNA
destabilization
translation,
well
retro-element
reverse
transcriptional
post-transcriptional
processes.
Emerging
evidence
has
shown
expressed
heart,
their
expression
can
be
induced
by
pathological
stress,
hypertrophy.
Interestingly,
cardiac
pathophysiological
conditions,
oxidative
aging,
metabolic
disorders
viewed
inducers
tsRNA
biogenesis,
which
further
highlights
potential
involvement
these
conditions.
There
is
increasing
enthusiasm
for
investigating
molecular
heart
role
cardiovascular
disease.
It
anticipated
this
new
class
will
offer
perspectives
understanding
disease
mechanisms
may
provide
therapeutic
targets
to
treat
Nature,
Journal Year:
2024,
Volume and Issue:
630(8017), P. 720 - 727
Published: June 5, 2024
Abstract
Spermatozoa
harbour
a
complex
and
environment-sensitive
pool
of
small
non-coding
RNAs
(sncRNAs)
1
,
which
influences
offspring
development
adult
phenotypes
1–7
.
Whether
spermatozoa
in
the
epididymis
are
directly
susceptible
to
environmental
cues
is
not
fully
understood
8
Here
we
used
two
distinct
paradigms
preconception
acute
high-fat
diet
dissect
epididymal
versus
testicular
contributions
sperm
sncRNA
health.
We
show
that
spermatozoa,
but
developing
germ
cells,
sensitive
environment
identify
mitochondrial
tRNAs
(mt-tRNAs)
their
fragments
(mt-tsRNAs)
as
sperm-borne
factors.
In
humans,
mt-tsRNAs
correlate
with
body
mass
index,
paternal
overweight
at
conception
doubles
obesity
risk
compromises
metabolic
Sperm
sequencing
mice
mutant
for
genes
involved
function,
phenotyping
wild-type
offspring,
suggest
upregulation
downstream
dysfunction.
Single-embryo
transcriptomics
genetically
hybrid
two-cell
embryos
demonstrated
sperm-to-oocyte
transfer
mt-tRNAs
fertilization
suggested
involvement
control
early-embryo
transcription.
Our
study
supports
importance
health
metabolism,
shows
diet-induced
demonstrates,
physiological
setting,
father-to-offspring
fertilization.
Cancer Letters,
Journal Year:
2024,
Volume and Issue:
587, P. 216701 - 216701
Published: Feb. 16, 2024
A
new
class
of
noncoding
RNAs,
tsRNAs
are
not
only
abundant
in
humans
but
also
have
high
tissue
specificity.
Recently,
an
increasing
number
studies
explored
the
correlations
between
and
tumors,
showing
that
can
affect
biological
behaviors
tumor
cells,
such
as
proliferation,
apoptosis
metastasis,
by
modulating
protein
translation,
RNA
transcription
or
posttranscriptional
regulation.
In
addition,
widely
distributed
stably
expressed,
which
endows
them
with
broad
application
prospects
diagnosing
predicting
prognosis
they
expected
to
become
biomarkers.
However,
notably,
current
research
on
still
faces
problems
need
be
solved.
this
review,
we
describe
characteristics
well
their
unique
features
functions
tumors.
Moreover,
discuss
potential
opportunities
challenges
clinical
applications
tsRNAs.
Clinical Epigenetics,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 16, 2025
Recent
studies
support
the
influence
of
paternal
lifestyle
and
diet
before
conception
on
health
offspring
via
epigenetic
inheritance
through
sperm
DNA
methylation,
histone
modification,
small
non-coding
RNA
(sncRNA)
expression
regulation.
Smoking
may
induce
hypermethylation
in
genes
related
to
anti-oxidation
insulin
resistance.
Paternal
obesity
are
associated
with
greater
risks
metabolic
dysfunction
alterations
sperm.
Metabolic
changes,
such
as
high
blood
glucose
levels
increased
body
weight,
commonly
observed
fathers
subjected
chronic
stress,
addition
an
enhanced
risk
depressive-like
behaviour
sensitivity
stress
both
F0
F1
generations.
methylation
is
correlated
quality
ability
fertilise
oocytes,
possibly
a
differentially
regulated
MAKP81IP3
signalling
pathway.
exposure
toxic
endocrine-disrupting
chemicals
(EDCs)
also
linked
transgenerational
transmission
predisposition
disease,
infertility,
testicular
disorders,
obesity,
polycystic
ovarian
syndrome
(PCOS)
females
changes
during
gametogenesis.
As
success
assisted
reproductive
technology
(ART)
affected
by
diet,
BMI,
alcohol
consumption,
its
outcomes
could
be
improved
modifying
factors
that
dependent
male
choices
environmental
factors.
This
review
discusses
importance
signatures
sperm—including
retention,
sncRNA—for
functionality,
early
embryo
development,
health.
We
discuss
mechanisms
which
(obesity,
smoking,
EDCs,
stress)
impact
epigenome.
Obesity Reviews,
Journal Year:
2020,
Volume and Issue:
22(1)
Published: July 23, 2020
Summary
The
present
updated
systematic
review
and
meta‐analysis
aims
to
summarize
the
evidence
from
published
studies
with
low
risk
for
any
important
bias
(based
on
methodological
quality
assessment)
investigating
potential
associations
of
adiposity
sperm
reproductive
hormones.
We
conducted
a
search
literature
in
MEDLINE‐PubMed
EMBASE
through
June
2019.
Based
criteria
our
review,
169
eligible
publications
were
used
data
abstraction.
Finally,
60
articles
included
qualitative
analysis
28
quantitative
analysis.
Our
results
indicated
that
overweight
and/or
obesity
associated
semen
parameters
(i.e.,
volume,
count
concentration,
vitality
normal
morphology)
some
specific
hormones
(e.g.,
inhibin
B,
total
testosterone
sex
hormone‐binding
globulin).
Overweight
also
positively
high
estradiol
concentrations.
Meta‐analysis
categories
lower
vitality,
motility
morphology),
underweight
category
was
likewise
morphology.
In
conclusion,
suggest
maintaining
healthy
body
weight
is
increasing
potentially
male
fertility.
