Targeted Delivery Methods for Anticancer Drugs

Cancers, Journal Year: 2022, Volume and Issue: 14(3), P. 622 - 622

Published: Jan. 26, 2022

Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs increase their effectiveness selectivity. Besides traditional liposomal micellar formulations, various nanocarrier recently become focus developmental interest. This review discusses preparation targeting techniques as well properties several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, magnetic-nanoparticle-based systems. Approaches for targeted drug release under a range stimuli are also discussed.

Language: Английский

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Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges

Frontiers in Medical Technology, Journal Year: 2023, Volume and Issue: 4

Published: Jan. 6, 2023

Cancer is a life-threatening disease, resulting in nearly 10 million deaths worldwide. There are various causes of cancer, and the prognostic information varies each patient because unique molecular signatures human body. However, genetic heterogeneity occurs due to different cancer types changes neoplasms, which complicates diagnosis treatment. Targeted drug delivery considered pivotal contributor precision medicine for treatments as this method helps deliver medication patients by systematically increasing concentration on targeted body parts. In such cases, nanoparticle-mediated integration artificial intelligence (AI) can help bridge gap enhance localized systems capable biomarker sensing. Diagnostic assays using nanoparticles (NPs) enable identification accumulating specific sites ensuring accurate planning. Integrating NPs targeting AI devise sophisticated that further classify understand complex disease patterns. Advanced algorithms also detection, predicting NP interactions drug, evaluating efficacy. Considering advantages convergence delivery, there has been significantly limited research focusing theme, with most being proposed discovery. Thus, study's primary objective highlight recent advances NPs, their impact personalized treatment plans patients. addition, focal point study how integrating AI, address some existing challenges conducting collective survey.

Language: Английский

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Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway

Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 49(9), P. 8907 - 8924

Published: March 28, 2022

Language: Английский

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The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance

Biology, Journal Year: 2023, Volume and Issue: 12(2), P. 204 - 204

Published: Jan. 28, 2023

Today’s research on the processes of carcinogenesis and vital activity tumor tissues implies more attention be paid to constituents microenvironment their interactions. These interactions between cells in can mediated via different types protein junctions. Connexins are one major contributors intercellular communication. They form gap junctions responsible for transfer ions, metabolites, peptides, miRNA, etc., neighboring as well stromal cells. Connexin hemichannels mediate purinergic signaling bidirectional molecular transport with extracellular environment. Additionally, connexins have been reported localize tumor-derived exosomes facilitate release cargo. A large body evidence that role cancer is multifaceted. The pro- or anti-tumorigenic properties determined by abundance, localization, functionality channel assembly non-channel functions. In this review, we summarized data contribution formation initiation progression.

Language: Английский

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The end of the genetic paradigm of cancer

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(3), P. e3003052 - e3003052

Published: March 18, 2025

Genome sequencing of cancer and normal tissues, alongside single-cell transcriptomics, continues to produce findings that challenge the idea is a ‘genetic disease’, as posited by somatic mutation theory (SMT). In this prevailing paradigm, tumorigenesis caused cancer-driving mutations clonal expansion. However, results from tumor sequencing, motivated genetic paradigm itself, create apparent ‘paradoxes’ are not conducive pure SMT. But beyond causation, new lend credence old ideas organismal biology. To resolve inconsistencies between biological reality, we must complement deep with thinking: embrace formal historicity entities, (re)consider non-genetic plasticity cells tissues. Essay, discuss concepts cell state dynamics tissue fields emerge collective action genes in their morphogenetic context, respectively, how they help explain data context

Language: Английский

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Reconciling Non-Genetic Plasticity with Somatic Evolution in Cancer

Trends in cancer, Journal Year: 2021, Volume and Issue: 7(4), P. 309 - 322

Published: Feb. 1, 2021

Language: Английский

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Domains and Major Transitions of Social Evolution

Oxford University Press eBooks, Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 3, 2022

Abstract Evolutionary change is usually incremental and continuous, but some increases in organizational complexity have been radical divisive. biologists, who refer to such events as “major transitions,” not always appreciated that these advances were novel forms of pairwise commitment subjugated previously independent agents. Inclusive fitness theory convincingly explains cooperation conflict societies animals free-living cells, deserve its eminent status it should also capture how major transitions originated: from prokaryote cells eukaryote via differentiated multicellularity, colonies with specialized queen worker castes. As yet, no attempt has made apply inclusive principles the origins events. Domains Major Transitions Social Evolution develops idea evolutionary involved new levels informational closure moved beyond looser partnerships. Early neo-Darwinians understood this principle, later social gradient thinking obscured discontinuity life’s fundamental transitions. The author argues required maximal kinship simple ancestors—not reduction already elaborate societies. Reviewing more than a century literature, he makes testable predictions, proposing open closed organisms require very different explanations. It appears only human ancestors lived complex before our cultural transition occurred. We therefore impose trajectory own history on rest nature. This thought-provoking text suitable for graduate-level students taking courses biology, behavioral ecology, organismal developmental genetics, well professional researchers fields. will appeal broader, interdisciplinary audience, including sciences humanities. Jacobus J. Boomsma Professor Ecology at University Copenhagen.

Language: Английский

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Modeling Organogenesis from Biological First Principles

History, philosophy and theory of the life sciences, Journal Year: 2023, Volume and Issue: unknown, P. 263 - 283

Published: Nov. 10, 2023

Language: Английский

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Very small embryonic-like stem cells have the potential to win the three-front war on tissue damage, cancer, and aging

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 10

Published: Jan. 4, 2023

The concept of dedifferentiation and reprogramming mature somatic cells holds much promise for the three-front "war" against tissue damage, cancer, aging. It was hoped that human into induced pluripotent state, along with use embryonic stem cells, would transform regenerative medicine. However, despite global efforts, clinical applications remain a distant dream, due to associated factors such as genomic instability, tumorigenicity, immunogenicity, heterogeneity. Meanwhile, expression (pluripotent) markers in multiple cancers has baffled scientific community, it been suggested dedifferentiate "reprogram" state vivo initiate cancer. also aging can be reversed by partial vivo. better methods are needed; using vectors or Yamanaka vivo, example, is dangerous, many potential anti-aging therapies carry same risks those described above. present perspective examines endogenous, very small embryonic-like (VSELs). These naturally tissues; they routinely replace diseased ensure regeneration maintain life-long homeostasis, have ability differentiate adult counterparts. Recent evidence suggests selective expansion epigenetically altered VSELs their blocked differentiation. Furthermore, VSEL numbers directly linked lifespan studies long- short-lived transgenic mice, dysfunction found ovaries aged mice. To conclude, greater interest VSELs, address all three fronts this war, could "light at end tunnel."

Language: Английский

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A vision for safer food contact materials: Public health concerns as drivers for improved testing

Environment International, Journal Year: 2023, Volume and Issue: 180, P. 108161 - 108161

Published: Sept. 26, 2023

Food contact materials (FCMs) and food articles are ubiquitous in today's globalized system. Chemicals migrate from FCMs into foodstuffs, so called chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health hazardous FCCs because only individual substances used to make tested mostly for genotoxicity while endocrine disruption other hazard properties disregarded. Indeed, a known source of wide range chemicals, they likely contribute highly prevalent non-communicable diseases. can also include non-intentionally added (NIAS), which often unknown therefore subject risk assessment. To address these important shortcomings, we outline how the safety may be improved by (1) testing overall migrate, including (unknown) NIAS, finished articles, (2) expanding toxicological beyond multiple endpoints associated with diseases relevant human health. identify mechanistic testing, group chronic outcomes chemical exposure Six Clusters Disease (SCOD) propose that should their impacts on SCOD. Research focus developing robust, relevant, sensitive in-vitro assays based information linked SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics Toxicants. Implementing this vision will improve prevention exposures, FCMs.

Language: Английский

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