Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 215 - 226

Published: June 22, 2023

Language: Английский

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Sex differences in change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

Changing one's mind involves re-appraisals between past-costs versus future-value and may be altered in psychopathology. Long intergenic non-coding RNA LINC00473 medial prefrontal cortex (mPFC) can induce stress-resilience a sex-dependent manner, but its role cognition is unknown. We characterized decision-making behavior male female mice the neuroeconomic paradigm Restaurant Row following virus-mediated expression of mPFC. Mice foraged for food among varying temporal-costs subjective-value while on limited time-budget. Without affecting primary deliberative decisions, selectively influenced re-evaluative choices manner. This included changing how (i) cached value with passage time (ii) weighed prior mistakes, which underlie computational bases sensitivity to sunk costs regret. These findings suggest common function shared these processes reveal bridge molecular drivers psychological mechanisms underlying sex-specific proclivities negative rumination.

Language: Английский

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Neuroeconomically dissociable forms of mental accounting are altered in a mouse model of diabetes

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 21, 2025

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, especially mood yet the link between hyperglycemia and altered motivation has not been thoroughly explored. Here, we characterized value-based decision-making behavior a streptozocin-induced diabetic mouse model on Restaurant Row, naturalistic neuroeconomic foraging paradigm capable behaviorally capturing multiple decision systems known to depend dissociable neural circuits. Mice made self-paced choices daily limited time-budget, accepting or rejecting reward offers based cost (delays cued by tone pitch) subjective value (flavors), in closed-economy system tested across months. We found streptozocin-treated mice disproportionately undervalued less-preferred flavors inverted their meal-consumption patterns shifted toward more costly strategy overprioritizing high-value rewards. These behaviors were driven impairments processes, including ability deliberate when engaged conflict cache passage time as sunk costs. Surprisingly, diabetes-induced changes depended only type choice being made, but also salience reward-scarcity environment. findings suggest that complex relationships metabolic dysfunction valuation algorithms underlying unique cognitive heuristics sensitivity opportunity costs can disrupt distinct computational processes leading comorbid vulnerabilities. A approach characterize reveals alterations diabetes, shedding light interaction energy balance, heuristics.

Language: Английский

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Ketamine reverses stress-induced hypersensitivity to sunk costs

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

How mood interacts with information processing in the brain is thought to mediate maladaptive behaviors observed depressed individuals. However, neural mechanisms underlying impairments emotion-cognition interactions are poorly understood. This includes influencing balance between how past-sensitive vs. future-looking one during decision-making. Recent insights from field of neuroeconomics offer novel approaches study changes such valuation processes a manner that biologically tractable and readily translatable across species. We recently discovered rodents sensitive "sunk costs" - feature higher cognition previously be unique humans. The sunk costs bias describes phenomenon which an individual overvalues escalates commitment continuing ongoing endeavor, even if suboptimal, as function irrecoverable past (sunk) losses that, according classic economic theory, should ignored. In present study, mice were exposed chronic social defeat stress paradigm, well-established animal model used for depression. Mice then tested on our longitudinal neuroeconomic foraging task, Restaurant Row. found this severe stressor displayed increased sensitivity costs, without altering overall willingness wait. randomly assigned receive single intraperitoneal injection either saline or ketamine (20 mg/kg). stress-induced hypersensitivity was renormalized following dose ketamine. Interestingly, non-defeated mice, treatment completely abolished cost sensitivity, causing no longer value re-evaluation decisions who instead based choices solely future investment required obtain goal. These findings suggest antidepressant effects may mediated part through on-going decision-making, reducing its weight potential source cognitive dissonance could modulate behavior promoting more future-thinking behavior.

Language: Английский

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Research on User Behavior Based on Higher-Order Dependency Network

Entropy, Journal Year: 2023, Volume and Issue: 25(8), P. 1120 - 1120

Published: July 26, 2023

In the era of popularization Internet Things (IOT), analyzing people's daily life behavior through data collected by devices is an important method to mine potential requirements. The network means analyze relationship between behaviors, while mainstream first-order (FON) ignores high-order dependencies behaviors. A higher-order dependency (HON) can more accurately requirements considering dependencies. Firstly, our work adopts indoor sequences obtained video detection, extracts rules from sequences, and rewires HON. Secondly, HON used for RandomWalk algorithm. On this basis, research on vital node identification community detection carried out. Finally, results behavioral datasets show that, compared with FONs, HONs significantly improve accuracy random walk, nodes, we find that a belong multiple communities. Our improves performance user analysis thus benefits mining requirements, which be personalized recommendations product improvements, eventually achieve higher commercial profits.

Language: Английский

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Diabetes alters neuroeconomically dissociable forms of mental accounting

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 4, 2024

Those with diabetes mellitus are at high-risk of developing psychiatric disorders, yet the link between hyperglycemia and alterations in motivated behavior has not been explored detail. We characterized value-based decision-making a streptozocin-induced diabetic mouse model on naturalistic neuroeconomic foraging paradigm called Restaurant Row. Mice made self-paced choices while limited time-budget accepting or rejecting reward offers as function cost (delays cued by tone-pitch) subjective value (flavors), tested daily closed-economy system across months. found streptozocin-treated mice disproportionately undervalued less-preferred flavors inverted their meal-consumption patterns shifted toward more costly strategy that overprioritized high-value rewards. discovered these behaviors were driven impairments multiple systems, including ability to deliberate when engaged conflict cache passage time form sunk costs. Surprisingly, diabetes-induced changes depended only type choice being but also salience reward-scarcity environment. These findings suggest complex relationships glycemic regulation dissociable valuation algorithms underlying unique cognitive heuristics sensitivity opportunity costs can disrupt fundamentally distinct computational processes could give rise vulnerabilities.

Language: Английский

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IUPHAR Editorial: Emerging Targets for the Treatment of Pain: Moving towards non-addicting therapeutics and New Preclinical Directions

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107339 - 107339

Published: Aug. 4, 2024

Language: Английский

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