Obstructive Sleep Apnea and Circadian Rhythms DOI Creative Commons
Aynur Aliyeva

kulak burun boğaz ve baş boyun cerrahisi dergisi, Journal Year: 2023, Volume and Issue: 31(3), P. 179 - 188

Published: Jan. 1, 2023

ABS TRACT Obstructive sleep apnea (OSA) is a disorder characterized by recurrent episodes of partial or complete obstruction the upper airway during sleep.Circadian rhythms are natural biological that follow 24-hour cycle and synchronized with external cues, primarily alternating patterns light darkness.The relationship between circadian complex multifaceted.Disruptions in can impact quality overall sleep-wake regulation.In case apnea, lead to disruptions normal pattern.Sleep fragmentation apnea-related factors, such as intermittent hypoxia oxidative stress, directly affect molecular cellular mechanisms underlying rhythms.Clinical basic research studies have provided further evidence rhythm OSA.These highlight importance clock regulating breathing, metabolism, hormone secretion, OSA on melatonin blood pressure, glucose propose it potential therapeutic target for associated metabolic disorders.Understanding important managing treating its comorbidities.This review paper explores systemic aspects rhythm, their OSA, implications disease development treatment literature highlights.

Language: Английский

Circadian Clock and Hypoxia DOI Open Access
Francesca Sartor, Borja Ferrero‐Bordera, Jeffrey A. Haspel

et al.

Circulation Research, Journal Year: 2024, Volume and Issue: 134(6), P. 618 - 634

Published: March 14, 2024

The timing of life on Earth is remarkable: between individuals the same species, a highly similar temporal pattern observed, with shared periods activity and inactivity each day. At individual level, this means that over course single day, person alternates two states. They are either upright, active, communicative or they lie down in state (un)consciousness called sleep where even characteristic neuronal signals brain shows distinctive properties. circadian clock governs both these time stamps-activity (apparent) inactivity-making them come go consistently at approximate This behavior thus represents meeting pervasive systems: metabolism. In article, we will describe what known about how anticipates daily changes oxygen usage, regulation may relate to normal physiology, hypoxia ischemia can result from pathologies such as myocardial infarction stroke.

Language: Английский

Citations

10
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research DOI Creative Commons
Shaunak Deota, Julie S. Pendergast, Ullas Kolthur‐Seetharam

et al.

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

1
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation DOI
Qiang Li, Zhengchao Xia, Yi Wu

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: 291(14), P. 3191 - 3210

Published: April 11, 2024

Adaptation to hypoxia has attracted much public interest because of its clinical significance. However, hypoxic adaptation in the body is complicated and difficult fully explore. To explore previously unknown conserved mechanisms key proteins involved different species, we first used a yeast model for mechanistic screening. Further multi-omics analyses multiple species including yeast, zebrafish mice revealed that glycerophospholipid metabolism was significantly with up-regulation lysophospholipid acyltransferase (ALE1) protein formation dipalmitoyl phosphatidylcholine [DPPC (16:0/16:0)], which saturated phosphatidylcholine. Importantly, mammalian homolog ALE1, lysophosphatidylcholine 1 (LPCAT1), enhanced DPPC levels at cell membrane exhibited same protective effect cells under conditions. supplementation effectively attenuated growth restriction, maintained integrity increased expression epidermal factor receptor conditions, but unsaturated did not. In agreement these findings, treatment could also repair injury intestinal mucosa mice. Taken together, ALE1/LPCAT1-mediated formation, pathway metabolism, crucial viability Moreover, found ALE1 glycolysis maintain sufficient survival conditions yeast. The present study offers novel approach understanding lipid provides new insights into treating hypoxia-related diseases.

Language: Английский

Citations

5
Circadian clock dysregulation: a potential mechanism of depression in obstructive sleep apnea patients DOI Creative Commons
Agata Gabryelska, Szymon Turkiewicz, Piotr Kaczmarski

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 7, 2024

Abstract Obstructive sleep apnea (OSA) is characterized by co-occurrence with affective disorders. Our study aims to investigate the association of circadian clock gene expressions, and presence severity depressive symptoms in OSA patients. The included 184 individuals, who underwent polysomnography (PSG) had their peripheral blood collected evening before morning after PSG. Patients were divided into two groups: (apnea-hypopnea index (AHI) > 5) control group (AHI < 5). RNA was extracted from leukocytes. Expression levels selected genes ( BMAL1 , CLOCK PER1 CRY1 NPAS2 NR1D1 ) assessed qRT-PCR. Questionnaire data (including Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Chronotype (CQ), Montgomery–Åsberg Depression Rating (MADRS)). expression all examined patients upregulated compared (except ). No differences observed between groups at either time point. Additionally, there a positive correlation (assessed MADRS) Finally, multivariable linear regression, ISI score B = 0.750, p 0.001), AM CQ 0.416, 0.007), 4.310, 0.042) found be predictive factors for greater depression Dysregulated linked symptom severity, suggesting disruption may underlie OSA.

Language: Английский

Citations

5
The association between obstructive sleep apnea and nocturnal enuresis in children: current advances and research trends DOI
Zhaokai Zhou, Zhan Wang, Peng Fu

et al.

World Journal of Urology, Journal Year: 2025, Volume and Issue: 43(1)

Published: March 10, 2025

Language: Английский

Citations

0
Potential bidirectional communication between the liver and the central circadian clock in MASLD DOI Creative Commons
Frédéric Gachon, Elisabetta Bugianesi, Gabriele Castelnuovo

et al.

npj Metabolic Health and Disease, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 9, 2025

Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located the suprachiasmatic nuclei that coordinates timing cellular clocks tissues throughout body. The critical role this system is emphasized increasing evidence associating disruption with diverse pathologies. Accordingly, mounting suggests a bidirectional relationship where misalignment may contribute to liver diseases while alter other tissues. Therefore, pathophysiology broadly impact provide mechanistic framework for understanding targeting metabolic adjust setpoints.

Language: Английский

Citations

0
Circadian biology in obstructive sleep apnea associated cardiovascular disease DOI Creative Commons
Laetitia S. Gaspar,

Santoshi Pyakurel,

Na Xu

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Long‐term sub‐erythemal UVB exposure does not impact circadian rhythms in mice under standard and rotating shift light conditions DOI Creative Commons
Adam J. Greer,

Sean J. Cone,

Rachel Bernstein

et al.

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Abstract The International Agency for Research on Cancer (IARC) stated that circadian disruption is a potential carcinogen. However, the impact of environmental carcinogens, including sub‐erythemal doses UVB exposure, rhythms remains unclear. We evaluated long‐term rotating shift, loss Per1/2 genes, and chronic exposure SKH‐1 mice up to 7 months. Real‐time locomotion gene expression were measured in these animals. Mice under shift exhibited longer period activity 25.20 h, while those standard light conditions had clear 24‐h rhythm. mPer1/mPer2 mice, conversely, displayed shortened 23.61 h. Interestingly, no rhythms, though it induced skin tumors all mice. Rotating led dysregulation core clock with notable phase difference Cry1 . These findings provide novel insights into genetic influences rhythms.

Language: Английский

Citations

0
Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea DOI

R.R Hicks,

David Gozal, Sadia Ahmed

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106493 - 106493

Published: April 1, 2025

Language: Английский

Citations

0
Exploring differences in signaling pathways of the circadian clock and neuromodulators in obstructive sleep apnea DOI Creative Commons
Szymon Turkiewicz, Marcin Sochal,

Marta Ditmer

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 26, 2025

Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurring upper airway obstructions, leading to disrupted and systemic complications. The complexity of OSA suggests intricate interactions between neuromodulators circadian clock genes. This study aimed explore the expression levels rhythm genes neurotrophins (NTs) in patients compared controls. Participants (166 patients, 64 controls) were enrolled. Blood samples collected post-polysomnography (PSG), underwent RNA extraction from peripheral blood lymphocytes RT-PCR was performed for gene analysis. In group, BMAL1, CLOCK, CRY1, PER1, NPAS2, NR1D1, HIF-1β positively correlated with BDNF (p < 0.05 all). Conversely, control only PER1 mRNA showed correlation (R = 0.280, p 0.017). NF-κβ demonstrated positive HIF-1α, expressions both groups HIF-1α HIF1-β NR1D1 regardless presence underscores among genes, NTs, transcription factors OSA, providing basis potential targeted therapeutic interventions.

Language: Английский

Citations

0