Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation DOI

Mao Xu,

Shihui Yu, Pengyu Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 588 - 604

Published: Dec. 25, 2024

Language: Английский

Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infections DOI Creative Commons
Lucas A. Meirelles, Evangelia Vayena,

Auriane Debache

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Pseudomonas aeruginosa causes antibiotic-resilient acute and chronic pneumonia, but the mechanisms by which it adapts to airway environment are poorly understood. Here, we investigated P. pathoadaptive in tissue-engineered human organoids. Using transposon sequencing situ, decoded how survives on mucosal surface during antibiotic treatment. Biofilm formation emerged as a major driver of colonization. Mutants that extensively produce biofilms mucus show limited exploratory behavior, limits nutrient access, slowing down their growth. Conversely, biofilm-dwelling better tolerate antibiotics via biophysical mechanisms. Finally, can shelter less-tolerant more cytotoxic strains, thereby contributing genotypic heterogeneity. must therefore adapt conflicting physical biological selective pressures initiate infections.

Language: Английский

Citations

0

Microtopographic Influence on Bacterial Biofilm Development in Habitat-Like Environments DOI
Krishna Yadav, Kantrol Kumar Sahu,

Sucheta

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 106311 - 106311

Published: Oct. 1, 2024

Language: Английский

Citations

0

Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation DOI

Mao Xu,

Shihui Yu, Pengyu Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 588 - 604

Published: Dec. 25, 2024

Language: Английский

Citations

0