Published: Jan. 1, 2024
Language: Английский
Canadian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 15, 2024
Aspergillus fumigatus is a globally distributed mold and major cause of opportunistic infections in humans. Because most are from environmental exposure, it critical to understand populations A. fumigatus. Soil ecological niche for Here, we analyzed 748 soil isolates 21 locations six provinces one territory Canada. All were genotyped using nine microsatellite markers. Due small sample size and/or close proximities some local samples, these grouped into 16 geographic populations. Our results indicated high allelic genotypic diversities within provincial Interestingly, low but statistically significant genetic differentiations found among Canada, with relatively similar proportions strains genotypes belonging two large clusters. In Hamilton, Ontario, Vancouver, BC, where three analyzed, respectively, limited difference them. Most showed evidence both clonality recombination, no population showing random recombination. Of the here, resistant triazole antifungals. We discuss implications our evolution epidemiology
Language: Английский
Citations
1
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: May 31, 2024
Abstract Meiotic recombination is required for faithful chromosome segregation in most sexually reproducing organisms and shapes the distribution of genetic variation populations. Both overall rate spatial crossovers vary within between species. Adjacent on same tend to be spaced more evenly than expected at random, a phenomenon known as crossover interference. Although interference has been observed many taxa, factors that influence strength are not well understood. We used house mice ( Mus musculus ), well-established model system understanding recombination, study effects genetics age male germline. analyzed positions 503 progeny from reciprocal F1 hybrids inbred strains representing three major subspecies mice. Consistent with previous studies, autosomal alleles M. m. increase rate, while inheriting X decreases rate. Old males transmit an average 0.6 per meiosis (5.0%) young males, though effect varies across backgrounds. show depends genotype, providing rare demonstration evolves over short timescales. Differences F1s suggest X-linked modulate Our findings motivate additional comparisons among recently diverged species further examination role paternal determining number positioning crossovers.
Language: Английский
Citations
0
Genetics, Journal Year: 2024, Volume and Issue: 228(3)
Published: Sept. 6, 2024
Meiotic recombination is required for faithful chromosome segregation in most sexually reproducing organisms and shapes the distribution of genetic variation populations. Both overall rate spatial crossovers vary within between species. Adjacent on same tend to be spaced more evenly than expected at random, a phenomenon known as crossover interference. Although interference has been observed many taxa, factors that influence strength are not well understood. We used house mice (Mus musculus), well-established model system understanding recombination, study effects genetics age male germline. analyzed positions 503 progeny from reciprocal F1 hybrids inbred strains representing three major subspecies mice. Consistent with previous studies, autosomal alleles M. m. musculus increase rate, while inheriting X decreases rate. Old males transmit an average 0.6 per meiosis (5.0%) young males, though effect varies across backgrounds. show depends genotype, providing rare demonstration evolves over short timescales. Differences F1s suggest X-linked modulate Our findings motivate additional comparisons among recently diverged species further examination role paternal determining number positioning crossovers.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0