A Systematic Review of Light Therapy on Mental Health on and Beyond Earth DOI Open Access
Weiming Song, Avery Zheng,

Jingyang Wu

et al.

Psychology and Behavioral Sciences, Journal Year: 2024, Volume and Issue: 13(3), P. 75 - 87

Published: July 9, 2024

Light can influence human emotional well-being, sleep quality, and circadian rhythms. The application of these qualities in a therapeutic context is currently being explored. Research has been conducted into the effects light therapy on wound healing, enhancement, stress management, improvement depressive symptoms. Despite extensive amount studies this field, satisfactory framework for categorizing therapies yet to be developed. To address problem, our research team proposes categorize by wavelength (color). benefit categorization that, while applications may evolve, fundamental properties colors remain constant. Categorizing color supports scientific innovation maintains consistent categories even as new emerges. On other hand, therapy’s potential undermined. characterized its affordability, durability, consistency, minimal side effects. While interchangeable with methods common scenarios, it specifically suited environments where all those attributes are essential. Space missions represent one such environment. exploration major frontier humanity, mental health living conditions astronauts have received limited attention. present unique environmental challenges due altered exposure, high-pressure, isolated environments. These problems need addressed, but resource-scarce space environment requires reliable durable solution. advantages align well constraints. Moreover, ability issues disrupted rhythms psychological caused renders an optimal intervention exploration. This article will examine therapy, particular focus ways which different various recent discoveries. demonstrated through use illustrative example. Additionally, we briefly discuss future directions therapy. Our primary objective establish intuitive stable We environments, missions, how symptoms experienced during missions. ultimate goal fully realize tailored inspire discovery scenarios equally effective.

Language: Английский

Elevated dorsal medial prefrontal cortex to lateral habenula pathway activity mediates chronic stress-induced depressive and anxiety-like behaviors DOI
Xiaohan Tong,

Jijin Wu,

Ruizhe Sun

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(9), P. 1402 - 1411

Published: March 13, 2024

Language: Английский

Citations

10
The impact of bright light therapy on Parkinson's Disease: a pilot study using vestibular-evoked myogenic potentials DOI

Wei-Ye Xie,

Wen-Xiang Duan,

Ying Chen

et al.

Parkinsonism & Related Disorders, Journal Year: 2025, Volume and Issue: 134, P. 107776 - 107776

Published: March 10, 2025

Language: Английский

Citations

1
Burst firing in Output‐Defined Parallel Habenula Circuit Underlies the Antidepressant Effects of Bright Light Treatment DOI Creative Commons

Xian‐Wei Liu,

Han Li,

Ruijia Ma

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 11, 2024

Abstract Research highlights the significance of increased bursting in lateral habenula (LHb) neurons depression and as a focal point for bright light treatment (BLT). However, precise spike patterns LHb projecting to different brain regions during depression, their roles development, BLT's therapeutic action remain elusive. Here, are found dorsal raphe nucleus (DRN), ventral tegmental area (VTA), median (MnR) exhibit following aversive stimuli exposure, correlating with distinct depressive symptoms. Enhanced DRN‐projecting is pivotal anhedonia anxiety, while concurrent DRN, VTA, MnR essential despair. Remarkably, reducing neuron subpopulations underlies effects BLT on specific behaviors. These findings provide valuable insights into mechanisms antidepressant BLT.

Language: Английский

Citations

5
A Visual Circuit Linked To The Lateral Hypothalamus Mediates The Food Consumption-Suppressing And Weight Gain-Attenuating Effects Of Bright Light Treatment DOI Creative Commons
Lu Huang, Wen Li, Xiaodan Huang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract In addition to its well-established role in vision, environmental light also plays a crucial non-image-forming visual functions, including the regulation of instinctive behaviors such as feeding. Clinical evidence suggests that bright therapy can alleviate symptoms individuals with obesity. However, neural mechanisms underlying influence on feeding remain poorly understood. this study, we demonstrate treatment effectively reduces food intake and mitigates weight gain mice through circuit involving lateral hypothalamic area (LHA). Specifically, subset SMI-32-expressing ON-type retinal ganglion cells (RGCs) innervate GABAergic neurons ventral geniculate nucleus (vLGN), which turn inhibits LHA. Activation both vLGN-projecting RGCs vLGN-to-LHA pathway is sufficient suppress consumption attenuate gain. Importantly, provide direct suppressive effects rely activation retina-vLGN-LHA pathway. Together, our results delineate an LHA-related consumption-suppressing gain-attenuating treatment.

Language: Английский

Citations

0
Lateral habenula-rostromedial tegmental nucleus circuit mediates inflammatory pain in mice DOI Creative Commons

Yanfei Sun,

Jing Cao,

Chunpeng Xu

et al.

The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 6, 2025

Abstract Background The monoamine system, particularly the serotonergic neurons in dorsal raphe nucleus (DRN), associated with synthesis and release of 5-hydroxytryptamine, is crucial for regulating pain. lateral habenula (LHb) modulates DRN by acting through GABAergic located rostromedial tegmental (RMTg). However, role RMTg mediating LHb pain remains unclear. Thus, we aimed to assess LHb-RMTg pathway inflammatory Methods Male C57BL/6 mice were used chemogenetic experiments, while male female Vglut2-ires-cre optogenetic experiments; both model control groups established. We performed Hargreaves Von Frey tests nociceptive behavior as well immunohistochemistry staining after activation experiments. Statistical analyses using a t- test, one-way analysis variance (normally distributed data) or Kruskal–Wallis test (non-normally two-way variance. Results Chemogenetic activation/inhibition RMTg-projecting excitatory was sufficient decrease increase heat sensitivity thresholds. Additionally, inhibition circuit reversed decreased thresholds under conditions approaches. this did not affect mechanical allodynia thresholds, c-Fos immunoreactivity DRN. Conclusions Our results indicate that activating glutamatergic within heightens triggering RMTg, which turn influences neuronal activity This research offers fresh perspectives on mechanism, potentially revealing new therapeutic avenues managing Graphical

Language: Английский

Citations

0
Bright light therapy in Parkinson’s disease: a pilot study on visual pathway improvements DOI Creative Commons

Wei-Ye Xie,

Hong Lou,

Jiaying Liu

et al.

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 12, 2025

Bright light therapy (BLT) has been proved to have beneficial effects on Parkinson's disease (PD), the mechanisms remained unclear. Improvements of visual pathways might be key BLT. The aim this study is validate whether BLT improves clinical symptoms in PD and explore possible evaluated by optical coherence tomography (OCT), pattern electroretinogram (PERG) evoked potentials (VEP). Twenty-three patients were enrolled crossover randomized placebo-controlled study. Participants received either one month or dim (DLT), separated one-month wash-out period, followed another intervention. underwent scales, visual-related evaluations including OCT, PERG VEP before after each Mixed-effects regression models used determine effect between DLT improving differentials scales (Δscales), OCT (Δretinal thickness), (ΔPERG values) (ΔP100 latencies). Correlations improvements analyzed receiving Excessive daytime sleepiness, anxiety, life quality autonomic function improved Compared with DLT, bilateral ΔN95 latencies for ΔP100 We did not observe changes four quadrants retinal nerve fiber layer (RNFL) thickness DLT. a valuable safe non-pharmacological intervention patients. These findings extend neural improvements.

Language: Английский

Citations

0
Sleep and the recovery from stress DOI Creative Commons
Xiao Yu, Mathieu Nollet, Nicholas P. Franks

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

The relationship between stress and sleep is multifaceted, with capable of both disrupting promoting depending on the nature, intensity, duration stressor. While commonly leads to fragmentation arousal in humans animals, certain selective stressors, such as immune challenges psychosocial stress, promote rodent models. Specific neural circuits, those involving ventral tegmental area lateral habenula, mediate this stress-induced sleep. Post-stress may facilitate recovery, reduce anxiety, enhance resilience, but extent which versus wakefulness post-stress aids long-term adaptation unclear. Both human animal studies highlight a bidirectional relationship, where changes architecture have adaptive or maladaptive consequences. Here, we propose that contributes resilience discuss potential mechanisms underlying process. A deeper understanding these pathways provide new strategies for enhancing recovery improving mental health outcomes.

Language: Английский

Citations

0
A visual circuit related to the parabrachial nucleus for the antipruritic effects of bright light treatment DOI Creative Commons

Zhengfang Hu,

Xiaodan Huang,

Jianyu Liu

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(6), P. 114356 - 114356

Published: June 1, 2024

In addition to its role in vision, light also serves non-image-forming visual functions. Despite clinical evidence suggesting the antipruritic effects of bright treatment, circuit mechanisms underlying on itch-related behaviors remain poorly understood. this study, we demonstrate that treatment reduces mice through a related lateral parabrachial nucleus (LPBN). Specifically, subset retinal ganglion cells (RGCs) innervates GABAergic neurons ventral geniculate and intergeniculate leaflet (vLGN/IGL), which subsequently inhibit CaMKIIα+ LPBN. Activation both vLGN/IGL-projecting RGCs vLGN/IGL-to-LPBN projections is sufficient reduce induced by various pruritogens. Importantly, rely activation retina-vLGN/IGL-LPBN pathway. Collectively, our findings elucidate LPBN underlies treatment.

Language: Английский

Citations

2
The Impact of Non-Pharmacological Sleep Interventions on Delirium Prevention and Sleep Improvement in Postoperative ICU Patients: A Systematic Review and Network Meta-Analysis DOI Creative Commons
Jiaqi Li, Yingying Fan,

Ruoyu Luo

et al.

Intensive and Critical Care Nursing, Journal Year: 2024, Volume and Issue: 87, P. 103925 - 103925

Published: Dec. 21, 2024

Language: Английский

Citations

1
Outdoor artificial light at night and male sperm quality: A retrospective cohort study in China DOI

Run Tian,

Tingting Yang, Chenghan Xiao

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 341, P. 122927 - 122927

Published: Nov. 15, 2023

Language: Английский

Citations

3