Dynamics of two distinct memory interactions during water seeking in Drosophila

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(16)

Published: April 17, 2025

Forming and forgetting memories shape our self-awareness help us face future challenges. Therefore, understanding how are formed different interact in the brain is important. Previous studies have shown that thirsty flies sense humidity through ionotropic receptors, which them locate water sources. Here, we showed can be trained to associate specific odors with form a memory lasts for 30 min after association. Humidity formation requires Ir93a Ir40a essential environmental sensing. Water takes precedence, leading of by activating small subset dopaminergic neurons called protocerebral anterior medial (PAM)-γ4, project restricted region mushroom body (MB) γ lobes. Adult-stage-specific silencing Dop2R receptors MB prolongs 3 h. Live-brain calcium imaging dopamine sensor revealed significantly increased PAM-γ4 neural activity odor/humidity association, suggesting its role memory. Our results suggest overlapping circuits responsible acquisition flies.

Language: Английский

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How climate change might impact insect movement via physiological mechanisms

One Earth, Journal Year: 2024, Volume and Issue: 7(4), P. 608 - 622

Published: April 1, 2024

Language: Английский

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Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in Drosophila

Cells, Journal Year: 2023, Volume and Issue: 12(24), P. 2792 - 2792

Published: Dec. 8, 2023

Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme can cause injury or even death. Thus, thermosensation is important for survival However, mechanisms regulating remain unexplored, mostly because the complexity mammalian neural circuits. The fruit fly Drosophila melanogaster achieves desirable body temperature through ambient fluctuations, sunlight exposure, behavioral strategies. availability extensive genetic tools resources studying have enabled scientists to unravel underlying their preference. Over past 20 years, become an ideal model temperature-related genes This review provides comprehensive overview our current understanding preference Drosophila. It encompasses various aspects, such as by which flies sense temperature, effects internal external factors preference, adaptive strategies employed extreme-temperature environments. Understanding provide fundamental insights into molecular that control changes other

Language: Английский

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The Neural Correlations of Olfactory Associative Reward Memories in Drosophila

Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1716 - 1716

Published: Oct. 17, 2024

Advancing treatment to resolve human cognitive disorders requires a comprehensive understanding of the molecular signaling pathways underlying learning and memory. While most organ systems evolved maintain homeostasis, brain developed capacity perceive adapt environmental stimuli through continuous modification interactions within gene network functioning broader neural network. This distinctive characteristic enables significant plasticity, but complicates experimental investigations. A thorough examination mechanisms behavioral plasticity must integrate multiple levels biological organization, encompassing genetic individual neurons, among networks providing feedback on expression, observable phenotypic behaviors. Model organisms, such as

Language: Английский

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Mechanisms of learning and memory in Caenorhabditis elegans

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

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