Nervous system guides behavioral immunity in Caenorhabditis elegans DOI Creative Commons
Yu Wang,

Xuehong Sun,

Lixiang Feng

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18289 - e18289

Published: Oct. 15, 2024

is a versatile model organism for exploring complex biological systems. Microbes and the external environment can affect nervous system drive behavioral changes in

Language: Английский

The Roles of Distinct Transcriptional Factors in the Innate Immunity of C. elegans DOI Creative Commons
Muhammad Irfan Afridi, Haijun Tu

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 327 - 327

Published: Feb. 21, 2025

Deleterious molecules or factors produced by pathogens can hinder the normal physiological functioning of organisms. In response to these survival challenges, organisms rely on innate immune signaling as their first line defense, which regulates immune-responsive genes and antimicrobial peptides protect against pathogenic infections. These are under control transcription factors, known regulate transcriptional activity after binding regulatory sequences. Previous studies have employed Caenorhabditis elegans a host-pathogen interaction model demonstrate essential role different in immunity worms. this review, we summarize advances made regarding distinct upon pathogen infection. Finally, discuss open questions field, whose resolutions potential expand our understanding mechanisms underlying

Language: Английский

Citations

0
Patterns of pathogenesis in innate immunity: insights from C. elegans DOI
Samantha Y. Tse, Khursheed A. Wani, Read Pukkila-Worley

et al.

Nature reviews. Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

Citations

0
Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans DOI Creative Commons
Kenneth Liu, Manish Grover, Franziska Trusch

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(11), P. 114906 - 114906

Published: Oct. 25, 2024

Language: Английский

Citations

2
Paired C-type lectin receptors mediate specific recognition of divergent oomycete pathogens in C. elegans. DOI Creative Commons
Kenneth Liu, Manish Grover, Franziska Trusch

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 8, 2024

Summary Innate immune responses can be initiated through the detection of pathogen or damage-associated molecular patterns by host receptors that are often present on surface cells. While certain invertebrates like Caenorhabditis elegans lack professional cells, they still respond to infection in a pathogen-specific manner. It has been debated for years whether homologues canonical recognition also functioning nematode. Here we show C-type lectin mediate species-specific divergent oomycetes C. elegans. A CLEC-27/CLEC-35 pair is essential oomycete Myzocytiopsis humicola , while CLEC-26/CLEC-36 required Haptoglossa zoospora. Both clec pairs transcriptionally regulated shared promoter conserved PRD-like homeodomain transcription factor CEH-37/OTX2 and act sensory neurons anterior intestine trigger protective response epidermis. This system enables redundant tissue sensing threats CLEC defense via cross-tissue communication. Highlights zoospora co-regulated function redundantly

Language: Английский

Citations

0
Nervous system guides behavioral immunity in Caenorhabditis elegans DOI Creative Commons
Yu Wang,

Xuehong Sun,

Lixiang Feng

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18289 - e18289

Published: Oct. 15, 2024

is a versatile model organism for exploring complex biological systems. Microbes and the external environment can affect nervous system drive behavioral changes in

Language: Английский

Citations

0