Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels
The Journal of General Physiology,
Journal Year:
2025,
Volume and Issue:
157(3)
Published: Feb. 27, 2025
The
ctenophore
species
Mnemiopsis
leidyi
is
known
to
have
a
large
set
of
voltage-gated
K+
channels,
but
little
about
the
functional
diversity
these
channels
or
their
evolutionary
history
in
other
species.
Here,
we
searched
genomes
two
additional
species,
Beroe
ovata
and
Hormiphora
californensis,
for
functionally
expressed
subset
M.
channels.
We
found
that
last
common
ancestor
three
disparate
lineages
probably
had
at
least
33
Two
genes
belong
EAG
family,
remaining
31
Shaker
family
form
single
clade
within
animal/choanoflagellate
phylogeny.
additionally
evidence
10
transcriptome
early
branching
lineage
Euplokamis
dunlapae,
suggesting
diversification
was
already
underway
evolution.
16
Shakers
they
encode
diverse
array
conductances
with
orthologs
many
classic
subtypes
cnidarians
bilaterians.
Analysis
data
show
are
wide
variety
cell
types,
including
neurons,
muscle,
comb
cells,
colloblasts.
Ctenophores
therefore
appear
independently
evolved
much
channel
shared
between
Language: Английский
Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: Jan. 14, 2025
Abstract
MoeA,
also
known
as
gephyrin
in
higher
eukaryotes,
is
an
enzyme
essential
for
molybdenum
cofactor
(Moco)
biosynthesis
and
involved
GABA
GlyR
receptor
clustering
at
the
synapse
animals.
We
recently
discovered
that
Actinobacteria
have
a
repurposed
version
of
MoeA
(Glp)
linked
to
bacterial
cell
division.
Since
exists
all
domains
life,
our
study
explores
how
it
gained
multifunctionality
over
time.
use
phylogenetic
inference
protein
structure
analyses
its
diversity
evolutionary
history.
Glp-expressing
Bacteria
least
two
copies
gene,
analysis
their
putative
active
sites
suggests
Glp
lost
enzymatic
role.
In
Archaea,
we
find
ancestral
duplication,
with
one
paralog
may
bind
tungsten
instead
molybdenum.
Early
eukaryotes
acquired
from
Bacteria,
MogA
fused
opisthokont
ancestors,
finally
roles
anchoring
inhibitory
neurotransmitters.
Our
findings
highlight
MoeA’s
functional
versatility
repurposing.
Language: Английский
Morphogenesis of Fractofusus andersoni and the nature of early animal development
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 11, 2025
Language: Английский
OrthoHMM: Improved Inference of Ortholog Groups using Hidden Markov Models
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 12, 2024
Abstract
Accurate
orthology
inference
is
essential
for
comparative
genomics
and
phylogenomics.
However,
challenged
by
sequence
divergence,
which
pronounced
among
anciently
diverged
organisms.
We
present
OrthoHMM,
an
algorithm
that
infers
orthologous
gene
groups
using
Hidden
Markov
Models
parameterized
from
substitution
matrices,
enables
better
detection
of
remote
homologs.
Benchmarking
indicates
OrthoHMM
outperforms
currently
available
methods;
example,
a
curated
set
Bilaterian
orthogroups,
showed
10.3
–
138.9%
improvement
in
precision.
Rank-based
benchmarking
orthogroups
novel
dataset
organisms
three
major
eukaryotic
kingdoms
revealed
had
the
best
overall
performance
(6.7
97.8%
improvement).
These
findings
suggest
improve
orthogroup
inference.
Language: Английский