Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice

Frontiers in Human Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Feb. 11, 2025

Transcranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive external stimulation relative sham exposure. Here, we sought directly measure effect of tDUS on mouse activity subjected an stimulation—a blinking light. Using electrocorticography, observed a substantial increase in median due plus light baseline and Subsequent decreased after cessation but with continuation light, though it remained above demonstrated by mice exposed only In separate experiment, showed alone, without had no observable activity, upon its cessation, decreased. These results demonstrate simultaneous exposure receptivity visual cortex prior reduce subsequent activity. each case, these are consistent published data. Our echo do not explain them, since their test subjects received less intense than did our mice. Given near ubiquity systems, further progress along this line research could one day lead widespread use intentionally function during exogenous stimulation.

Language: Английский

---

Novel NIBS in psychiatry: Unveiling TUS and TI for research and treatment

Brain and Neuroscience Advances, Journal Year: 2025, Volume and Issue: 9

Published: March 1, 2025

Mental disorders pose a significant global burden and constitute major cause of disability worldwide. Despite strides in treatment, substantial number patients do not respond adequately, underscoring the urgency for innovative approaches. Traditional non-invasive brain stimulation techniques show promise, yet grapple with challenges regarding efficacy specificity. Variations mechanistic understanding reliability among methods are common, limited spatial precision physical constraints hindering ability to target subcortical areas often implicated disease aetiology. Novel such as transcranial ultrasonic temporal interference have gained notable momentum recent years, possibly addressing these shortcomings. Transcranial (TUS) offers exceptional deeper penetration compared conventional electrical magnetic techniques. Studies targeting diverse array regions shown its potential affect neuronal excitability, functional connectivity symptoms psychiatric depressive disorder. Nevertheless, planning acoustic interactions skull must be tackled widespread adoption research potentially clinical settings. Similar stimulation, (TI) traditional albeit requiring comparatively higher current equivalent neural effects. Promising still sparse highlights TI’s selectively modulate activity, showing utility psychiatry. Overall, like only open new avenues but also hold effective treatments However, realising their full necessitates practical optimising application effectively.

Language: Английский

---

Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Transcranial ultrasonic stimulation (TUS) redefines what is possible with non-invasive neuromodulation by oaering unparalleled spatial precision and flexible targeting capabilities. However, peripheral confounds pose a significant challenge to reliably implementing this technology. While auditory during TUS have been studied extensively, the somatosensory confound has overlooked thus far. It will become increasingly vital quantify manage as field shifts towards higher doses, more compact devices, frequent through temple where co-stimulation pronounced. Here, we provide systematic characterisation of TUS. We also identify conditions under which can be mitigated most eaectively mapping confound-parameter space. Specifically, investigate dose-response eaects, pulse shaping characteristics, transducer-specific parameters. demonstrate that avoiding near-field intensity peaks in scalp, spreading energy across greater area ramping envelope, delivering equivalent doses via longer, lower-intensity pulses rather than shorter, higher-intensity pulses. Additionally, repetition frequencies fundamental reduce eaects. Through our parameter space, find preliminary evidence particle displacement (strain) may primary biophysical driving force behind co-stimulation. This study provides actionable strategies minimise confounds, support thorough experimental control required unlock full potential for scientific research clinical interventions. Tactile, thermal, even painful occur TUS.Confounds & parameters.Valid replicable requires confounds.Particle confounds.

Language: Английский

---

Looking for the optimal pathway to stimulate the hippocampus in human participants using transcranial ultrasound stimulation: a simulation study

Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

JOURNAL/atin/04.03/02274269-990000000-00007/figure1/v/2025-05-11T061900Z/r/image-tiff Currently, very few methods can directly modulate neural activity in deep brain structures human participants. Low-intensity transcranial ultrasound stimulation, an emerging and advanced modality of non-invasive shows great potential for precisely stimulating subcortical associated with sleep, emotion, cognition, motor function. Due to its focal nature, integrating various methods, including magnetic resonance imaging pathways, is essential performing stimulation interventions that ensure precise targeting dosing. The aim this study was create simulation models low-intensity the hippocampus through lateral, anterior, posterior pathways. We compared effects these identify optimal pathway hippocampus. Eight healthy young adults underwent structural scans as part study. Utilizing their neuroimaging data, we developed a protocol hippocampal three pathways using K-Plan platform, followed by acoustic thermal simulations. results indicated via lateral most effective, delivering highest power route. Additionally, geometric characteristics thickness skull, along distance from scalp cortex, significantly influenced dosage. These findings are crucial step toward developing personalized treatment protocols, identified option. skull scalp-to-cortex accurately determining targets calculating doses.

Language: Английский

---

The promises and challenges of neurotechnology to improve human health and cognition

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(10), P. e3002903 - e3002903

Published: Oct. 30, 2024

This PLOS Biology collection explores the present and possible futures of neurotechnology to improve human health cognition, as well scientific, technological ethical challenges they face.

Language: Английский

---