The Cell-Intrinsic Circadian Clock is Dispensable for Lateral Posterior Clock Neuron Regulation of Drosophila Rest-Activity Rhythms DOI Creative Commons
Carlos Guerrero, Matthew F. Cusick,

Amanda J Samaras

et al.

Neurobiology of Sleep and Circadian Rhythms, Journal Year: 2025, Volume and Issue: 18, P. 100124 - 100124

Published: April 28, 2025

Circadian control of behavior arises from intercommunication among a distributed network circadian clock neurons in the brain. Single-cell sequencing and brain connectome data support division ∼240 Drosophila into ∼20 subclusters, functional studies demonstrate that these populations differentially contribute to behavioral outputs. Here, we have used genetic tools enable highly selective, cell-specific manipulations investigate role molecular function neuronal activity within lateral posterior (LPNs) regulation rest-activity rhythms. We find silencing neurons, which compromises signaling with downstream targets, substantially reduces strength free-running In contrast, locomotor patterns are robust CRISPR-mediated disruption cycling LPNs. conclude LPNs act as driven oscillators retain capacity transmit information absence cell-intrinsic clocks.

Language: Английский

Regulation of pre-dawn arousal in Drosophila by a pair of trissinergic descending neurons of the visual and circadian networks DOI
Rays H. Y. Jiang,

Yue Tian,

Xin Yuan

et al.

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The Cell-Intrinsic Circadian Clock is Dispensable for Lateral Posterior Clock Neuron Regulation of Drosophila Rest-Activity Rhythms DOI Creative Commons
Carlos Guerrero, Matthew F. Cusick,

Amanda J Samaras

et al.

Neurobiology of Sleep and Circadian Rhythms, Journal Year: 2025, Volume and Issue: 18, P. 100124 - 100124

Published: April 28, 2025

Circadian control of behavior arises from intercommunication among a distributed network circadian clock neurons in the brain. Single-cell sequencing and brain connectome data support division ∼240 Drosophila into ∼20 subclusters, functional studies demonstrate that these populations differentially contribute to behavioral outputs. Here, we have used genetic tools enable highly selective, cell-specific manipulations investigate role molecular function neuronal activity within lateral posterior (LPNs) regulation rest-activity rhythms. We find silencing neurons, which compromises signaling with downstream targets, substantially reduces strength free-running In contrast, locomotor patterns are robust CRISPR-mediated disruption cycling LPNs. conclude LPNs act as driven oscillators retain capacity transmit information absence cell-intrinsic clocks.

Language: Английский

Citations

0