Germline mutation rates and fine-scale recombination parameters in zebra finch DOI Creative Commons
Djivan Prentout, Daria Bykova, Carla Hoge

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011661 - e1011661

Published: April 15, 2025

Most of our understanding the fundamental processes mutation and recombination stems from a handful disparate model organisms pedigree studies mammals, with little known about other vertebrates. To gain broader comparative perspective, we focused on zebra finch ( Taeniopygia castanotis ), which, like birds, differs mammals in its karyotype (which includes many micro-chromosomes), mechanism by which is directed to genome, aspects ontogenesis. We collected genome sequences three generation pedigrees that provide information 80 meioses, inferring 202 single-point de novo mutations, 1,088 crossovers, 275 non-crossovers. On basis, estimated sex-averaged rate 5.0 × 10 -9 per base pair generation, par have similar time (~2–3 years). Also as found paternal germline bias at later stages gametogenesis (of 1.7:1) but no discernible difference between sexes early development. Examining patterns, crossover macro-chromosomes 0.93 cM/Mb, pronounced enrichment crossovers near telomeres. In contrast, non-crossover rates are more uniformly distributed. micro-chromosomes, substantially higher (3.96 cM/Mb), accordance homeostasis, both events At finer scale, overlap CpG islands often than expected chance, absence PRDM9. Estimates degree GC-biased gene conversion (59%), mean tract length (~32 bp), non-crossover-to-crossover ratio (5.4:1) all comparable those reported primates mice. Therefore, properties resolutions remain over large phylogenetic distances.

Language: Английский

Conserved features of recombination control in vertebrates DOI Creative Commons
Linda Odenthal-Hesse

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(1), P. e3002959 - e3002959

Published: Jan. 7, 2025

A recent study in PLOS Biology on the epigenetic recombination regulator PRDM9 salmonid fish reveals that its function has been preserved across vertebrates for hundreds of millions years, with rapidly evolving DNA-binding domains being a defining attribute.

Language: Английский

Citations

0
Germline mutation rates and fine-scale recombination parameters in zebra finch DOI Creative Commons
Djivan Prentout, Daria Bykova, Carla Hoge

et al.

PLoS Genetics, Journal Year: 2025, Volume and Issue: 21(4), P. e1011661 - e1011661

Published: April 15, 2025

Most of our understanding the fundamental processes mutation and recombination stems from a handful disparate model organisms pedigree studies mammals, with little known about other vertebrates. To gain broader comparative perspective, we focused on zebra finch ( Taeniopygia castanotis ), which, like birds, differs mammals in its karyotype (which includes many micro-chromosomes), mechanism by which is directed to genome, aspects ontogenesis. We collected genome sequences three generation pedigrees that provide information 80 meioses, inferring 202 single-point de novo mutations, 1,088 crossovers, 275 non-crossovers. On basis, estimated sex-averaged rate 5.0 × 10 -9 per base pair generation, par have similar time (~2–3 years). Also as found paternal germline bias at later stages gametogenesis (of 1.7:1) but no discernible difference between sexes early development. Examining patterns, crossover macro-chromosomes 0.93 cM/Mb, pronounced enrichment crossovers near telomeres. In contrast, non-crossover rates are more uniformly distributed. micro-chromosomes, substantially higher (3.96 cM/Mb), accordance homeostasis, both events At finer scale, overlap CpG islands often than expected chance, absence PRDM9. Estimates degree GC-biased gene conversion (59%), mean tract length (~32 bp), non-crossover-to-crossover ratio (5.4:1) all comparable those reported primates mice. Therefore, properties resolutions remain over large phylogenetic distances.

Language: Английский

Citations

0