Impact of maternal factors and environmental stress on sex ratio in Southern Poland DOI Creative Commons
Joanna Nieczuja-Dwojacka, Justyna Marchewka, Alicja Budnik

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: July 18, 2023

Abstract The secondary sex ratio (SRB) is a widely used descriptor that reflects the living conditions and health status during pregnancy. aim of study was to assess impact maternal factors, season birth, air pollution with heating on at birth in Subcarpathian population from Krosno district. A retrospective involving 11,587 births occurred John Paul II Podkarpackie Province Hospital between 2016 2020. Sex newborn, their as well age, order, interval births, were analysed. Furthermore, relationship SRB level investigated. To determine significance differences ratios, chi-square analysis multifactorial regression used, set p < 0.05. At level, all studied factors indicated statistically significant SRB. However, model shows age order most important shaping group.

Language: Английский

Factors influencing sex ratio at birth in Krosno, Poland DOI Creative Commons
Joanna Nieczuja-Dwojacka, Justyna Marchewka, Alicja Budnik

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 2, 2024

Abstract The secondary sex ratio (SSR) is a widely used descriptor that reflects the living conditions and health status during pregnancy. aim of study was to assess impact maternal factors, season birth, air pollution with heating on at birth in Subcarpathian population from Krosno district, Poland. A retrospective involving 11,587 births occurred John Paul II Podkarpackie Province Hospital between 2016 2020. Sex newborn, their as well age, order, interval births, were analysed. Furthermore, relationship SSR level investigated. To determine significance differences ratios, chi-square analysis multifactorial regression used, set p < 0.05. At level, all studied factors indicated statistically significant SSR. However, model shows age order most important shaping group.

Language: Английский

Citations

5

Gender bias in fetal malformations: A cross-sectional study in Asian populations DOI Creative Commons
Meixiang Zhang,

Yingchun Su,

Yingpu Sun

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: March 30, 2023

Objectives The aim of this study was to detect any gender bias in fetal malformation cases. Design This a cross-sectional, quantitative survey. Subjects Overall, 1,661 Asian cases involving induced abortions the obstetrics department first Affiliated Hospital Zhengzhou University from 2012 2021 were included. Main outcome measures Measurements ultrasound detectable structural malformations classified into 13 subtypes. Karyotyping, single nucleotide polymorphism (SNP) array, or sequencing diagnosis these fetus also included measures. Results sex ratio (male/female) all types 1.446. Cardiopulmonary had highest proportion with 28%. Diaphragmatic hernia, omphalocele, gastroschisis, nuchal translucency (NT), and Multy significantly higher proportions males ( p &lt; 0.05). Digestive system females Maternal age associated genetic factors r = 0.953, 0.001) inversely brain −0.570, 0.002). More found trisomy 21, 18, monogenetic diseases, while duplications, deletions, uniparental disomy (UPD) similar ratios between females, but not statistically significant. Conclusion Sex differences are common malformations, males. Genetic testing has been proposed account for differences.

Language: Английский

Citations

3

Sexing of Embryos at the Time of Twin Reduction: A Clinical Approach DOI Creative Commons

Fernando López‐Gatius,

I. García‐Ispierto

Animals, Journal Year: 2023, Volume and Issue: 13(8), P. 1326 - 1326

Published: April 12, 2023

This study provides new unique information on bovine twin pairs during the late embryonic period (28-34 days of pregnancy) in relation to (1) a predictive ultrasound measurement that was differential for sexing heterosexual twins; (2) intrauterine growth patterns pairs; and (3) higher vulnerability female embryos compared males following an induced embryo reduction twins. The population comprised 92 dairy cows carrying bilateral A length difference between co-twins equal or greater than 25% around 50% pregnancies served determine sex with 100% accuracy twins, which assessed four weeks later remaining fetus after reduction. apparent rates individual male from day 28 34 gestation were similar established pattern standards singletons. Mean sizes gestational age smaller by some 5 days' equivalent twins After risk loss null. allowed selection at time

Language: Английский

Citations

2

The impact of catastrophic events on the sex ratio at birth: A systematic review DOI Creative Commons
Lilybeth Fontanesi, Maria Cristina Verrocchio,

Melissa D’Ettorre

et al.

American Journal of Human Biology, Journal Year: 2023, Volume and Issue: 36(4)

Published: Nov. 2, 2023

Abstract Objective The impact of maternal stress on birth outcomes is well established in the scientific research. sex ratio at (SRB), namely male to female live births, shows significant alteration when mothers experience acute conditions, as proposed by Trivers‐Willard Hypothesis. We aimed synthetize literature relationship between two exogenous and catastrophic stressful events (natural disasters epidemics) SRB. Methods A systematic search was run Scopus, PubMed, Web Science, Cochrane Library, until March 9, 2023. produced 1336 articles 25 met inclusion criteria. found seven case–control studies 18 observational studies. Most investigated earthquakes other natural disasters. Only examined effect epidemics or pandemics. Results results seem inconsistent, 16 a decline SRB, three rise, four did not record any change gave contradictory results. period population analyzed, source information, method variance analysis failure assess confounding variables may have influenced incongruence Conclusion Our findings contribute improve knowledge about socio‐ecological factors Future should investigate mechanisms which this impacts public health, particular health pregnant women their newborn, through an accurate consistent methodology that also includes factors.

Language: Английский

Citations

2

Sex ratio at birth: causes of variation and narrative review of literature DOI

Angela D’Alfonso,

Manuela LUDOVISI,

Patrizia PALERMO

et al.

Minerva Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 75(2)

Published: March 3, 2022

The human sex ratio at birth (SRB) is the parameter which reflects relationship between males and females birth. It not 50:50, but approximately 0.515 in favor of males. There are many factors that can influence SRB its variations easily demonstrable.Our aim was to investigate environmental agents capable causing by providing a narrative review scientific literature.Studies demonstrated male female embryos/fetuses' response stress different way ones show less resistance. This phenomenon seems persist for six months after stressful event, suggesting purpose reproductive regulation protection perpetuation species. Although dependence with parenting decisions, thanks prenatal diagnosis assisted fertility techniques understood, it more complex correlate pressures act through secondary mechanisms. Covid-19 pandemic, natural catastrophes, terroristic attacks, economic crises some difficulties encountered recent times.The impact all reported explained only possible priori determination conception, also effects pregnancy outcomes. Thus, appears be multifactorial mechanism, besides matter genetics. pandemic climate changes present important opportunities research possibly reaching certain answers.

Language: Английский

Citations

3

Possibilities of the Cultural-Historical Approach to Gender Issues DOI Creative Commons
А.Ш. Тхостов,

Sergey K. Kumchenko

Moscow University Psychology Bulletin, Journal Year: 2024, Volume and Issue: 47(1), P. 11 - 30

Published: Jan. 1, 2024

Background. The relevance of gender issues is associated with discussions outside the scientific field, while in science itself, popularity studies increasing every year. Objectives. present article aims at application conceptual mechanism cultural-historical approach to issues. Methods. Abstraction, analysis and synthesis literary data, comparison theoretical models, generalization were used. Results. Sex as a biological entity divided into an innate “natural” category culturological one. A number examples demonstrate non-identity sex well variants their combination interaction. It proposed disidentify identity psychological category. latter understood analogue higher mental function which forms intravitally under specific social conditions, it mediated by signs (appearance, manners, norms, preferences, values, taboos, etc.) possible self-regulate. In meantime, limitations mastering one's own behaviour are emphasized, since origin connected parameters sex, inconsistency norms wide field influence. Here cultural pathology sphere intersex interaction reveals itself. Conclusions. seen be heuristic multifactorial understanding include biological, cultural, psychological, ontogenetic aspects.

Language: Английский

Citations

0

Sex ratio at birth across 100 years in Sweden and risk of cardiovascular disease and all-cause mortality – a national register study DOI Creative Commons
Peter M. Nilsson, Kristina Sundquist, Jan Sundquist

et al.

European Journal of Epidemiology, Journal Year: 2024, Volume and Issue: 39(9), P. 967 - 976

Published: July 15, 2024

Abstract The human sex ratio at birth (SRB) undergoes temporary changes around a mean proportion of 0.51 male births. SRB has been well studied for historical, geographical, and secular trends, but until now not linked to health outcomes in the total population, e.g. cardiovascular disease (CVD) or mortality during follow-up cohorts. We used linkage analysis based on national registers Sweden that cover all births from 1900 2016. was calculated by every 10-year cohort survivors living 1997 risk CVD with data registers. When highest quartile as reference, slightly increased fatal (HR 1.03 (95% confidence intervals, CI): 1.02–1.04), non-fatal 1.01; 95%CI: 1.01–1.02) 1.02; 95%CI, 1.01–1.03) found after full adjustments men belonging lowest quartile. A similar pattern also CHD women. SBR compared highest, HR (95%CI: 1.02–1.05). In conclusion, cohorts relatively lower than expected number males born, long-term adverse effects were observed population level. This could indicate so-called “culled cohorts” developed country 20th century are characterized reflect negative early life influences environmental exposures pregnant women resulting selective loss embryos fetuses. public perspective be some importance monitor an aspect statistics minor effects.

Language: Английский

Citations

0

Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposure DOI

Kelly Chau,

Kari Neier, Anthony E. Valenzuela

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Neurodevelopmental disorders have a strong male bias that is poorly understood. Placenta rich source of molecular information about environmental interactions with genetics (including biological sex), affect the developing brain. We investigated placental-brain transcriptional responses in an established mouse model prenatal exposure to human-relevant mixture polychlorinated biphenyls (PCBs).

Language: Английский

Citations

0

X Chromosome Inactivation Timing is Not eXACT: Implications for Autism Spectrum Disorders DOI Creative Commons
Janine M. LaSalle

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: March 9, 2022

The etiology of autism spectrum disorders (ASD) is complex, involving different combinations genetic and environmental factors. My lab's approach has been to investigate DNA methylation as a tractable genome-wide modification at the interface these complex interactions, reflecting past future events in molecular pathogenesis ASD. Since X-linked genes were enriched differences discovered from cord blood newborns later diagnosed with ASD, this prompted me review revisit recent advancements field X chromosome inactivation (XCI), particularly humans other primates. In Perspective, I compare XCI mechanisms mammalian species, including finding noncoding transcript XACT associated erosion human pluripotent stem cells findings non-human primate post-implantation embryos. focus on experimentally challenging peri- stages development when timing prolonged imprecise humans. Collectively, research raised some important unanswered questions biased sex ratios births male bias incidence

Language: Английский

Citations

2

Peri- and Post-natal Risk Factors Associated with Health of Newborns DOI Creative Commons
Yanan Long, Atif Ali Khan, Andrey Rzhetsky

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 14, 2023

Designing prophylactic strategies for newborns requires understanding of the factors that contribute to immunity and resistance infection. We analyzed 1,892,035 mother-newborn pairs in which both mother newborn were observed continuously at least one year before after birth. As part this study, we considered maternal exposures infections immune disorders during pregnancy, anti-infection medications by newborn, as well newborn's delivery type reported complications. According our analyses, infection rates disorder over-dispersed among newborns. The most consequential predicting newborns' health preterm birth, with 276.3% 193.9% risk increases bacterial infections. Newborn anti-infective prescriptions associated considerable diseases affecting health, while fewer outcomes mixed signs. Cesarean section mode delivery, mother's age, sex exposure all showed significant but smaller effects on health. Female appeared be better protected against system etiology, except miscellaneous

Language: Английский

Citations

0