Genomic epidemiology reveals 2022 mpox epidemic in New York City governed by heavy-tailed sexual contact networks DOI Creative Commons
Jonathan E. Pekar, Yibin Wang, Jade Wang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract The global mpox epidemic in 2022 was likely caused by transmission of virus (MPXV) through sexual contact networks, with New York City (NYC) experiencing the first and largest outbreak United States. By performing a phylogeographic epidemiological analysis MPXV, we identify at least 200 introductions MPXV into NYC 84 leading to onward transmission. Through comparative human immunodeficiency (HIV) NYC, find that both HIV genomic cluster sizes are best fit scale-free distributions people clusters more have previously received an diagnosis (odds ratio=1.58; p =0.012) be member recently growing cluster, indicating overlapping networks. We then model networks show highly connected individuals would disproportionately infected start epidemic, thereby resulting exhaustion most densely parts network. This dynamic explains rapid expansion decline outbreak, as well estimated cumulative incidence less than 2% within high-risk populations. synthesizing epidemiology modeling, demonstrate dynamics can understood general principles sexually transmitted pathogens.

Language: Английский

Transmission dynamics of the 2022 mpox epidemic in New York City DOI Creative Commons
Jonathan E. Pekar, Yu Wang, Jade Wang

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract The 2022 global mpox epidemic was caused by transmission of MPXV clade IIb, lineage B.1 through sexual contact networks, with New York City (NYC) experiencing the first and largest outbreak in United States. By performing phylogeographic analysis genomes sampled from 757 individuals NYC between April 2023, 3,287 around world, we identify over 200 introductions into at least 84 leading to onward transmission. These infections primarily occurred among men who have sex men, transgender women nonbinary individuals. Through a comparative HIV NYC, find that both genomic cluster sizes are best fit scale-free distributions, people clusters more likely previously received an diagnosis be member recently growing cluster. We model networks show highly connected would disproportionately infected start epidemic, which result exhaustion most densely parts network, and, therefore, explain rapid expansion decline outbreak. coupling epidemiology modeling, demonstrate dynamics can understood general principles sexually transmitted pathogens.

Language: Английский

Citations

0
Genomic epidemiology reveals 2022 mpox epidemic in New York City governed by heavy-tailed sexual contact networks DOI Creative Commons
Jonathan E. Pekar, Yibin Wang, Jade Wang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract The global mpox epidemic in 2022 was likely caused by transmission of virus (MPXV) through sexual contact networks, with New York City (NYC) experiencing the first and largest outbreak United States. By performing a phylogeographic epidemiological analysis MPXV, we identify at least 200 introductions MPXV into NYC 84 leading to onward transmission. Through comparative human immunodeficiency (HIV) NYC, find that both HIV genomic cluster sizes are best fit scale-free distributions people clusters more have previously received an diagnosis (odds ratio=1.58; p =0.012) be member recently growing cluster, indicating overlapping networks. We then model networks show highly connected individuals would disproportionately infected start epidemic, thereby resulting exhaustion most densely parts network. This dynamic explains rapid expansion decline outbreak, as well estimated cumulative incidence less than 2% within high-risk populations. synthesizing epidemiology modeling, demonstrate dynamics can understood general principles sexually transmitted pathogens.

Language: Английский

Citations

0