bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Summary Adaptive behavior depends on the ability to predict specific events, particularly those related rewards. Armed with such associative information, we can infer current value of predicted rewards based changing circumstances and desires. To support this ability, neural systems must represent both identity rewards, these representations be updated when they change. Here tested whether prediction error signaling dopamine neurons two areas known specifics rewarding HC OFC. We monitored spiking activity in rat VTA during changes number or flavor expected designed induce errors reward identity, respectively. In control animals, registered types, transiently increasing firing additional drops flavor. These canonical signatures were significantly disrupted rats ipsilateral neurotoxic lesions either Specifically, caused a failure register type error, whereas OFC persistent much more subtle effects errors. results demonstrate that contribute distinct types information computation signaled by dopaminergic neurons.

Language: Английский