Advances in Research and Treatment on Patients with Alzheimer's disease Induced by Sleep disorders DOI Creative Commons
Sijing Li

Highlights in Science Engineering and Technology, Journal Year: 2022, Volume and Issue: 8, P. 396 - 405

Published: Aug. 17, 2022

Alzheimer's disease (AD) is a characterized by memory impairment, loss of words and inability in emotional control that occurs the early intermediate stage end our lives. A number studies have shown incidence severity AD higher patients with sleep disorders than healthy people. The pathogenic mechanism still inconclusive, while several hypotheses been proposed according to its etiological characteristics: Some suggest β-amyloid protein hypothesis abnormal phosphorylation tau induced may be key factors leading AD. This paper will summarize mechanisms discuss current therapies approaches it, which included pharmacological therapy, using Trazodone, Midazolam Maleate tablets, Gardenia Citrusaurantium capsules as well non-pharmacological use aerobic exercise light promoting idea relieving an adjunctive treatment for contents summarized this some significance reference direction disorders.

Language: Английский

The PAICE Suite Reveals Circadian Post-Transcriptional Timing of Non-Coding RNAs and Spliceosome Components in Mus musculus Macrophages DOI Creative Commons
Sharleen M. Buel, Shayom Debopadhaya, Hannah De los Santos

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: April 10, 2022

ABSTRACT Circadian rhythms broadly regulate physiological functions by tuning oscillations in the levels of mRNAs and proteins to 24-hour day/night cycle. Globally assessing which are timed clock necessitates accurate recognition RNA protein data, particularly large omics data sets. Tools that employ fixed-amplitude models have previously been used positive effect. However, amplitude-change circadian required a new generation analytical software enhance identification these oscillations. To address this gap, we created Pipeline for Amplitude Integration Exploration (PAICE) suite. Here, demonstrate PAICE suite’s increased detection trends through joint modeling Mus musculus macrophage transcriptome proteome. Our enhanced confirmed extensive post-transcriptional regulation macrophages, but highlighted some reported discrepancy between mRNA was due noise data. We further applied suite investigate timing non-coding RNAs, documenting long RNAs small nuclear control spliceosome complex. By tracking oscillating complex using suite, noted regulates spliceosome, major As most above-noted had damped amplitude changes their oscillations, work highlights importance thorough enumeration omics-scale datasets.

Language: Английский

Citations

0
A Preliminary Study on the Relationship between Serum Heparan Sulfate and Cancer-Related Cognitive Impairment: The Moderating Role of Oxidative Stress in Patients with Colorectal Cancer DOI Creative Commons
Danhui Wang, Teng Wang, Min Zhu

et al.

Current Oncology, Journal Year: 2022, Volume and Issue: 29(4), P. 2681 - 2694

Published: April 12, 2022

Cancer-related cognitive impairment (CRCI) has been frequently reported in colorectal cancer survivors. Heparan sulfate (HS) was gradually considered to be related disorders. The effect and potential mechanism of HS on CRCI patients were unexplored. In this study, all participants divided into a impaired group normal group. concentrations oxidative stress factors serum detected. Associations among HS, evaluated. Participants with exhibited increased levels GSH, SOD MDA, compared the performance. independent significant association found between after controlling for various covariates. higher decreased performance survivors who GSH (β = 0.080, p 0.002). Moreover, nonlinear level scores confirmed using restricted cubic splines (p < 0.001). These results indicated that circulating had negative connection survivors, which moderated by GSH. might new biomolecule identification management CRCI.

Language: Английский

Citations

0
Emerging Life Sciences Series: Q&A with the Editor Circadian Biology DOI
Monty Montano

Advanced Biology, Journal Year: 2022, Volume and Issue: 6(6)

Published: June 1, 2022

Language: Английский

Citations

0
Advances in Research and Treatment on Patients with Alzheimer's disease Induced by Sleep disorders DOI Creative Commons
Sijing Li

Highlights in Science Engineering and Technology, Journal Year: 2022, Volume and Issue: 8, P. 396 - 405

Published: Aug. 17, 2022

Alzheimer's disease (AD) is a characterized by memory impairment, loss of words and inability in emotional control that occurs the early intermediate stage end our lives. A number studies have shown incidence severity AD higher patients with sleep disorders than healthy people. The pathogenic mechanism still inconclusive, while several hypotheses been proposed according to its etiological characteristics: Some suggest β-amyloid protein hypothesis abnormal phosphorylation tau induced may be key factors leading AD. This paper will summarize mechanisms discuss current therapies approaches it, which included pharmacological therapy, using Trazodone, Midazolam Maleate tablets, Gardenia Citrusaurantium capsules as well non-pharmacological use aerobic exercise light promoting idea relieving an adjunctive treatment for contents summarized this some significance reference direction disorders.

Language: Английский

Citations

0