Mutual repression between JNK/AP-1 and JAK/STAT stratifies senescent and proliferative cell behaviors during tissue regeneration
Janhvi Jaiswal,
No information about this author
Janine Egert,
No information about this author
Raphael Engesser
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et al.
PLoS Biology,
Journal Year:
2023,
Volume and Issue:
21(5), P. e3001665 - e3001665
Published: May 30, 2023
Epithelial
repair
relies
on
the
activation
of
stress
signaling
pathways
to
coordinate
tissue
repair.
Their
deregulation
is
implicated
in
chronic
wound
and
cancer
pathologies.
Using
TNF-α/Eiger-mediated
inflammatory
damage
Drosophila
imaginal
discs,
we
investigate
how
spatial
patterns
behaviors
arise.
We
find
that
Eiger
expression,
which
drives
JNK/AP-1
signaling,
transiently
arrests
proliferation
cells
center
associated
with
a
senescence
program.
This
includes
production
mitogenic
ligands
Upd
family,
allows
JNK/AP-1-signaling
act
as
paracrine
organizers
regeneration.
Surprisingly,
cell-autonomously
suppress
via
Ptp61F
Socs36E,
both
negative
regulators
JAK/STAT
signaling.
As
suppressed
at
damage,
compensatory
occurs
by
periphery.
Mathematical
modelling
suggests
cell-autonomous
mutual
repression
between
core
regulatory
network
essential
spatially
separate
into
bistable
domains
distinct
cellular
tasks.
Such
stratification
for
proper
repair,
coactivation
same
creates
conflicting
signals
cell
cycle
progression,
leading
excess
apoptosis
senescently
stalled
organize
field.
Finally,
demonstrate
separation
senescent
proliferative
not
only
upon
but
also
Ras
V12
,
scrib
tumors.
Revealing
this
previously
uncharacterized
JNK/AP-1,
JAK/STAT,
has
important
implications
our
conceptual
understanding
pathologies,
tumor
microenvironments.
Language: Английский
Inter-organ communication during tissue regeneration
Development,
Journal Year:
2023,
Volume and Issue:
150(23)
Published: Nov. 27, 2023
ABSTRACT
Tissue
regeneration
is
not
simply
a
local
repair
event
occurring
in
isolation
from
the
distant,
uninjured
parts
of
body.
Rather,
evidence
indicates
that
whole-animal
process
involving
coordinated
interactions
between
different
organ
systems.
Here,
we
review
recent
studies
reveal
how
remote
tissues
and
systems
respond
to
engage
regeneration.
We
also
discuss
need
for
toolkits
technological
advancements
uncover
dissect
communication
during
Language: Английский
Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis
Development,
Journal Year:
2024,
Volume and Issue:
151(20)
Published: July 2, 2024
ABSTRACT
The
capacity
to
regenerate
lost
tissues
varies
significantly
among
animals.
Some
phyla,
such
as
the
annelids,
display
substantial
regenerating
abilities,
although
little
is
known
about
cellular
mechanisms
underlying
process.
To
precisely
determine
origin,
plasticity
and
fate
of
cells
participating
in
blastema
formation
posterior
end
regeneration
after
amputation
annelid
Platynereis
dumerilii,
we
developed
specific
tools
track
different
cell
populations.
Using
these
tools,
find
that
partly
promoted
by
a
population
proliferative
gut
whose
regenerative
potential
function
their
position
along
antero-posterior
axis
worm.
Gut
progenitors
from
anterior
differentiated
are
lineage
restricted,
whereas
less
more
much
plastic.
However,
they
unable
stem
responsible
for
growth
worms.
Those
local
deriving
present
segment
abutting
plane,
most
cells.
Our
results
favour
hybrid
flexible
model
relying
on
degrees
plasticity.
Language: Английский
Coordination of cell cycle and morphogenesis during organ formation
eLife,
Journal Year:
2024,
Volume and Issue:
13
Published: Jan. 26, 2024
Organ
formation
requires
precise
regulation
of
cell
cycle
and
morphogenetic
events.
Using
the
Drosophila
embryonic
salivary
gland
(SG)
as
a
model,
we
uncover
role
SP1/KLF
transcription
factor
Huckebein
(Hkb)
in
coordinating
morphogenesis.
The
hkb
mutant
SG
exhibits
defects
invagination
positioning
organ
size
due
to
abnormal
death
cells.
Normal
development
involves
distal-to-proximal
progression
endoreplication
(endocycle),
whereas
cells
undergo
division,
leading
death.
Hkb
represses
expression
key
pro-apoptotic
genes
SG.
Knockdown
cyclin
E
or
cyclin-dependent
kinase
1,
overexpression
fizzy-related
rescues
most
observed
These
results
indicate
that
plays
critical
controlling
by
regulating
effectors
ensure
proper
formation.
Language: Английский
Antero-posterior gradients of cell plasticity and proliferation modulate posterior regeneration in the annelidPlatynereis
Loïc Bideau,
No information about this author
Loeiza Baduel,
No information about this author
Marianne Basso
No information about this author
et al.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 12, 2023
Abstract
Regenerative
abilities
are
extremely
variable
among
animals
and
may
be
substantial
in
some
phyla,
such
as
the
annelids.
So
far,
cellular
mechanisms
underlying
regeneration
annelids
remain
elusive.
To
precisely
determine
origin(s),
plasticity
fate
of
cells
participating
blastema
formation
during
posterior
annelid
Platynereis
dumerilii
,
we
developed
specific
tools
to
track
proliferative
well
gut
epithelial
cells.
We
showed
that
two
populations
progenitors
at
play
that,
them,
from
differentiated
tissues
lineage-restricted.
Strikingly,
less
more
much
plastic
can
produce
ectodermal
mesodermal
derivatives,
addition
However,
their
is
de
facto
limited
exemplified
by
inability
regenerate
stem
responsible
for
constant
growth
worms.
evidenced
those
local
origin
(
i.e.
segment
abutting
amputation
plan)
most
Our
results
favour
a
hybrid
flexible
model
relying
on
gradient
cell
along
antero-posterior
axis
animal.
Language: Английский
PDK-1/S6K and mTORC1 bypass systemic growth restrictions to promote regeneration
Ananthakrishnan Vijayakumar Maya,
No information about this author
Liyne Nogay,
No information about this author
Lara Heckmann
No information about this author
et al.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 6, 2024
Abstract
Tissue
damage
and
inflammation
trigger
systemic
signals
that
induce
catabolic
breakdown
nutrient
release
in
distant
organs,
a
process
well-characterized
the
context
of
tumor
cachexia.
While
mechanisms
allowing
tumors
to
circumvent
these
growth
restrictions
are
known,
physiological
processes
overcome
inflammation-induced
support
tissue
repair
regeneration
remain
largely
unexplored.
In
our
study,
we
use
model
developing
Drosophila
imaginal
discs
dissect
key
metabolic
signaling
adaptations
help
restrictions.
Our
findings
reveal
unique
strategy
used
by
rapidly
proliferating
cells
regenerating
domain.
Instead
relying
on
conventional
Insulin-PI3K-Akt
pathway,
utilize
JAK/STAT-PDK1-S6K
axis.
This
adaptation
facilitates
sustained
protein
synthesis
cellular
despite
catabolism
associated
with
low
insulin
signaling.
Specifically,
find
fat
body
is
driven
insulin-binding
factor
Impl2,
which
expressed
at
site
inflammatory
damage.
Notably,
regenerative
proliferation
also
supported
mTORC1
activity
upregulation
amino
acid
transporters
These
align
specific
metabolite
signature
hemolymph,
revealing
specialized
program
meets
demands
fast-proliferating
cells.
work
provides
insight
into
how
tissues
rewire
pathways
adapt
their
coordinate
conserved
provision
response.
have
important
implications
for
understanding
human
diseases
such
as
chronic
wounds
cancer.
Language: Английский
Coordination of cell cycle and morphogenesis during organ formation
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 21, 2023
Abstract
Organ
formation
requires
precise
regulation
of
cell
cycle
and
morphogenetic
events.
Using
the
Drosophila
embryonic
salivary
gland
(SG)
as
a
model,
we
uncover
role
SP1/KLF
transcription
factor
Huckebein
(Hkb)
in
coordinating
morphogenesis.
The
hkb
mutant
SG
exhibits
defects
invagination
positioning
organ
size
due
to
abnormal
death
cells.
Normal
development
involves
distal-to-proximal
progression
endoreplication
(endocycle),
whereas
cells
undergo
division,
leading
death.
Hkb
represses
expression
key
pro-apoptotic
genes
SG.
Knockdown
cyclin
E
or
cyclin-dependent
kinase
1,
overexpression
fizzy-related
rescues
most
observed
These
results
indicate
that
plays
critical
controlling
by
regulating
effectors
ensure
proper
formation.
Language: Английский