Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition DOI Creative Commons

Latifa Kazzazy,

Dávid Mező,

Kinga Nagy

et al.

Journal of Experimental Zoology Part B Molecular and Developmental Evolution, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

From the very moment of fertilization and throughout development, cells animal embryos have to continuously orchestrate dynamic reorganization their epigenetic landscapes. One earliest major events this occurs during time maternal-zygotic transition (MZT), when control developmental process gradually shifts from maternal factors (initially present within oocytes) genes embryo itself. As transcripts proteins are degraded, parental information is often erased, pioneer will turn on transcriptional activity zygotic genome. This activation also coincides with decompaction chromatin, which essential for successful initiation gene expression in zygote. Interestingly, past decades numerous studies reported findings that supported role noncanonical nucleotides MZT. These nucleobase moieties these covalently modified versions canonical bases, show a presence While most recent deciphered great detail methylcytosine its derivates, other Noncanonical bases received less attention. Here we suggest incorporation deoxyuridine-triphosphate (dUTP) or 6-methyl-deoxyadenine-triphosphate (6m-dATP) into genome not mere noise replication error but serves well-defined purpose: aid chromatin through timely induction DNA repair pathways.

Language: Английский

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition DOI Creative Commons

Latifa Kazzazy,

Dávid Mező,

Kinga Nagy

et al.

Journal of Experimental Zoology Part B Molecular and Developmental Evolution, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

From the very moment of fertilization and throughout development, cells animal embryos have to continuously orchestrate dynamic reorganization their epigenetic landscapes. One earliest major events this occurs during time maternal-zygotic transition (MZT), when control developmental process gradually shifts from maternal factors (initially present within oocytes) genes embryo itself. As transcripts proteins are degraded, parental information is often erased, pioneer will turn on transcriptional activity zygotic genome. This activation also coincides with decompaction chromatin, which essential for successful initiation gene expression in zygote. Interestingly, past decades numerous studies reported findings that supported role noncanonical nucleotides MZT. These nucleobase moieties these covalently modified versions canonical bases, show a presence While most recent deciphered great detail methylcytosine its derivates, other Noncanonical bases received less attention. Here we suggest incorporation deoxyuridine-triphosphate (dUTP) or 6-methyl-deoxyadenine-triphosphate (6m-dATP) into genome not mere noise replication error but serves well-defined purpose: aid chromatin through timely induction DNA repair pathways.

Language: Английский

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