Across two continents: the genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas DOI Creative Commons
Yocelyn T. Gutiérrez‐Guerrero, Megan Phifer‐Rixey, Michael W. Nachman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 2, 2023

A bstract Parallel clines across environmental gradients can be strong evidence of adaptation. House mice ( Mus musculus domesticus ) were introduced to the Americas by European colonizers and are now widely distributed from Tierra del Fuego Alaska. Multiple aspects climate, such as temperature, vary predictably latitude in Americas. Past studies North American populations latitudinal provided adaptation traits related body size, metabolism, behavior identified candidate genes using selection scans. Here, we investigate genomic signals on a second continent, South America, ask whether there is parallel multiple transects We first loci genome showing signatures climatic variation sampled transect accounting for neutral population structure. Consistent with previous results, most SNPs regulatory regions. Genes containing extreme outliers relate weight or immunity, fat, development function eye well associated cardiovascular renal systems. then combined these results published two America. While unique individual transects, found significant overlap among independently three providing identifying that likely underlie recent house Author summary Since their arrival colonizers, have successfully spread throughout There America adapted time, including evolution phenotypes (e.g., behavior) identification show selection. genetics find evolve identify links like function, bring together data continents determine if predictable, genetic changes response shared conditions. lies regions that, while many shared, core set all contribute These highlight value studying wild this model system.

Language: Английский

Female behavior drives the formation of distinct social structures in C57BL/6J versus wild-derived outbred mice in field enclosures DOI Creative Commons
Caleb C. Vogt, Matthew N. Zipple, Daniel D. Sprockett

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Background Social behavior and social organization have major influences on individual health fitness. Yet, biomedical research focuses studying a few genotypes under impoverished conditions. Understanding how lab conditions modified organizations of model organisms, such as mice, relative to natural populations is missing link between socioecology science. Results Using common garden design, we describe the formation structure in well-studied laboratory mouse strain, C57BL/6J, replicated mixed-sex over 10-day trials compared control with wild-derived outbred house mice outdoor field enclosures. We focus three key features systems: (i) territory establishment males, (ii) female relationships, (iii) networks formed by populations. Male territorial behaviors were similar but muted C57 mice. Female sharply differed from females, showing little bias toward cage mates exploring substantially more enclosures all other groups. consistently generated denser than Conclusions individually vary their spatial which scale shape overall organization. The repeatable societies highlights opportunities experimentally study interplay society biology using organisms.

Language: Английский

Citations

18
Unpacking the sepsis controversy DOI Creative Commons
John C. Alverdy

Trauma Surgery & Acute Care Open, Journal Year: 2025, Volume and Issue: 10(1), P. e001733 - e001733

Published: March 1, 2025

Despite its many definitions and revisions, consensus statements clinical guidelines, the term 'sepsis' continues to be referred as a discrete entity that is often claimed direct cause of mortality. The assertion sepsis can defined 'life-threatening organ dysfunction caused by dysregulated host response infection,' has led field dominated failed trials informed host-centered, pathogen-agnostic, animal experiments in which models do not recapitulate condition. observations from National Health Service England claim 77.5% deaths occur those aged 75 years or older USA indicating most patients dying have also been diagnosed with 'hospice qualifying conditions,' seem refute by, rather than associated with, 'dysregulated response.' This piece challenges current conceptual framework forms basis definition. Here we posit result both definition use inappropriate models, ineffective treatments continue pursued this field.

Language: Английский

Citations

1
Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice DOI Creative Commons
Jaroslav Piálek,

Ľudovít Ďureje,

Zuzana Hiadlovská

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

Language: Английский

Citations

0
Across two continents: The genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas DOI Creative Commons
Yocelyn T. Gutiérrez‐Guerrero, Megan Phifer‐Rixey, Michael W. Nachman

et al.

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(7), P. e1011036 - e1011036

Published: July 5, 2024

Replicated clines across environmental gradients can be strong evidence of adaptation. House mice ( Mus musculus domesticus ) were introduced to the Americas by European colonizers and are now widely distributed from Tierra del Fuego Alaska. Multiple aspects climate, such as temperature, vary predictably latitude in Americas. Past studies North American populations latitudinal provided adaptation traits related body size, metabolism, behavior identified candidate genes using selection scans. Here, we investigate genomic signals on a second continent, South America, ask whether there is parallel multiple transects We first loci genome showing signatures climatic variation sampled transect accounting for neutral population structure. Consistent with previous results, most SNPs putatively regulatory regions. Genes that contained extreme outliers relate weight or immunity, fat, eye function, cardiovascular system. then compared these results analyses published data two America. While unique individual transects, found significant overlap among independently three transects. These diverse, functions relating cardiac circadian rhythm, others. also shifts allele frequency gradients. Finally, combining all several associated weight. Overall, our provide shared responses identify likely underlie recent house

Language: Английский

Citations

2
Immunological roads diverged: mapping tuberculosis outcomes in mice DOI Creative Commons
Rachel Meade, Clare M. Smith

Trends in Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

The journey from phenotypic observation to causal genetic mechanism is a long and challenging road. For pathogens like Mycobacterium tuberculosis (Mtb), which causes (TB), host–pathogen coevolution has spanned millennia, costing millions of human lives. Mammalian models can systematically recapitulate host variation, producing spectrum disease outcomes. Leveraging genome sequences deep phenotyping data infected mouse reference populations (GRPs), quantitative trait locus (QTL) mapping approaches have successfully identified genomic regions associated with TB phenotypes. Here, we review the ongoing optimization QTL study design alongside advances in GRPs. These next-generation resources enabled identification novel interactions governing one most prevalent infectious diseases world today.

Language: Английский

Citations

2
Diverse wild-derived inbred strains provide a new community resource DOI
Michael W. Nachman, Beth L. Dumont

Mammalian Genome, Journal Year: 2024, Volume and Issue: 35(4), P. 551 - 555

Published: Aug. 19, 2024

Language: Английский

Citations

0
Working with Miraculous Mice: Mus musculus as a Model Organism DOI Creative Commons

Anick Standley,

Jinhan Xie, Angelica W.Y. Lau

et al.

Current Protocols, Journal Year: 2024, Volume and Issue: 4(10)

Published: Oct. 1, 2024

Abstract The laboratory mouse has been described as a “miracle” model organism, providing window by which we may gain an understanding of ourselves. Since the first recorded experiment in 1664, become most used animal biomedical research. Mice are ideally suited organism because their small size, short gestation period, large litter and genetic similarity to humans. This article provides broad overview is intended for undergraduates those new working with mice. We delve into history outline important terminology accurately describe research types mice available researchers reviewed, including outbred stocks, inbred strains, immunocompromised mice, genetically engineered critical role have played advancing knowledge areas oncology, immunology, pharmacology highlighted examining significant contribution Nobel Prize winning International mutagenesis programs accurate phenotyping models outlined. also explain considerations ethics; welfare principles replacement, refinement, reduction; choice experimental design. Finally, present practical advice maintaining colony, involves adequate training staff, logistics housing, monitoring colony health, breeding strategies. Useful resources listed. aim this equip reader appreciation enormous potential some complexities quest improve human health. © 2024 Author(s). Current Protocols published Wiley Periodicals LLC.

Language: Английский

Citations

0
Across two continents: the genomic basis of environmental adaptation in house mice (Mus musculus domesticus) from the Americas DOI Creative Commons
Yocelyn T. Gutiérrez‐Guerrero, Megan Phifer‐Rixey, Michael W. Nachman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 2, 2023

A bstract Parallel clines across environmental gradients can be strong evidence of adaptation. House mice ( Mus musculus domesticus ) were introduced to the Americas by European colonizers and are now widely distributed from Tierra del Fuego Alaska. Multiple aspects climate, such as temperature, vary predictably latitude in Americas. Past studies North American populations latitudinal provided adaptation traits related body size, metabolism, behavior identified candidate genes using selection scans. Here, we investigate genomic signals on a second continent, South America, ask whether there is parallel multiple transects We first loci genome showing signatures climatic variation sampled transect accounting for neutral population structure. Consistent with previous results, most SNPs regulatory regions. Genes containing extreme outliers relate weight or immunity, fat, development function eye well associated cardiovascular renal systems. then combined these results published two America. While unique individual transects, found significant overlap among independently three providing identifying that likely underlie recent house Author summary Since their arrival colonizers, have successfully spread throughout There America adapted time, including evolution phenotypes (e.g., behavior) identification show selection. genetics find evolve identify links like function, bring together data continents determine if predictable, genetic changes response shared conditions. lies regions that, while many shared, core set all contribute These highlight value studying wild this model system.

Language: Английский

Citations

1