Progesterone Aids in Alleviation of Nicotine Withdrawal Symptoms: A Systematic Review DOI Open Access

Hijab Zafar,

Maria Binte Sarfraz,

Muhammad Mazhar

et al.

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(12)

Published: Jan. 1, 2022

Background: A systematic review of studies on progesterone’s usage in the cure nicotine craving was undertaken. Progesterone is a steroid hormone that influences reproductive system as well -Aminobutyric acid type (GABAA) receptors, glycine, kainite, and nicotinic receptors. It thought progesterone might help with withdrawal symptoms addicted people. Method: Two authors completed literature search independently using Boolean approach searching key terms (i.e. AND treat*, drug addiction withdrawal, smok*, nicotine), screened title, abstract full-text for data extraction during June 2021. PubMed, NIH, Elsevier, Scopus, Web Science, Google Scholar, Science Direct databases performed. The included seven (7) articles out seventy-eight (78) downloaded met inclusion criteria. Microsoft Excel IBM SPSS were used statistical analysis. Results: These 147 males 377 females, which 46 pregnant. average age ranged between 18 45 years. participants those who had smoked 10-25 cigarettes/day year. carbon monoxide measuring over 10ppm signifies recent smoking found 10% (n=12) given 400mg progesterone, 11% (n=14) 200 mg 13% (n=16) placebo groups. prescription 400 mg/day effective decreasing cravings to smoke, while dose helped improving cognitive performance. Females group exhibited significantly lower scores than females group. significant difference has been observed 7-day PPA at week 4 among women i.e. “PRO: (35.3%) vs. PBO: 9 (17.3%), Odds Ratio: 2.61 (95% confidence interval) p=0.041”, but not men 13 (23.2%) 12 (21.1%), 1.13 (0.47, 2.76) p=0.782”. There some evidence PRO delayed relapse (Days Relapse; PRO: 20.5 ±29.6 14.3 ±26.8, p=0.03) (PRO: 13.4 ±25.9 13.3 ± 23.8, p=0.69). Nearly half smoke before pregnancy can quit pregnancy. However, 40-52% reverts within 2 weeks 70-80% resumes year childbirth. Conclusion: In majority instances, 200mg administered, favorable outcomes obtained. Although there no major side effects observed, few moderate such breast tenderness reported individuals. As result, therapy helps alleviate symptoms, lowers intensity, treats both women. Keywords: prescription, treatment, addiction, smoking,

Language: Английский

Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study (Preprint) DOI
J. O. Schwab, Jonas Wachinger, Richard Munana

et al.

Published: March 1, 2023

BACKGROUND Uncontrolled hypertension is a leading risk factor for cardiovascular diseases. In Uganda, such diseases account approximately 10% of all deaths, with 1 in 5 adults having (>90% the hypertensive cases are uncontrolled). Although basic health care country available free cost at government facilities, regularly accessing medication to control difficult because supply chain challenges impede availability. Clients therefore frequently suspend treatment or buy individually private facilities pharmacies (incurring significant costs). recent years, mobile (mHealth) interventions have shown increasing potential addressing system sub-Saharan Africa, but acceptability, feasibility, and uptake conditions money approaches chronic disease management remain understudied. OBJECTIVE This study aims design pilot-test money–based intervention increase availability antihypertensive lower clients’ out-of-pocket payments. We will build on existing local assess designed intervention. Furthermore, rather than entering setting ready-made intervention, this research place emphasis gathering applied ethnographic insights early, which can then inform parameters prototype concurrent trial. METHODS conduct mixed methods following human-centered approach. begin by conducting extensive qualitative range stakeholders (clients; providers; religious, cultural, community leaders; academics; policy makers district national levels) their perceptions management, money-saving systems, context care. Our results design, iterative adaptation, implementation an mHealth-facilitated pooled financing prototype. At conclusion, finalized be evaluated quantitatively via randomized controlled RESULTS As August 2023, data collection, started November 2022, ongoing, analysis first interviews underway platform design. Recruitment quantitative part began 2023. CONCLUSIONS aim ongoing discourse novel sustainable pathways facilitate access resource-constrained settings. CLINICALTRIAL German registry clinical trials DRKS00030922; https://drks.de/search/en/trial/DRKS00030922 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/46614

Language: Английский

Citations

0

Awareness of Degenerative Cervical Myelopathy Among Medical Students in Aseer region, Saudi Arabia DOI Open Access

Shehata Farag Shehata,

Saeed Ali Alqarni,

Saud Muhammed Ayyashi

et al.

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(12)

Published: Jan. 1, 2022

Background: Cervical myelopathy is the most common cause of acquired spinal cord compromise. The concept degenerative cervical (DCM), defined as symptomatic associated with arthropathic changes in spine axis, being introduced. Patients DCM visit many doctors due to a variety symptoms, mainly orthopedics, neurosurgeons, neurologists, or physiotherapists. Aim: This study aims assess awareness and perception Degenerative Myelopathy among medical students Aseer region, Saudi Arabia. Methods: A descriptive cross-sectional survey was conducted Southern Arabia targeting all interns at College Medicine. An online questionnaire initiated by researchers after intensive literature review expert’s consultation. final published using social media platforms from 1st September 3rd September, 2022. uploaded their friends, relatives till no more new answers were obtained. Results: total 380 completed survey. Students’ ages ranged 18 30 years mean age 22.6 ± 2.1 old. Exactly 235 (61.8%) females 212 (55.8%) clinical years. 106 (27.9%) had good level regarding while 274 (72.1%) poor level. reported source information internet (46.3%), followed lectures (33.9%), (30%), textbook (18.9%), workshop (15.5%). Conclusion: In conclusion, current showed that students’ especially male others who not been taught about disease. Also, prominent rather than lectures. Keywords: myopathy, myopathy disorders, students, Awareness,

Language: Английский

Citations

0

Knowledge and phobias about the use of topical corticosteroids among the Saudi population: A cross-sectional study DOI Open Access
Manar A Alotaibi,

Haifa A. Alotaibi,

Khalid A. Bin Abdulrahman

et al.

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(12)

Published: Jan. 1, 2022

Background: Topical corticosteroids are the first line of treatment for many dermatological disorders. Patients frequently have excessive concerns about side effects steroids and may even refuse to use topical treat their conditions due fear steroids. This study aimed explore knowledge phobias regarding using among Saudi population. Method: A cross-sectional was conducted examine public fears in 2022. previously developed questionnaire adapted used this study. Binary logistic regression identify factors that affect participants’ corticosteroids. Results: total 1,889 people participated Around half participants (46.2%) reported The vast majority (88.8%) effectively managed condition. Approximately (47.1%) worrying when About 15.0% having delayed a hospital visit concern prescribing Although 16.4% them refused get prescribed corticosteroids, 17.0% not applied showed low level phobia with mean score 1.7 (SD: 1.6), representing 28.3% (out maximum score). statistically significant difference between who experienced or presently experiencing skin disease (p <0.05). Conclusion: Phobia is common problem warrants further investigation. It affects patients’ compliance corticosteroid therapy, which ultimately will result worsening clinical outcomes. Healthcare professionals should focus on education correct any misconceptions group medications. Keywords: corticosteroids; Fear; Phobia; Skin diseases; Arabia

Language: Английский

Citations

0

Can Probiotics be used as an adjuvant thereby for diabetes - hope or hype? Narrative review of the literature DOI Open Access

Mohammed Alfawaz,

Wafi Almutawa,

Fawaz Abdullah M Alfawaz

et al.

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(12)

Published: Jan. 1, 2022

Diabetes is a metabolic disorder that characterized by inadequate insulin secretion the pancreas or lack in ability of existing to function properly. So, diabetes forms fertile media for many diseases and embodies risk human-being’s health. Unfortunately, incidence increasing every year. Over decades, several strategies have been tried specialists control diabetes, some which are medical herbal. Although mellitus represents growing global epidemic disease, at moment there no absolute solution molecular level targets disease. Despite fact bacterial functions, such as gut barrier stability butyrate production, crucial preserving normal blood sugar levels, body evidence suggests naturally occurring bacteria underrepresented intestinal tracts people with type 2 (T2D){Sharma, 2019 #8}. In fact, we need look possibility using probiotics outpatient clinic. Probiotics demonstrated be helpful patients mellitus, particularly cellular level, based on clinical trials animal research, well their high tolerability. preclinical investigations human trials{Kocsis, 2020 #7}, shown they can lower fasting glucose levels diabetes. Recently, used treat range ailments, autoimmune conditions, allergic reactions, andinflammation. However, was lot heterogeneity these trials. Examples include kind species used, how effectiveness. our review, focused reviewing role an adjuvant therapy lowering troubled metabolism sugar. Keywords: probiotics; diabetes; DM; inflammation; therapy.

Language: Английский

Citations

0

Progesterone Aids in Alleviation of Nicotine Withdrawal Symptoms: A Systematic Review DOI Open Access

Hijab Zafar,

Maria Binte Sarfraz,

Muhammad Mazhar

et al.

World Family Medicine Journal/Middle East Journal of Family Medicine, Journal Year: 2022, Volume and Issue: 20(12)

Published: Jan. 1, 2022

Background: A systematic review of studies on progesterone’s usage in the cure nicotine craving was undertaken. Progesterone is a steroid hormone that influences reproductive system as well -Aminobutyric acid type (GABAA) receptors, glycine, kainite, and nicotinic receptors. It thought progesterone might help with withdrawal symptoms addicted people. Method: Two authors completed literature search independently using Boolean approach searching key terms (i.e. AND treat*, drug addiction withdrawal, smok*, nicotine), screened title, abstract full-text for data extraction during June 2021. PubMed, NIH, Elsevier, Scopus, Web Science, Google Scholar, Science Direct databases performed. The included seven (7) articles out seventy-eight (78) downloaded met inclusion criteria. Microsoft Excel IBM SPSS were used statistical analysis. Results: These 147 males 377 females, which 46 pregnant. average age ranged between 18 45 years. participants those who had smoked 10-25 cigarettes/day year. carbon monoxide measuring over 10ppm signifies recent smoking found 10% (n=12) given 400mg progesterone, 11% (n=14) 200 mg 13% (n=16) placebo groups. prescription 400 mg/day effective decreasing cravings to smoke, while dose helped improving cognitive performance. Females group exhibited significantly lower scores than females group. significant difference has been observed 7-day PPA at week 4 among women i.e. “PRO: (35.3%) vs. PBO: 9 (17.3%), Odds Ratio: 2.61 (95% confidence interval) p=0.041”, but not men 13 (23.2%) 12 (21.1%), 1.13 (0.47, 2.76) p=0.782”. There some evidence PRO delayed relapse (Days Relapse; PRO: 20.5 ±29.6 14.3 ±26.8, p=0.03) (PRO: 13.4 ±25.9 13.3 ± 23.8, p=0.69). Nearly half smoke before pregnancy can quit pregnancy. However, 40-52% reverts within 2 weeks 70-80% resumes year childbirth. Conclusion: In majority instances, 200mg administered, favorable outcomes obtained. Although there no major side effects observed, few moderate such breast tenderness reported individuals. As result, therapy helps alleviate symptoms, lowers intensity, treats both women. Keywords: prescription, treatment, addiction, smoking,

Language: Английский

Citations

0